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公开(公告)号:US20120258180A1
公开(公告)日:2012-10-11
申请号:US13442294
申请日:2012-04-09
申请人: Vincent Louis Giranda , Alexander R. Shoemaker , Kaitlin E. Browman , Shailen K. Joshi , Jill-desiree Brederson , Thomas D. Penning
发明人: Vincent Louis Giranda , Alexander R. Shoemaker , Kaitlin E. Browman , Shailen K. Joshi , Jill-desiree Brederson , Thomas D. Penning
IPC分类号: A61K31/4184 , A61K33/24 , A61P25/02 , A61K31/437
CPC分类号: C07D403/04 , A61K31/337 , A61K31/4184 , A61K31/475 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要: The present invention relates to the method of treating chemotherapy-induced neuropathy in a subject in need thereof with the use of a poly(ADP-ribose)polymerase (PARP) inhibitor.
摘要翻译: 本发明涉及使用聚(ADP-核糖)聚合酶(PARP)抑制剂治疗有需要的受试者的化疗诱发的神经病变的方法。
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公开(公告)号:US20100210682A1
公开(公告)日:2010-08-19
申请号:US12709125
申请日:2010-02-19
申请人: Connie R. Faltynek , Arthur R. Gomtsyan , Marie P. Honore , Michael F. Jarvis , Shailen K. Joshi , Michael E. Kort , Philip R. Kym , Torben R. Neelands , Regina M. Reilly , Carol S. Surowy
发明人: Connie R. Faltynek , Arthur R. Gomtsyan , Marie P. Honore , Michael F. Jarvis , Shailen K. Joshi , Michael E. Kort , Philip R. Kym , Torben R. Neelands , Regina M. Reilly , Carol S. Surowy
IPC分类号: A61K31/4725 , A61K31/416 , A61K31/444 , A61K31/421 , A61P29/00
CPC分类号: A61K31/416 , A61K31/421 , A61K31/444 , A61K31/4725
摘要: Disclosed herein are methods for increasing analgesic potency of TRPV1 antagonists, said methods comprise of repeated administration of the TRPV1 antagonists in a subject. Methods for treating or preventing pain by repeated administration of a TRPV1 antagonist are also discussed.
摘要翻译: 本文公开了增加TRPV1拮抗剂的止痛效力的方法,所述方法包括在受试者中重复施用TRPV1拮抗剂。 还讨论了通过重复施用TRPV1拮抗剂治疗或预防疼痛的方法。
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