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公开(公告)号：US20080293675A1
公开(公告)日：2008-11-27
申请号：US11971693
申请日：2008-01-09
申请人： Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
发明人： Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
CPC分类号： C07F5/025
摘要： The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
摘要翻译： 公开了包含硼酸络合物的抗生素的结构和制备，特别是羟基喹啉，咪唑和吡啶甲酸衍生物，以及这些抗生素的组合物以及使用抗生素和组合物作为杀菌和杀真菌剂的方法以及用于治疗 细菌和真菌引起的疾病。
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公开(公告)号：US20050070503A1
公开(公告)日：2005-03-31
申请号：US10867465
申请日：2004-06-14
申请人： Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
发明人： Ving Lee , Stephen Benkovic , Stephen Baker , Kirk Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
CPC分类号： C07F5/025
摘要： The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
摘要翻译： 公开了包含硼酸络合物的抗生素的结构和制备，特别是羟基喹啉，咪唑和吡啶甲酸衍生物，以及这些抗生素的组合物以及使用抗生素和组合物作为杀菌和杀真菌剂的方法以及用于治疗 细菌和真菌引起的疾病。
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公开(公告)号：US20050054644A1
公开(公告)日：2005-03-10
申请号：US10868268
申请日：2004-06-15
申请人： Ving Lee , Jacob Plattner , Stephen Benkovic , Stephen Baker , Kirk Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro
发明人： Ving Lee , Jacob Plattner , Stephen Benkovic , Stephen Baker , Kirk Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro
IPC分类号： A61K20060101 , A61K31/498 , A61K31/53 , A61K31/69 , C07D471/02 , C07D487/02 , C07F5/02
CPC分类号： C07F5/025
摘要： Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由细菌或病毒引起的疾病的治疗剂的硼烷衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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4.发明申请公开(公告)号：US20070265226A1
公开(公告)日：2007-11-15
申请号：US11743665
申请日：2007-05-02
申请人： Ving Lee , Jacob Plattner , Stephen Benkovic , Stephen Baker , Kirk Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro
发明人： Ving Lee , Jacob Plattner , Stephen Benkovic , Stephen Baker , Kirk Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio Sauro
CPC分类号： C07F5/025
摘要： Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由真菌，酵母，细菌或病毒引起的疾病的治疗剂的硼衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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公开(公告)号：US07390806B2
公开(公告)日：2008-06-24
申请号：US10867465
申请日：2004-06-14
申请人： Ving Lee , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
发明人： Ving Lee , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
IPC分类号： C07D484/04 , C07D215/02 , C07D215/20 , C07D239/70 , C07D253/08 , A61K31/47 , A61P31/04 , A61P31/10
CPC分类号： C07F5/025
摘要： The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
摘要翻译： 公开了包含硼酸络合物的抗生素的结构和制备，特别是羟基喹啉，咪唑和吡啶甲酸衍生物，以及这些抗生素的组合物以及使用抗生素和组合物作为杀菌和杀真菌剂的方法以及用于治疗 细菌和真菌引起的疾病。
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公开(公告)号：US07888356B2
公开(公告)日：2011-02-15
申请号：US11971693
申请日：2008-01-09
申请人： Ving Lee , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Tsutomu Akama , Yong-Kang Zhang , Rajesjwar Singh , Vittorio A. Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
发明人： Ving Lee , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Tsutomu Akama , Yong-Kang Zhang , Rajesjwar Singh , Vittorio A. Sauro , Chetan Pandit , Zhuoyi Su , Zhixiang Yang
IPC分类号： A61K31/47 , A61P31/04 , A61P31/10 , C07D487/04 , C07D215/02 , C07D239/70 , C07D253/08
CPC分类号： C07F5/025
摘要： The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.
摘要翻译： 公开了包含硼酸络合物的抗生素的结构和制备，特别是羟基喹啉，咪唑和吡啶甲酸衍生物，以及这些抗生素的组合物以及使用抗生素和组合物作为杀菌和杀真菌剂的方法以及用于治疗 细菌和真菌引起的疾病。
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公开(公告)号：US07465836B2
公开(公告)日：2008-12-16
申请号：US10868268
申请日：2004-06-15
申请人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
发明人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
IPC分类号： C07F9/02
CPC分类号： C07F5/025
摘要： Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由细菌或病毒引起的疾病的治疗剂的硼烷衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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公开(公告)号：US07968752B2
公开(公告)日：2011-06-28
申请号：US12270636
申请日：2008-11-13
申请人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
发明人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
IPC分类号： C07F9/02
CPC分类号： C07F5/025
摘要： Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由细菌或病毒引起的疾病的治疗剂的硼烷衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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9.发明申请公开(公告)号：US20090239824A1
公开(公告)日：2009-09-24
申请号：US12270636
申请日：2008-11-13
申请人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
发明人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
CPC分类号： C07F5/025
摘要： Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由细菌或病毒引起的疾病的治疗剂的硼烷衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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10.发明授权公开(公告)号：US08106031B2
公开(公告)日：2012-01-31
申请号：US11743665
申请日：2007-05-02
申请人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
发明人： Ving Lee , Jacob J. Plattner , Stephen J. Benkovic , Stephen J. Baker , Kirk R. Maples , Carolyn Bellinger-Kawahara , Tsutomu Akama , Yong-Kang Zhang , Rajeshwar Singh , Vittorio A. Sauro
CPC分类号： C07F5/025
摘要： Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
摘要翻译： 公开了用于治疗由真菌，酵母，细菌或病毒引起的疾病的治疗剂的硼衍生物，包括苯并恶唑，苯并唑并苯并噻唑的组合物和方法，以及合成所述试剂及其组合物的方法。
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