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1.发明授权
公开(公告)号：US5705103A
公开(公告)日：1998-01-06
申请号：US755131
申请日：1996-11-22
CPC分类号： C09K11/07
摘要： A chemiluminescent composition comprising an oxalate component comprising polystyrene or homopoly-.alpha.-methylstyrene containing an oxalate ester; an activator component comprising a solution of a peroxide compound and a catalyst in a first solvent; and a fluorescer contained in the oxalate component, activator component, or in both the oxalate component and the activator component. The first solvent is preferably a propylene glycol dialkyl ether. The chemiluminescent composition, when activated, permits light to be produced of controllable duration.
摘要翻译： 包含草酸盐组分的化学发光组合物，其包含聚苯乙烯或含有草酸酯的均聚-α-甲基苯乙烯; 活化剂组分，其包含在第一溶剂中的过氧化物化合物和催化剂的溶液; 和包含在草酸盐组分，活化剂组分中，或在草酸盐组分和活化剂组分中的荧光剂。 第一溶剂优选为丙二醇二烷基醚。 化学发光组合物在被激活时允许产生可控持续时间的光。
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公开(公告)号：US5597517A
公开(公告)日：1997-01-28
申请号：US640069
申请日：1996-04-30
CPC分类号： C09K11/07
摘要： A chemiluminescent composition comprising an oxalate component comprising an oxalate ester and a solvent, an activator component comprising a peroxide compound and a catalyst and a fluorescer contained in the oxalate component and/or the activator component. The solvent contained in the oxalate component comprises a propylene glycol dihydrocarbyl ether containing one to three propylene moieties and each hydrocarbyl moiety contains up to 8 carbon atoms and is independently selected from the group consisting of straight chain alkyl, branched chain alkyl, cycloalkyl, aryl, alkaryl and aralkyl groups.
摘要翻译： 一种化学发光组合物，其包含草酸酯组分和溶剂的草酸盐组分，包含过氧化物化合物的活化剂组分和包含在草酸盐组分和/或活化剂组分中的催化剂和荧光剂。 草酸酯组分中所含的溶剂包含含有一至三个丙烯部分的丙二醇二烃基醚，每个烃基部分含有至多8个碳原子，独立地选自直链烷基，支链烷基，环烷基，芳基， 烷芳基和芳烷基。
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公开(公告)号：US5663415A
公开(公告)日：1997-09-02
申请号：US671604
申请日：1996-06-28
IPC分类号： C07C209/82 , C07C69/88
CPC分类号： C07C209/82
摘要： A process for preparing pure antihistamine tannate compositions. The antihistamine in the form of its free base is contacted with tannic acid in the presence of water for a period of time of about 5 minutes to 4 hours and at a maximum temperature such that not more than about 5 wt. % of the antihistamine tannate will be decomposed. Water is removed from the antihistamine tannate by freeze-drying.
摘要翻译： 制备纯的抗组胺药单宁组合物的方法。 其游离碱形式的抗组胺剂在水存在下与丹宁酸接触约5分钟至4小时，最高温度不超过约5重量％。 抗组氨酸丹宁酸的百分比将分解。 通过冷冻干燥将抗氧化剂组合物去除水。
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公开(公告)号：US5599846A
公开(公告)日：1997-02-04
申请号：US671160
申请日：1996-06-28
IPC分类号： A61K31/137 , A61K31/135
CPC分类号： A61K31/137
摘要： Phenylephrine tannate compositions are disclosed wherein the phenylephrine tannate has a minimum purity level of at least 95%. The composition also contains a minor amount of water, but no significant quantities of organic compounds or solvents other than water are present. The phenylephrine tannate will have a density of at least 0.6 g/cc.
摘要翻译： 公开了其中苯肾上腺素丹宁酸具有至少95％的最低纯度水平的鞣酸去氧肾上腺素组合物。 该组合物还含有少量的水，但不存在显着量的除水以外的有机化合物或溶剂。 丹宁苯肾上腺素的密度至少为0.6g / cc。
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5.发明授权Glucosamine sulfate calcium chloride composition and processes for the preparation of glucosamine sulfate metal chlorides 失效硫酸氨基葡萄糖氯化钙组合物及硫酸氨基葡萄糖金属氯化物的制备方法公开(公告)号：US06472380B1
公开(公告)日：2002-10-29
申请号：US09708197
申请日：2000-11-08
IPC分类号： A61K3170
摘要： Glucosamine compositions comprising the compounds glucosamine sulfate metal chloride, wherein the metal, i.e., the cation is potassium, sodium, magnesium, lithium, calcium, zinc or manganese. The compounds have purity levels of at least about 97%, with water present in a maximum amount of about 10 wt. %, based on the weight of the composition. The compounds are prepared by contacting glucosamine hydrochloride with a hydroxide of the metal in the presence of water to form a first aqueous solution of the free glucosamine base and a chloride of the metal, acidifying the first aqueous solution with sulfuric acid to form a second aqueous solution of glucosamine sulfate and the chloride of the metal, and thereafter freeze-drying the second aqueous solution at a temperature and at a reduced pressure for such period of time that at least about 90 wt. % of the water is removed and decomposition of the compound glucosamine sulfate metal chloride is limited to a maximum of about 3%.
摘要翻译： 包含化合物硫酸葡萄糖胺金属氯化物的葡糖胺组合物，其中金属即阳离子是钾，钠，镁，锂，钙，锌或锰。 化合物的纯度至少为约97％，水的存在量最大为约10wt。 ％，基于组合物的重量。 所述化合物是通过在水存在下使葡萄糖胺盐酸盐与金属的氢氧化物接触而形成游离葡糖胺碱和金属氯化物的第一水溶液，用硫酸酸化第一水溶液以形成第二水溶液 硫酸葡糖胺溶液和金属氯化物，然后在温度和减压下将第二水溶液冷冻干燥此时间至少约90wt。 除去水的百分比，并且化合物硫酸葡萄糖胺金属氯化物的分解被限制在最多约3％。
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公开(公告)号：US07001886B2
公开(公告)日：2006-02-21
申请号：US10826538
申请日：2004-04-16
CPC分类号： A61K45/06 , A61K31/137 , A61K31/44 , A61K31/7024 , A61K2300/00
摘要： The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydramine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.
摘要翻译： 本发明涉及通过在约75至约150℃的温度下将苯海拉明游离碱与纯鞣酸或作为含有至多约20重量％的鞣酸的含水浆液反应来制备苯海拉明酸鞣酸盐的方法。 ％ 水。 苯海拉明游离碱可以通过使市售的苯海拉明盐如马来酸苯海拉明与碱如氢氧化钠水溶液反应而获得。 所得的苯海拉明酸鞣酸盐具有延长的释放性能，并且可用作药物组合物作为人类的抗组胺剂。
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公开(公告)号：US06677381B1
公开(公告)日：2004-01-13
申请号：US10017131
申请日：2001-12-14
IPC分类号： A61K31135
CPC分类号： A61K45/06 , A61K31/137 , A61K31/44 , A61K31/7024 , Y10S514/849 , A61K2300/00
摘要： The invention pertains to a novel composition comprising guaifenesin tannate and to a method for preparing guaifenesin tannate by reacting guaifenesin with tannic acid at a temperature above the melting point of guaifenesin. The guaifenesin tannate has extended release properties and is useful in pharmaceutical compositions as an expectorant in warm-blooded animals or as a muscle relaxant in non-human animals.
摘要翻译： 本发明涉及包含愈创甘油单宁酸盐的新型组合物，以及通过在愈创甘油醚的熔点以上的温度下使愈创甘油与鞣酸反应来制备萱草gu if烯的方法。 愈创甘油单宁具有延长的释放性能，并且可用于作为温血动物中的祛痰剂的药物组合物或作为非人动物中的肌肉松弛剂。
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8.发明授权Glucosamine sulfate metal chloride compositions and process of preparing same 有权硫酸氨基葡萄糖金属氯化物组合物及其制备方法
公开(公告)号：US5902801A
公开(公告)日：1999-05-11
申请号：US191169
申请日：1998-11-13
摘要： Glucosamine compositions comprising the compounds glucosamine sulfate metal chloride, wherein the metal, i.e. the cation, is lithium, sodium, magnesium, zinc or manganese. The compounds have purity levels of at least about 97%, with water present in a maximum amount of about 10 wt. %, based on the weight of the composition. The compounds are prepared by contacting glucosamine hydrochloride with the metal sulfate in the presence of water to form an aqueous solution of glucosamine sulfate metal chloride and thereafter freeze-drying the solution at a temperature and at a reduced pressure for such period of time that at least about 90 wt. % of the water is removed and decomposition of the compound glucosamine sulfate metal chloride is limited to a maximum of about 3%.
摘要翻译： 包含化合物硫酸葡萄糖胺金属氯化物的葡糖胺组合物，其中金属即阳离子是锂，钠，镁，锌或锰。 化合物的纯度至少为约97％，水的存在量最大为约10wt。 ％，基于组合物的重量。 该化合物通过在水存在下使葡萄糖胺盐酸盐与金属硫酸盐接触以制备硫酸氨基葡萄糖金属氯化物的水溶液，然后在温度和减压下将溶液冷冻干燥此时间至少 约90重量％ 除去水的百分比，并且化合物硫酸葡萄糖胺金属氯化物的分解被限制在最多约3％。
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9.发明授权
公开(公告)号：US5843923A
公开(公告)日：1998-12-01
申请号：US83173
申请日：1998-05-22
摘要： A composition comprising the compound glucosamine sulfate potassium chloride having a purity level of at least about 97% and water present in a maximum amount of about 10 wt. %, based on the weight of the composition. The compound is prepared by contacting glucosamine hydrochloride with potassium sulfate in the presence of water to form an aqueous solution of glucosamine sulfate potassium chloride and thereafter freeze-drying the solution at a temperature and at a reduced pressure for such period of time that at least about 90 wt. % of the water is removed and decomposition of the compound glucosamine sulfate potassium chloride is limited to a maximum of about 3%.
摘要翻译： 包含纯度水平至少约97％的化合物硫酸葡萄糖胺氯化钾和最大量为约10重量％的水的组合物。 ％，基于组合物的重量。 该化合物通过在水存在下使葡萄糖胺盐酸盐与硫酸钾接触来制备，以形成硫酸氨基葡萄糖氯化钾的水溶液，然后在温度和减压下将溶液冷冻干燥此时间至少约 90重量％ 除去水的百分比，化合物硫酸氨基葡萄糖氯化钾的分解被限制在最多约3％。
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10.发明授权Process for restoration of chemical lighting potential of a chemiluminescent lighting system 失效化学发光照明系统的化学照明电位恢复过程
公开(公告)号：US5294377A
公开(公告)日：1994-03-15
申请号：US9892
申请日：1993-01-27
CPC分类号： C09K11/07
摘要： A process for the restoration of the initial chemical lighting potential of the oxalate component of a chemiluminescent lighting system. The oxalate component comprises an oxalate diester in a first liquid solution which prior to restoration exhibits a failure to produce initial high intensity luminosity upon mixture of the oxalate component with a liquid activator component comprising a peroxide in a second liquid solution. The process comprises contacting the oxalate component with magnesium silicate or calcium silicate for a period of time sufficient to correct the failure and thereafter separating the oxalate component from the selected silicate.
摘要翻译： 一种用于恢复化学发光照明系统的草酸盐组分的初始化学照明电位的方法。 草酸盐组分包含在第一液体溶液中的草酸二酯，在恢复之前，当将草酸盐组分与包含第二液体溶液中的过氧化物的液体活化剂组分混合时，其不能产生初始高强度发光度。 该方法包括使草酸酯组分与硅酸镁或硅酸钙接触足够长的时间来校正失效，然后从所选择的硅酸盐中分离出草酸盐组分。
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