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公开(公告)号：US08450320B2
公开(公告)日：2013-05-28
申请号：US13086556
申请日：2011-04-14
Applicant: Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
Inventor： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
IPC: A61K31/4985
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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![PYRIDAZINO[4,5-D]PYRIMIDIN-5(6H)-ONE INHIBITORS OF KINASES](/abs-image/US/2013/01/24/US20130023523A1/abs.jpg.150x150.jpg)
公开(公告)号：US20130023523A1
公开(公告)日：2013-01-24
申请号：US13552876
申请日：2012-07-19
Applicant: Gui-Dong Zhu , Jane Gong , Andrew S. Judd , Virajkumar B. Ghandi , Alexander R. Shoemaker , Thomas D. Penning , Michael R. Michaelides , Chunqiu Lai , Keith W. Woods
Inventor： Gui-Dong Zhu , Jane Gong , Andrew S. Judd , Virajkumar B. Ghandi , Alexander R. Shoemaker , Thomas D. Penning , Michael R. Michaelides , Chunqiu Lai , Keith W. Woods
IPC: C07D487/04 , A61K31/551 , A61K31/5377 , A61K31/5025 , A61P35/00
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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![Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases](/abs-image/US/2014/08/05/US08796289B2/abs.jpg.150x150.jpg)
公开(公告)号：US08796289B2
公开(公告)日：2014-08-05
申请号：US13552876
申请日：2012-07-19
Applicant: Gui-Dong Zhu , Jane Gong , Andrew S. Judd , Virajkumar B. Ghandi , Alexander R. Shoemaker , Thomas D. Penning , Michael R. Michaelides , Chunqui Lai , Keith W. Woods
Inventor： Gui-Dong Zhu , Jane Gong , Andrew S. Judd , Virajkumar B. Ghandi , Alexander R. Shoemaker , Thomas D. Penning , Michael R. Michaelides , Chunqui Lai , Keith W. Woods
IPC: A01N43/90 , A61K31/519 , C07D487/00
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein B, R1, R2, R4, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中B，R 1，R 2，R 4和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如wee-1的激酶和治疗诸如癌症的疾病的方法。
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Patent Agency Ranking
公开(公告)号：US20120258180A1
公开(公告)日：2012-10-11
申请号：US13442294
申请日：2012-04-09
Applicant: Vincent Louis Giranda , Alexander R. Shoemaker , Kaitlin E. Browman , Shailen K. Joshi , Jill-desiree Brederson , Thomas D. Penning
Inventor： Vincent Louis Giranda , Alexander R. Shoemaker , Kaitlin E. Browman , Shailen K. Joshi , Jill-desiree Brederson , Thomas D. Penning
IPC: A61K31/4184 , A61K33/24 , A61P25/02 , A61K31/437
CPC classification number: C07D403/04 , A61K31/337 , A61K31/4184 , A61K31/475 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to the method of treating chemotherapy-induced neuropathy in a subject in need thereof with the use of a poly(ADP-ribose)polymerase (PARP) inhibitor.
Abstract translation: 本发明涉及使用聚（ADP-核糖）聚合酶（PARP）抑制剂治疗有需要的受试者的化疗诱发的神经病变的方法。
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公开(公告)号：US20110257187A1
公开(公告)日：2011-10-20
申请号：US13086580
申请日：2011-04-14
Applicant: Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
Inventor： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
IPC: A61K31/502 , C07D401/02 , A61P35/00 , C07D401/14
CPC classification number: C07D471/04 , C07D401/04
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US08614318B2
公开(公告)日：2013-12-24
申请号：US11491851
申请日：2006-07-24
Applicant: Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander R. Shoemaker , Michael J. Mitten
Inventor： Milan Bruncko , Hong Ding , Steven Elmore , Aaron Kunzer , Christopher L. Lynch , William McClellan , Cheol-Min Park , Andrew Petros , Xiaohong Song , Xilu Wang , Noah Tu , Michael Wendt , Alexander R. Shoemaker , Michael J. Mitten
IPC: C07D211/06 , C07D413/02
CPC classification number: C07D233/06 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/20 , C07D207/24 , C07D207/50 , C07D211/14 , C07D211/20 , C07D211/26 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/72 , C07D213/36 , C07D213/38 , C07D213/42 , C07D213/70 , C07D213/74 , C07D213/81 , C07D213/82 , C07D215/12 , C07D231/12 , C07D231/56 , C07D233/61 , C07D233/64 , C07D235/08 , C07D239/06 , C07D239/38 , C07D241/04 , C07D249/18 , C07D257/04 , C07D261/20 , C07D263/12 , C07D263/22 , C07D263/58 , C07D265/30 , C07D267/10 , C07D273/01 , C07D277/36 , C07D277/74 , C07D295/155 , C07D295/185 , C07D295/30 , C07D307/14 , C07D307/22 , C07D307/81 , C07D309/14 , C07D309/20 , C07D317/66 , C07D333/20 , C07D333/34 , C07D335/02 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/10 , C07D413/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D491/04 , C07D491/08 , C07D498/08
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
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公开(公告)号：US08383623B2
公开(公告)日：2013-02-26
申请号：US13086580
申请日：2011-04-14
Applicant: Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
Inventor： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
IPC: A01N43/58 , A61K31/50 , C07D237/30
CPC classification number: C07D471/04 , C07D401/04
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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公开(公告)号：US20110257189A1
公开(公告)日：2011-10-20
申请号：US13086556
申请日：2011-04-14
Applicant: Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
Inventor： Gui-Dong Zhu , Virajkumar B. Gandhi , Alexander R. Shoemaker , Thomas D. Penning , Jianchun Gong
IPC: A61K31/4985 , A61P35/00 , C07D487/04
CPC classification number: C07D487/04 , C07D519/00
Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1a, R1b, R1c, X, Y, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as Cdc7 and methods of treating diseases such as cancer.
Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中R1a，R1b，R1c，X，Y，Z，n和m在说明书中定义。 本发明还涉及含有所述化合物的组合物，其可用于抑制诸如Cdc7的激酶和治疗诸如癌症的疾病的方法。
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