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1.发明授权N-terminal site selective inhibitors of human angiotensin conversion enzyme (ACE) 失效人血管紧张素转换酶（ACE）的N-末端位点选择性抑制剂公开(公告)号：US06482797B1
公开(公告)日：2002-11-19
申请号：US09719573
申请日：2001-01-30
申请人： Vincent Dive , Joël Cotton , Philippe Cuniasse , Athanasios Yiotakis , Pierre Corvol , Annie Michaud , Marie-Thérèse Chauvet , Joël Menard , Eric Ezan
发明人： Vincent Dive , Joël Cotton , Philippe Cuniasse , Athanasios Yiotakis , Pierre Corvol , Annie Michaud , Marie-Thérèse Chauvet , Joël Menard , Eric Ezan
IPC分类号： A61K3800
摘要： The invention relates to peptide derivatives that can be used as selective inhibitors of the N-terminal site of human angiotensin-converting enzyme. The derivatives comprise the amino acid sequence with the following formula: -Asp-Phe-&PSgr;(PO2CH2)-Ala-Xaa′- (I) wherein: &PSgr;(PO2CH2) indicates that the peptide bond (CONH) between Phe and Ala has been replaced by the phosphonic bond PO2CH2, and Xaa′ represents an amino acid residue. They can be used in pharmaceutical formulations, particularly to protect haematopoietic strain cells of patients undergoing aggressive chemotherapy or radiotherapy treatment.
摘要翻译： 本发明涉及可用作人血管紧张素转换酶的N-末端位点的选择性抑制剂的肽衍生物。该衍生物包含具有下式的氨基酸序列：其中：＆amp; PSgr;（PO2CH2）表示肽键 Phe和Ala之间的（CONH）已被膦酸键PO2CH2代替，Xaa'代表氨基酸残基。它们可用于药物制剂，特别是用于保护接受侵袭性化疗或放疗治疗的患者的造血细胞株。
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2.发明授权Phosphinic pseudo-peptides that may be used as matrix zinc metalloprotease inhibitors 失效可用作基质锌金属蛋白酶抑制剂的磷化假性肽公开(公告)号：US06630501B1
公开(公告)日：2003-10-07
申请号：US09869303
申请日：2002-03-25
申请人： Vincent Dive , Philippe Cuniasse , Marie-Christine Rio , Paul Basset , Athanasios Yotakis , Fabrice Beau , Stamania Vassiliou
发明人： Vincent Dive , Philippe Cuniasse , Marie-Christine Rio , Paul Basset , Athanasios Yotakis , Fabrice Beau , Stamania Vassiliou
IPC分类号： A61K31404
CPC分类号： C07F9/65586 , C07F9/301 , C07F9/5728 , C07F9/65583
摘要： The invention relates to pseudo-peptides according to the formula: wherein R1 is a group inhibiting an amine function, or an amino acid residue or peptide with an inhibited terminal amino function, R2 represents the lateral chain of a natural or non-natural amino acid, R3 represents: 1) the lateral chain of a natural amino acid except for Gly and Ala, not substituted or substituted by an aryl group, 2) an aralkyl group, or 3) an alkyl group comprising at least 3 carbon atoms, and R4 represents a lateral chain of natural or non-natural amino acid. They are useful as matrix zinc metalloprotease inhibitors, particularly in the treatment of cancer.
摘要翻译： 本发明涉及根据下式的假肽：其中R 1是抑制胺官能团的基团，或具有抑制的末端氨基官能团的氨基酸残基或肽，R 2表示天然或侧链的侧链 非天然氨基酸，R 3表示：1）除未被芳基取代或取代的Gly和Ala之外的天然氨基酸的侧链，2）芳烷基，或3）包含 至少3个碳原子，而R 4表示天然或非天然氨基酸的侧链。它们可用作基质锌金属蛋白酶抑制剂，特别是用于治疗癌症。
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3.发明授权Cysteine-free efficient Technetium (Tc) or Rhenium (Re) chelating peptide tags and their use 有权不含半胱氨酸的有效锝（Tc）或铼（Re）螯合肽标签及其用途公开(公告)号：US09234001B2
公开(公告)日：2016-01-12
申请号：US13133446
申请日：2009-12-28
申请人： Loïc Le Clainche , Alain Lecoq , Sophie Zinn-Justin , Robert Thai , Michel Masella , Philippe Cuniasse
发明人： Loïc Le Clainche , Alain Lecoq , Sophie Zinn-Justin , Robert Thai , Michel Masella , Philippe Cuniasse
CPC分类号： C07K5/0806 , C07K5/06026 , C07K5/081 , C07K5/0815 , C07K5/1013 , C07K7/06 , C07K7/08
摘要： The present invention relates to a peptide tag which can be used to bind a Technetium (Tc) or Rhenium (Re) radionuclide to a protein of interest which comprises the peptide tag and allows the imaging of such a tagged protein. In particular the present invention relates to a peptide tag which chelates a Tc or Re atom but which does not comprise a Cysteine residue.
摘要翻译： 本发明涉及一种肽标签，其可用于将锝（Tc）或铼（Re）放射性核素与目的蛋白质结合，其包含肽标签并允许这种标记蛋白质的成像。 特别地，本发明涉及螯合Tc或Re原子但不包含半胱氨酸残基的肽标签。
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4.发明申请Cysteine-Free Efficient Technetium (Tc) or Rhenium (Re) Chelating Peptide Tags and Their Use 有权无半胱氨酸高效锝（Tc）或铼（Re）螯合肽标签及其用途公开(公告)号：US20110318827A1
公开(公告)日：2011-12-29
申请号：US13133446
申请日：2009-12-28
申请人： Loïc Le Clainche , Alain Lecoq , Sophie Zinn-Justin , Robert Thai , Michel Masella , Philippe Cuniasse
发明人： Loïc Le Clainche , Alain Lecoq , Sophie Zinn-Justin , Robert Thai , Michel Masella , Philippe Cuniasse
CPC分类号： C07K5/0806 , C07K5/06026 , C07K5/081 , C07K5/0815 , C07K5/1013 , C07K7/06 , C07K7/08
摘要： The present invention relates to a peptide tag which can be used to bind a Technetium (Tc) or Rhenium (Re) radionuclide to a protein of interest which comprises the peptide tag and allows the imaging of such a tagged protein. In particular the present invention relates to a peptide tag which chelates a Tc or Re atom but which does not comprise a Cysteine residue.
摘要翻译： 本发明涉及一种肽标签，其可用于将锝（Tc）或铼（Re）放射性核素与目的蛋白质结合，其包含肽标签并允许这种标记蛋白质的成像。 特别地，本发明涉及螯合Tc或Re原子但不包含半胱氨酸残基的肽标签。
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