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公开(公告)号:US08143284B2
公开(公告)日:2012-03-27
申请号:US11867369
申请日:2007-10-04
IPC分类号: A61K31/4985 , C07D401/08
CPC分类号: C07D209/44 , C07D209/46 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06
摘要: Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
摘要翻译: 公开了抑制聚(ADP-核糖)聚合酶活性的化合物,含有化合物的组合物和使用该化合物治疗疾病的方法。
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公开(公告)号:US20120258180A1
公开(公告)日:2012-10-11
申请号:US13442294
申请日:2012-04-09
申请人: Vincent Louis Giranda , Alexander R. Shoemaker , Kaitlin E. Browman , Shailen K. Joshi , Jill-desiree Brederson , Thomas D. Penning
发明人: Vincent Louis Giranda , Alexander R. Shoemaker , Kaitlin E. Browman , Shailen K. Joshi , Jill-desiree Brederson , Thomas D. Penning
IPC分类号: A61K31/4184 , A61K33/24 , A61P25/02 , A61K31/437
CPC分类号: C07D403/04 , A61K31/337 , A61K31/4184 , A61K31/475 , A61K31/555 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要: The present invention relates to the method of treating chemotherapy-induced neuropathy in a subject in need thereof with the use of a poly(ADP-ribose)polymerase (PARP) inhibitor.
摘要翻译: 本发明涉及使用聚(ADP-核糖)聚合酶(PARP)抑制剂治疗有需要的受试者的化疗诱发的神经病变的方法。
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公开(公告)号:US06495562B1
公开(公告)日:2002-12-17
申请号:US09842382
申请日:2001-04-25
申请人: Milan Bruncko , Christopher Robin Dalton , Vincent Louis Giranda , Jianchun Gong , Willian J. McClellan , Vicki L. Nienaber , Todd Warren Rockway , Daryl Richard Sauer , Moshe Weitzberg
发明人: Milan Bruncko , Christopher Robin Dalton , Vincent Louis Giranda , Jianchun Gong , Willian J. McClellan , Vicki L. Nienaber , Todd Warren Rockway , Daryl Richard Sauer , Moshe Weitzberg
IPC分类号: C07D21302
CPC分类号: C07D401/06 , C07D217/04 , C07D405/04
摘要: Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions, methods for the preparation of urokinase-inhibitors, and a method of inhibiting urokinase in a mammal.
摘要翻译: 具有该化学式的化合物是尿激酶的抑制剂,并且可用于治疗尿激酶起作用的疾病。 还公开了尿激酶抑制组合物,尿激酶抑制剂的制备方法和抑制哺乳动物尿激酶的方法。
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