公开(公告)号：US20130018110A1

公开(公告)日：2013-01-17

申请号：US13574053

申请日：2011-01-20

申请人： Vitaliy Khutoryanskiy ,  Olga Khutoryanskaya ,  Joseph Peter Cook ,  Glenn William Goodall

发明人： Vitaliy Khutoryanskiy ,  Olga Khutoryanskaya ,  Joseph Peter Cook ,  Glenn William Goodall

IPC分类号： C08L29/04 ,  C08K3/20 ,  C08L33/02 ,  C08L35/08 ,  C08L33/26 ,  C08L33/24 ,  A61K47/32 ,  C08J3/24

CPC分类号： C08J3/075 ,  C08J2329/00 ,  C08J2329/04 ,  C08J2333/00 ,  C08J2339/00

摘要： The invention provides a method for preparing a hydrogel from a hydrophilic polymer having one or more functional groups which are capable of co-reacting in a condensation reaction which method comprises the steps of: (i) preparing a solution of the polymer; (ii) heating the solution to a temperature sufficient for the condensation reaction to take place for a period of time sufficient for the hydrogel to cross-link wherein where the hydrophilic polymer comprises a first and a second hydrophilic polymer, step (i) comprises a step of mixing the hydrophilic polymers to prepare a homogeneous intimate mixture of the polymers; and wherein the heating step (ii) is carried out at a pressure greater than atmospheric pressure. The method of the invention is advantageous because it is relatively low cost, it is a safer procedure with less health & safety concerns, it is carried out in a liquid state and is not limited by film thickness.

摘要翻译： 本发明提供了一种从具有一个或多个能够在缩合反应中共反应的官能团的亲水聚合物制备水凝胶的方法，该方法包括以下步骤：（i）制备聚合物溶液; （ii）将溶液加热到足以使缩合反应发生足以使水凝胶交联的时间，其中亲水性聚合物包含第一和第二亲水性聚合物，其中步骤（i）包括 混合亲水性聚合物以制备聚合物均匀的紧密混合物的步骤; 并且其中所述加热步骤（ii）在大于大气压的压力下进行。 本发明的方法是有利的，因为它的成本相对较低，它是一种更安全的方法，具有较少的健康和安全性，它以液体状态进行并且不受膜厚度的限制。