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    Methods and apparatus for determining analytes in various matrices
    1.
    发明授权
    Methods and apparatus for determining analytes in various matrices 失效
    用于确定各种基质中分析物的方法和装置

    公开(公告)号：US06852289B2

    公开(公告)日：2005-02-08

    申请号：US09817446

    申请日：2001-03-26

    申请人： Virginia C. Gordon ,  Bennett W. Root, Jr. ,  Barbara J. Peasley ,  John F. Elias ,  John T. Sorensen ,  Michael Mittelstein ,  Soheila Mirhashemi

    发明人： Virginia C. Gordon ,  Bennett W. Root, Jr. ,  Barbara J. Peasley ,  John F. Elias ,  John T. Sorensen ,  Michael Mittelstein ,  Soheila Mirhashemi

    IPC分类号： B01L3/00 ,  G01N33/52 ,  G01N33/543 ,  B01L11/00 ,  B01D24/00 ,  C12M3/00

    CPC分类号： B01L3/5025 ,  B01L3/50255 ,  G01N33/52 ,  G01N33/54366 ,  Y10T436/173845 ,  Y10T436/18

    摘要： Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included. Additionally, there's provided an embodiment of above-described invention for determination of an analyte which is present in a matrix at low (e.g., sub-detectable) levels, wherein the filter of the apparatus is utilized to capture and concentrate the analyte, to provide a filtrate-reagent admixture wherein the analyte is present at detectable concentration.

    摘要翻译： 用于定性或定量测定诸如食品，生物流体等的基质中的一种或多种分析物的方法和装置。用于测定单个分析物的实施方案包括样品接收容器，第一膜和含有试剂的孔。 制备的样品通过第一膜，除去外来物质，并且滤液进入含试剂的孔中以提供可以从其中测定分析物的滤液 - 试剂混合物。 用于测定多个分析物的实施方案包括与第一膜串联的一个或多个另外的膜，每个这样的附加膜可操作以捕获一种或多种分析物。 然后可以将每种附加分析物从其已被捕获的膜上洗脱出来，以分离含有试剂的孔，以提供洗脱剂 - 试剂混合物，从中可以确定每种所需的分析物。 还包括制剂添加剂的配方。 此外，提供了上述发明的一个实施方案，用于测定在低（例如，亚可检测）水平下存在于基质中的分析物，其中该装置的过滤器用于捕获和浓缩分析物，以提供 滤液 - 试剂混合物，其中分析物以可检测的浓度存在。

    Methods and apparatus for determining specific analytes in foods and other complex matrices
    2.
    发明授权
    Methods and apparatus for determining specific analytes in foods and other complex matrices 失效
    用于确定食品和其他复杂基质中特定分析物的方法和设备

    公开(公告)号：US06489132B1

    公开(公告)日：2002-12-03

    申请号：US09388974

    申请日：1999-09-02

    申请人： Virginia C. Gordon ,  John T. Sorensen ,  Soheila Mirhashemi ,  Michael Mittelstein ,  John F. Elias

    发明人： Virginia C. Gordon ,  John T. Sorensen ,  Soheila Mirhashemi ,  Michael Mittelstein ,  John F. Elias

    IPC分类号： G01N3353

    CPC分类号： G01N33/54366 ,  G01N33/52 ,  Y10S210/908 ,  Y10S436/824 ,  Y10S436/825 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

    摘要： Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included. Additionally, there's provided an embodiment of above-described invention for determination of an analyte which is present in a matrix at low (e.g., sub-detectable) levels, wherein the filter of the apparatus is utilized to capture and concentrate the analyte, to provide a filtrate-reagent admixture wherein the analyte is present at a detectable concentration.

    摘要翻译： 用于定性或定量测定诸如食品，生物流体等的基质中的一种或多种分析物的方法和装置。用于测定单个分析物的实施方案包括样品接收容器，第一膜和含有试剂的孔。 制备的样品通过第一膜，除去外来物质，并且滤液进入含试剂的孔中以提供可以从其中测定分析物的滤液 - 试剂混合物。 用于测定多个分析物的实施方案包括与第一膜串联的一个或多个另外的膜，每个这样的附加膜可操作以捕获一种或多种分析物。 然后可以将每种附加分析物从其已被捕获的膜上洗脱出来，以分离含有试剂的孔，以提供洗脱剂 - 试剂混合物，从中可以确定每种所需的分析物。 还包括制剂添加剂的配方。 此外，提供了上述发明的一个实施方案，用于测定在低（例如，亚可检测）水平下存在于基质中的分析物，其中该装置的过滤器用于捕获和浓缩分析物，以提供 滤液 - 试剂混合物，其中分析物以可检测的浓度存在。

    Test kits for determining at least two specific analytes in foods and other complex matrices
    3.
    发明授权
    Test kits for determining at least two specific analytes in foods and other complex matrices 失效
    用于确定食品和其他复杂基质中至少两种特异性分析物的测试工具

    公开(公告)号：US5958714A

    公开(公告)日：1999-09-28

    申请号：US723636

    申请日：1996-10-02

    申请人： Virginia C. Gordon ,  John T. Sorensen ,  Soheila Mirhashemi ,  Michael Mittelstein ,  John F. Elias

    发明人： Virginia C. Gordon ,  John T. Sorensen ,  Soheila Mirhashemi ,  Michael Mittelstein ,  John F. Elias

    IPC分类号： G01N33/566 ,  G01N33/52 ,  G01N33/53 ,  G01N33/538 ,  G01N33/543

    CPC分类号： G01N33/54366 ,  G01N33/52 ,  Y10S210/908 ,  Y10S436/824 ,  Y10S436/825 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

    摘要： Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte comprises a sample receiving vessel, a first membrane and a reagent-containing well. The prepared sample passes through the first membrane whereby extraneous matter is removed, and a filtrate enters the reagent-containing well to provide a filtrate-reagent admixture from which the analyte may be determined. An embodiment for determination for multiple analytes includes one or more additional membranes in series with the first membrane, each such additional membrane being operative to capture one or more analytes. Each of the additional analytes may then be eluted from the membrane upon which it has been captured, into a separate reagent-containing well to provide eluant-reagent admixture from which each desired analyte may be determined. Formulations for preparation additives are also included. Additionally, there's provided an embodiment of above-described invention for determination of an analyte which is present in a matrix at low (e.g., sub-detectable) levels, wherein the filter of the apparatus is utilized to capture and concentrate the analyte, to provide a filtrate-reagent admixture wherein the analyte is present at detectable concentration.

    摘要翻译： 用于定性或定量测定诸如食品，生物流体等的基质中的一种或多种分析物的方法和装置。用于测定单个分析物的实施方案包括样品接收容器，第一膜和含有试剂的孔。 制备的样品通过第一膜，除去外来物质，并且滤液进入含试剂的孔中以提供可以从其中测定分析物的滤液 - 试剂混合物。 用于测定多个分析物的实施方案包括与第一膜串联的一个或多个另外的膜，每个这样的附加膜可操作以捕获一种或多种分析物。 然后可以将每种附加分析物从其已被捕获的膜上洗脱出来，以分离含有试剂的孔，以提供洗脱剂 - 试剂混合物，从中可以确定每种所需的分析物。 还包括制剂添加剂的配方。 此外，提供了上述发明的一个实施方案，用于测定在低（例如，亚可检测）水平下存在于基质中的分析物，其中该装置的过滤器用于捕获和浓缩分析物，以提供 滤液 - 试剂混合物，其中分析物以可检测的浓度存在。

    Inverted peristaltic pumps and related methods
    5.
    发明授权
    Inverted peristaltic pumps and related methods 有权

    公开(公告)号：US06655934B2

    公开(公告)日：2003-12-02

    申请号：US10102608

    申请日：2002-03-20

    申请人： Michael Mittelstein ,  John T. Sorensen ,  Soheila Mirhashemi

    发明人： Michael Mittelstein ,  John T. Sorensen ,  Soheila Mirhashemi

    IPC分类号： F04B4308

    CPC分类号： F04B43/1261

    摘要： Inverted peristaltic pumps and related apparatus/methods wherein one or more compressible pump tubes are formed or mounted on a core member and one or more tube compressing members move about the core member so as to compress the tube(s) and propel a fluid through the tube(s). The core member may be removable and the pump tube(s) may be pre-mounted on the core member to form a disposable or reusable tubing cartridge. The core member or tubing cartridge may be easily inserted into and removed from the pump. In some embodiments troughs or grooves may be formed on the core member and the tube(s) may be disposed in such troughs or grooves.

    Methods, apparatus and system for removal of lenses from mammalian eyes
    6.
    发明授权
    Methods, apparatus and system for removal of lenses from mammalian eyes 有权
    用于从哺乳动物眼睛去除镜片的方法，装置和系统

    公开(公告)号：US06506176B1

    公开(公告)日：2003-01-14

    申请号：US09505098

    申请日：2000-02-16

    申请人： Michael Mittelstein ,  John T. Sorensen ,  Soheila Mirhashemi ,  James B. Gerg ,  John I. Muri ,  Roger F. Etherington ,  John A. Ripley

    发明人： Michael Mittelstein ,  John T. Sorensen ,  Soheila Mirhashemi ,  James B. Gerg ,  John I. Muri ,  Roger F. Etherington ,  John A. Ripley

    IPC分类号： A61F900

    CPC分类号： A61F9/00763 ,  A61F9/013

    摘要： A system for removing the lens from an eye of a mammal, including a lens-removal device having a probe for penetrating the lens capsule. The probe includes a sheath that shields a rotating impeller at all times, with the impeller being pneumatically actuated to advance to a lens removal position within the sheath. The impeller is pneumatically rotated using a turbine mechanism within a handle for the probe. Irrigation and aspiration are provided to facilitate removal of the lens tissue. The turbine is driven with pulsed air to prevent stiction. A purge/protection cap helps remove air bubbles from the system prior to use and protects the delicate impeller during transport. An operating system is also provided with a foot pedal actuator.

    摘要翻译： 一种用于从哺乳动物的眼睛移除透镜的系统，包括具有用于穿透透镜胶囊的探针的透镜去除装置。 探头包括一个护罩，其一直屏蔽旋转的叶轮，其中叶轮被气动地驱动以前进到护套内的透镜去除位置。 叶轮在用于探针的手柄内使用涡轮机构气动旋转。 提供灌溉和抽吸以便于去除透镜组织。 涡轮机用脉冲空气驱动以防止静摩擦。 吹扫/保护帽有助于在使用前清除系统中的气泡，并在运输过程中保护细密的叶轮。 操作系统还设置有脚踏板致动器。

    Rotary device for removing ophthalmic lens
    9.
    发明授权
    Rotary device for removing ophthalmic lens 失效
    用于去除眼科镜片的旋转装置

    公开(公告)号：US5690641A

    公开(公告)日：1997-11-25

    申请号：US421421

    申请日：1995-04-11

    申请人： John T. Sorensen ,  Michael Mittelstein ,  Soheila Mirhashemi

    发明人： John T. Sorensen ,  Michael Mittelstein ,  Soheila Mirhashemi

    IPC分类号： A61B17/00 ,  A61F9/00 ,  A61F9/007 ,  A61F9/013

    CPC分类号： A61F9/00763 ,  A61B2017/00685

    摘要： A system and method for reducing and removing and ophthalmic lens of a mammalian eye. The system includes a rotary lens-reducing probe device of either straight or curved configuration, said probe device comprising a tubular outer sheath through which a rotatable drive shaft extends. A rotating lens-reducing head member is positioned on the distal end of the drive shaft. The head member is configured and constructed to draw a flow of fluid and lens matter into contact therewith, thereby facilitating complete reduction of the entire lens without requiring significant axial (i.e., longitudinal) movement of the probe within the lens capsule. The distal portion of the tubular sheath is preferably configured to shield a portion of the lens-reducing head, during operation, to avoid inadvertent damage to lens capsule. Also, the distal portion of the sheath may be aimed or positioned to direct the flow of fluid and lens matter created by the rotating head in a preferred flow path within the lens capsule. The device may incorporate means for infusing and/or withdrawing fluid and/or debris into/from the eye.

    摘要翻译： 用于减少和去除哺乳动物眼睛的眼科镜片的系统和方法。 该系统包括直的或弯曲构造的旋转透镜减小探针装置，所述探针装置包括管状的外护套，可旋转的驱动轴通过其延伸。 旋转透镜减小头部件位于驱动轴的远端。 头部构件被构造和构造成将流体和透镜物质的流动与其接触，从而有助于整个透镜的完全减少，而不需要在透镜囊内显着的轴向（即纵向）移动探针。 管状护套的远侧部分优选地构造成在操作期间屏蔽透镜减少头部的一部分，以避免对透镜胶囊的无意的损坏。 此外，鞘的远端部分可以被瞄准或定位成将由旋转头产生的流体和透镜物质的流动引导到镜片胶囊内的优选流动路径中。 该装置可以包括用于将流体和/或碎屑注入和/或从眼睛中注入的装置。

    Systems and methods for measuring pressure
    10.
    发明授权
    Systems and methods for measuring pressure 有权
    用于测量压力的系统和方法

    公开(公告)号：US06820490B2

    公开(公告)日：2004-11-23

    申请号：US10273379

    申请日：2002-10-16

    申请人： Michael Mittelstein ,  John T. Sorensen ,  James B. Gerg ,  Soheila Mirhashemi

    发明人： Michael Mittelstein ,  John T. Sorensen ,  James B. Gerg ,  Soheila Mirhashemi

    IPC分类号： G01L708

    CPC分类号： G01L19/0645 ,  A61M1/3641 ,  G01L9/0064 ,  G01L19/0023 ,  G01L19/003

    摘要： Methods and systems for measuring the pressure of a fluid. A flexible barrier separates the fluid from the pressure receiving surface of a pressure sensing device. The pressure of the fluid is transferred through the flexible barrier to the pressure receiving surface. The flexible barrier may be in abutting juxtaposition with or may be spaced apart from the pressure sensing surface. In either case, the flexible barrier is coupled or held in defined relationship to the pressure sensing surface such that the pressure receiving surface will receive the substantially actual pressure of the fluid even when the pressure of the fluid is less than the ambient atmospheric pressure. Coupling of the flexible barrier to the pressure receiving surface may be achieved by any suitable means, including adhesive or the application of a full or partial vacuum between the flexible barrier and the pressure receiving surface.

    摘要翻译： 用于测量流体压力的方法和系统。 柔性屏障将流体与压力感测装置的压力接收表面分开。 流体的压力通过柔性屏障转移到压力接收表面。 柔性屏障可以与压力感测表面邻接并置或与压力感测表面间隔开。 在任一种情况下，柔性屏障耦合或保持与压力感测表面的限定关系，使得即使当流体的压力小于环境大气压力时，压力接收表面也将接收流体的基本上实际的压力。 柔性屏障与压力接收表面的耦合可以通过任何合适的方式实现，包括粘合剂或在柔性屏障和压力接收表面之间施加全部或部分真空。