公开(公告)号：US4016223A

公开(公告)日：1977-04-05

申请号：US602735

申请日：1975-08-07

申请人： Vithal J. Rajadhyaksha ,  Richard A. Schroer ,  Phillip J. Brock ,  Earl R. Krueger

发明人： Vithal J. Rajadhyaksha ,  Richard A. Schroer ,  Phillip J. Brock ,  Earl R. Krueger

IPC分类号： C07C45/74 ,  C07C45/75 ,  C07C49/835 ,  C07C205/45 ,  C07F9/12 ,  C07F9/09 ,  A01N9/36

CPC分类号： C07C205/45 ,  C07C45/74 ,  C07C45/75 ,  C07C49/835 ,  C07F9/12

摘要： Novel prostaglandin dehydrogenase inhibiting agents having the structural formula ##STR1## M is H or a pharmaceutically acceptable salt, X is hydrogen, dialkylaminomethyl, lower alkyl, lower alkoxy, aryl, substituted aryl, halogen, cyano, nitro, trihaloalkyl, --NR.sub.1 R.sub.2 or --NHCOR.sub.1 where R.sub.1 and R.sub.2 are hydrogen, lower alkyl or NH.sub.2 and n is 0-5.

摘要翻译： 具有结构式M的新型前列腺素脱氢酶抑制剂是H或其药学上可接受的盐，X是氢，二烷基氨基甲基，低级烷基，低级烷氧基，芳基，取代的芳基，卤素，氰基，硝基，三卤代烷基， NR1R2或-NHCOR1，其中R1和R2是氢，低级烷基或NH2，n是0-5。

公开(公告)号：US4038415A

公开(公告)日：1977-07-26

申请号：US719432

申请日：1976-09-01

申请人： Vithal J. Rajadhyaksha ,  Richard A. Schroer ,  Phillip J. Brock ,  Earl R. Krueger

发明人： Vithal J. Rajadhyaksha ,  Richard A. Schroer ,  Phillip J. Brock ,  Earl R. Krueger

IPC分类号： A61K31/12 ,  A61K31/165 ,  A61K31/19

CPC分类号： A61K31/165 ,  A61K31/12

摘要： Novel prostaglandin dehydrogenase inhibiting agents having the structural formula ##STR1## X is hydroxyl, dialkylaminomethyl, lower alkyl, lower alkoxy, aryl, substituted aryl, halogen, cyano, nitro, trihaloalkyl, --NR.sub.1 R.sub.2 or --NHCOR.sub.1 where R.sub.1 and R.sub.2 are hydrogen, lower alkyl or NH.sub.2 and n is 0-5.