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公开(公告)号：US08507670B2
公开(公告)日：2013-08-13
申请号：US12438182
申请日：2007-08-21
申请人： Viswajanani J. Sattigeri , Venkata P. Palle , Manoj Kumar Khera , Ranadheer Reddy , Manoj Kumar Tiwari , Ajay Soni , Abdul Rehman Abdul Rauf , Sony Joseph , Arpita Musib , Sunanda G. Dastidar , Punit Kumar Srivastava
发明人： Viswajanani J. Sattigeri , Venkata P. Palle , Manoj Kumar Khera , Ranadheer Reddy , Manoj Kumar Tiwari , Ajay Soni , Abdul Rehman Abdul Rauf , Sony Joseph , Arpita Musib , Sunanda G. Dastidar , Punit Kumar Srivastava
IPC分类号： C07D253/08 , A61K31/53 , A61P19/02
CPC分类号： A61K31/4155 , A61K31/4035 , A61K31/41 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/536 , A61K45/06 , C07D209/44 , C07D209/48 , C07D253/08 , C07D265/26 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10
摘要： The present invention relates to β-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, periodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.
摘要翻译： 本发明涉及β-羟基和氨基取代的羧酸，其作为基质金属蛋白酶抑制剂，特别是非对映体纯的β-羟基羧酸，用于合成的相应方法和含有本发明化合物的药物组合物。 本发明的化合物可用于治疗各种炎性，自身免疫性和过敏性疾病，例如治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，牛皮癣关节炎，牛皮癣，肺纤维化，伤口愈合障碍，肺部炎症， 急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他炎症性疾病，其特征在于过度表达和过度激活 使用该化合物的基质金属蛋白酶。
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公开(公告)号：US20100081610A1
公开(公告)日：2010-04-01
申请号：US12438182
申请日：2007-08-21
申请人： Viswajanani J. Sattigeri , Venkata P. Palle , Manoj Kumar Khera , Ranaheer Reddy , Manoj Kumar Tiwari , Ajay Soni , Abdul Rehman Abdul Rauf , Sony Joseph , Arpita Musib , Sunanda G. Dastidar , Punit Kumar Srivastava
发明人： Viswajanani J. Sattigeri , Venkata P. Palle , Manoj Kumar Khera , Ranaheer Reddy , Manoj Kumar Tiwari , Ajay Soni , Abdul Rehman Abdul Rauf , Sony Joseph , Arpita Musib , Sunanda G. Dastidar , Punit Kumar Srivastava
IPC分类号： A61K38/13 , C07D253/08 , A61K31/53 , C07D401/02 , A61K31/4439 , C07D209/44 , A61K31/404 , A61K31/5415 , A61K31/56 , C07D277/00 , A61P29/00 , A61P37/06
CPC分类号： A61K31/4155 , A61K31/4035 , A61K31/41 , A61K31/438 , A61K31/4439 , A61K31/444 , A61K31/502 , A61K31/506 , A61K31/517 , A61K31/53 , A61K31/536 , A61K45/06 , C07D209/44 , C07D209/48 , C07D253/08 , C07D265/26 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10
摘要： The present invention relates to β-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure β-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.
摘要翻译： 本发明涉及作为基质金属蛋白酶抑制剂，特别是非对映体纯的β-羟基羧酸的羟基和氨基取代的羧酸，用于合成含有本发明化合物的药物组合物的相应方法。 本发明的化合物可用于治疗各种炎性，自身免疫性和过敏性疾病，例如治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，牛皮癣关节炎，牛皮癣，肺纤维化，伤口愈合障碍，肺部炎症， 急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他炎症性疾病，其特征在于过度表达和过度激活 使用该化合物的基质金属蛋白酶。
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公开(公告)号：US20130021906A1
公开(公告)日：2013-01-24
申请号：US13598468
申请日：2012-08-29
CPC分类号： H04L47/10 , H04L41/0681 , H04L41/0893 , H04L41/5009 , H04L41/5019 , H04L41/5067 , H04L43/026 , H04L43/0817
摘要： A plurality of flow network elements monitors network flows at the subscriber level for a plurality of subscribers. The flow network elements export flow records to a collector, which organizes the flow records. A policy client correlates the flow records and determines whether any network flows are violating a flow policy definition. If a flow policy definition is violated, the policy client transmits a policy action to a policy server which indicates what action to take for a given violating flow. The policy server assigns a flow policy for the subscriber corresponding with the violating flow. The assigned flow policy is then transmitted to the flow network element having that violating flow, and that flow network element installs the flow policy.
摘要翻译： 多个流网络元件监视订户级别的多个用户的网络流。 流网络元素将流记录导出到收集器，它收集流记录。 策略客户端将流记录相关联，并确定任何网络流是否违反流策略定义。 如果流策略定义被违反，则策略客户端向策略服务器发送策略动作，该策略服务器指示针对给定的违规流采取什么动作。 策略服务器为与违反流相对应的用户分配流策略。 然后将分配的流策略发送到具有该违反流的流网络元件，并且该流网络元件安装该流策略。
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公开(公告)号：US20100188976A1
公开(公告)日：2010-07-29
申请号：US12360080
申请日：2009-01-26
IPC分类号： H04L12/56
CPC分类号： H04L47/10 , H04L41/0681 , H04L41/0893 , H04L41/5009 , H04L41/5019 , H04L41/5067 , H04L43/026 , H04L43/0817
摘要： A plurality of flow network elements monitors network flows at the subscriber level for a plurality of subscribers. The flow network elements export flow records to a collector, which organizes the flow records. A policy client correlates the flow records and determines whether any network flows are violating a flow policy definition. If a flow policy definition is violated, the policy client transmits a policy action to a policy server which indicates what action to take for a given violating flow. The policy server assigns a flow policy for the subscriber corresponding with the violating flow. The assigned flow policy is then transmitted to the flow network element having that violating flow, and that flow network element installs the flow policy.
摘要翻译： 多个流网络元件监视订户级别的多个用户的网络流。 流网络元素将流记录导出到收集器，它收集流记录。 策略客户端将流记录相关联，并确定任何网络流是否违反流策略定义。 如果流策略定义被违反，则策略客户端向策略服务器发送策略动作，该策略服务器指示针对给定的违规流采取什么动作。 策略服务器为与违反流相对应的用户分配流策略。 然后将分配的流策略发送到具有该违反流的流网络元件，并且该流网络元件安装该流策略。
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公开(公告)号：US08274895B2
公开(公告)日：2012-09-25
申请号：US12360080
申请日：2009-01-26
IPC分类号： G01R31/08
CPC分类号： H04L47/10 , H04L41/0681 , H04L41/0893 , H04L41/5009 , H04L41/5019 , H04L41/5067 , H04L43/026 , H04L43/0817
摘要： A plurality of flow network elements monitors network flows at the subscriber level for a plurality of subscribers. The flow network elements export flow records to a collector, which organizes the flow records. A policy client correlates the flow records and determines whether any network flows are violating a flow policy definition. If a flow policy definition is violated, the policy client transmits a policy action to a policy server which indicates what action to take for a given violating flow. The policy server assigns a flow policy for the subscriber corresponding with the violating flow. The assigned flow policy is then transmitted to the flow network element having that violating flow, and that flow network element installs the flow policy.
摘要翻译： 多个流网络元件监视订户级别的多个用户的网络流。 流网络元素将流记录导出到收集器，它收集流记录。 策略客户端将流记录相关联，并确定任何网络流是否违反流策略定义。 如果流策略定义被违反，则策略客户端向策略服务器发送策略动作，该策略服务器指示针对给定的违规流采取什么动作。 策略服务器为与违反流相对应的用户分配流策略。 然后将分配的流策略发送到具有该违反流的流网络元件，并且该流网络元件安装该流策略。
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