公开(公告)号：US20100081610A1

公开(公告)日：2010-04-01

申请号：US12438182

申请日：2007-08-21

申请人： Viswajanani J. Sattigeri ,  Venkata P. Palle ,  Manoj Kumar Khera ,  Ranaheer Reddy ,  Manoj Kumar Tiwari ,  Ajay Soni ,  Abdul Rehman Abdul Rauf ,  Sony Joseph ,  Arpita Musib ,  Sunanda G. Dastidar ,  Punit Kumar Srivastava

发明人： Viswajanani J. Sattigeri ,  Venkata P. Palle ,  Manoj Kumar Khera ,  Ranaheer Reddy ,  Manoj Kumar Tiwari ,  Ajay Soni ,  Abdul Rehman Abdul Rauf ,  Sony Joseph ,  Arpita Musib ,  Sunanda G. Dastidar ,  Punit Kumar Srivastava

IPC分类号： A61K38/13 ,  C07D253/08 ,  A61K31/53 ,  C07D401/02 ,  A61K31/4439 ,  C07D209/44 ,  A61K31/404 ,  A61K31/5415 ,  A61K31/56 ,  C07D277/00 ,  A61P29/00 ,  A61P37/06

CPC分类号： A61K31/4155 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/502 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/536 ,  A61K45/06 ,  C07D209/44 ,  C07D209/48 ,  C07D253/08 ,  C07D265/26 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D405/10 ,  C07D409/06 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10

摘要： The present invention relates to β-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.

摘要翻译： 本发明涉及作为基质金属蛋白酶抑制剂，特别是非对映体纯的β-羟基羧酸的羟基和氨基取代的羧酸，用于合成含有本发明化合物的药物组合物的相应方法。 本发明的化合物可用于治疗各种炎性，自身免疫性和过敏性疾病，例如治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，牛皮癣关节炎，牛皮癣，肺纤维化，伤口愈合障碍，肺部炎症， 急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他炎症性疾病，其特征在于过度表达和过度激活 使用该化合物的基质金属蛋白酶。

公开(公告)号：US08507670B2

公开(公告)日：2013-08-13

申请号：US12438182

申请日：2007-08-21

申请人： Viswajanani J. Sattigeri ,  Venkata P. Palle ,  Manoj Kumar Khera ,  Ranadheer Reddy ,  Manoj Kumar Tiwari ,  Ajay Soni ,  Abdul Rehman Abdul Rauf ,  Sony Joseph ,  Arpita Musib ,  Sunanda G. Dastidar ,  Punit Kumar Srivastava

发明人： Viswajanani J. Sattigeri ,  Venkata P. Palle ,  Manoj Kumar Khera ,  Ranadheer Reddy ,  Manoj Kumar Tiwari ,  Ajay Soni ,  Abdul Rehman Abdul Rauf ,  Sony Joseph ,  Arpita Musib ,  Sunanda G. Dastidar ,  Punit Kumar Srivastava

IPC分类号： C07D253/08 ,  A61K31/53 ,  A61P19/02

CPC分类号： A61K31/4155 ,  A61K31/4035 ,  A61K31/41 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/502 ,  A61K31/506 ,  A61K31/517 ,  A61K31/53 ,  A61K31/536 ,  A61K45/06 ,  C07D209/44 ,  C07D209/48 ,  C07D253/08 ,  C07D265/26 ,  C07D401/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D405/10 ,  C07D409/06 ,  C07D409/10 ,  C07D409/14 ,  C07D413/10

摘要： The present invention relates to β-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.

摘要翻译： 本发明涉及β-羟基和氨基取代的羧酸，其作为基质金属蛋白酶抑制剂，特别是非对映体纯的β-羟基羧酸，用于合成的相应方法和含有本发明化合物的药物组合物。 本发明的化合物可用于治疗各种炎性，自身免疫性和过敏性疾病，例如治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，牛皮癣关节炎，牛皮癣，肺纤维化，伤口愈合障碍，肺部炎症， 急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他炎症性疾病，其特征在于过度表达和过度激活 使用该化合物的基质金属蛋白酶。