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公开(公告)号：US4762549A
公开(公告)日：1988-08-09
申请号：US484027
申请日：1983-04-11
IPC分类号： A01N25/02 , A01N43/36 , A01N43/40 , A01N43/46 , A01N57/20 , A61F5/41 , A61K47/22 , C05F11/10
CPC分类号： C05F11/10 , A01N25/02 , A01N43/36 , A01N43/40 , A01N43/46 , A01N57/20 , A61K47/22 , A61F2005/415
摘要： The disclosure describes compositions and methods for improved delivery of plant growth regulators comprising contacting a plant with a composition comprising an effective amount of a plant growth regulator and an effective delivery enhancing amount of compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group having 1-4 carbon atoms, m is 3-7, n is 0-17 and R is --CH.sub.3, ##STR2## where R" is H or halogen, with the proviso that if m is 3 and R is CH.sub.3, then n is 5-17.
摘要翻译： 本公开描述了用于改进植物生长调节剂递送的组合物和方法，其包括使植物与包含有效量的植物生长调节剂和有效递送量的具有结构式其中R'是H的化合物或 具有1-4个碳原子的低级烷基，m为3-7，n为0-17，R为-CH 3，其中R“为H或卤素，条件是如果m为3，R 是CH3，那么n是5-17。
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公开(公告)号：US4444762A
公开(公告)日：1984-04-24
申请号：US327999
申请日：1981-12-07
IPC分类号： A61K8/49 , A61K9/00 , A61K47/22 , A61Q19/00 , A61K31/30 , A61K31/505 , A61K31/70 , A61K31/71
CPC分类号： A61K9/0014 , A61K47/22 , A61K8/4906 , A61Q17/005 , A61Q19/00 , A61Q17/02 , A61Q17/04 , Y10S514/947
摘要： Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.
摘要翻译： 用于携带生理活性剂如治疗剂的组合物通过皮肤和其他体膜包含该试剂和有效的无毒量的具有结构式的化合物，其中R'是H或低级烷基，m 是3-7，N是0-17，R是-CH 3，苯基或取代的苯基或者IMAGE，条件是如果m是3并且R是-CH 3，那么n不是0-6。
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公开(公告)号：US4423040A
公开(公告)日：1983-12-27
申请号：US327998
申请日：1981-12-07
IPC分类号： A61K8/49 , A61K9/00 , A61K31/505 , A61K31/573 , A61K47/22 , A61Q19/00 , A61K31/56 , A61K31/10 , A61K31/71
CPC分类号： A61K9/0014 , A61K47/22 , A61K8/4906 , A61Q17/005 , A61Q19/00 , A61Q17/02 , A61Q17/04 , Y10S514/859 , Y10S514/863 , Y10S514/934 , Y10S514/947
摘要： Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.
摘要翻译： 用于携带生理活性剂如治疗剂的组合物通过皮肤和其他体膜包含该试剂和有效的无毒量的具有结构式的化合物，其中R'是H或低级烷基，m 是3-7，N是0-17，R是-CH 3，苯基或取代的苯基或者IMAGE，条件是如果m是3并且R是-CH 3，那么n不是0-6。
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公开(公告)号：US4316893A
公开(公告)日：1982-02-23
申请号：US137248
申请日：1980-04-04
IPC分类号： A61F5/41 , A61K8/49 , A61K9/00 , A61K31/55 , A61K47/22 , A61L15/44 , A61Q19/00 , A61K31/30 , A61K31/505 , A61K31/70 , A61K31/71
CPC分类号： A61K9/0014 , A61K47/22 , A61K8/4906 , A61Q17/005 , A61Q19/00 , A61F2005/415 , A61Q17/02 , A61Q17/04
摘要： Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3-7, N is 0-17 and R is --CH.sub.3, phenyl or substituted phenyl or ##STR2## with the proviso that if m is 3 and R is --CH.sub.3, then n is not 0-6.
摘要翻译： 用于携带生理活性剂如治疗剂的组合物通过皮肤和其他体膜包含该试剂和有效的无毒量的具有结构式的化合物，其中R'是H或低级烷基，m 是3-7，N是0-17，R是-CH 3，苯基或取代的苯基或者IMAGE，条件是如果m是3并且R是-CH 3，那么n不是0-6。
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公开(公告)号：US4016223A
公开(公告)日：1977-04-05
申请号：US602735
申请日：1975-08-07
IPC分类号： C07C45/74 , C07C45/75 , C07C49/835 , C07C205/45 , C07F9/12 , C07F9/09 , A01N9/36
CPC分类号： C07C205/45 , C07C45/74 , C07C45/75 , C07C49/835 , C07F9/12
摘要： Novel prostaglandin dehydrogenase inhibiting agents having the structural formula ##STR1## M is H or a pharmaceutically acceptable salt, X is hydrogen, dialkylaminomethyl, lower alkyl, lower alkoxy, aryl, substituted aryl, halogen, cyano, nitro, trihaloalkyl, --NR.sub.1 R.sub.2 or --NHCOR.sub.1 where R.sub.1 and R.sub.2 are hydrogen, lower alkyl or NH.sub.2 and n is 0-5.
摘要翻译： 具有结构式M的新型前列腺素脱氢酶抑制剂是H或其药学上可接受的盐，X是氢，二烷基氨基甲基，低级烷基，低级烷氧基，芳基，取代的芳基，卤素，氰基，硝基，三卤代烷基， NR1R2或-NHCOR1，其中R1和R2是氢，低级烷基或NH2，n是0-5。
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公开(公告)号：US5204339A
公开(公告)日：1993-04-20
申请号：US563863
申请日：1990-08-06
CPC分类号： A01N25/02 , A01N37/18 , A61K47/22 , A61K9/0014 , A61K9/7023 , C05G3/00 , Y10S514/946 , Y10S514/947
摘要： This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein X is selected from the group consisting of oxygen and sulfur; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-17 and R is --CH.sub.3 ; wherein R is H or a lower alkyl group, m is 5-7 and n is 0-17.
摘要翻译： 本发明涉及一种通过透皮装置或制剂的人和动物的皮肤或粘膜施用全身活性剂的方法，所述方法包括与所述全身药剂局部施用有效量的具有结构式的膜渗透增强剂， 图像>其中X选自氧和硫; R'是H或具有1-4个碳原子的低级烷基; m为2-6; n为0-17，R为-CH 3; 其中R为H或低级烷基，m为5-7，n为0-17。
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公开(公告)号：US4405616A
公开(公告)日：1983-09-20
申请号：US380161
申请日：1982-05-20
IPC分类号： A61K9/06 , A61F5/41 , A61K8/49 , A61K9/00 , A61K31/395 , A61K31/445 , A61K47/22 , A61L15/44 , A61Q19/00 , B01J19/00 , A61K31/33
CPC分类号： A61K9/0014 , A61K47/22 , A61K8/4906 , A61Q19/00 , A61F2005/415 , Y10S514/947
摘要： In a method for administering systemically active agents including therapeutic agents through the skin or other body membranes of humans and animals typically in the form of a transdermal device or formulation, the improvement comprising the use therewith of an effective amount of a membrane penetration enhancer having the structural formula. ##STR1## wherein R is H or a lower alkyl group, m is 5-7 and n is 0-17.
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公开(公告)号：US4006204A
公开(公告)日：1977-02-01
申请号：US572888
申请日：1975-04-30
CPC分类号： C07F9/4087 , C07F9/094
摘要： The invention relates to compounds represented by the following general structure: ##STR1## and their method of making. These compounds are therapeutically useful as anti-inflammatory agents and operate as inhibitors of prostaglandin synthetase and also as prostaglandin receptor blockers.
摘要翻译： 本发明涉及由以下一般结构表示的化合物：
及其制备方法。 这些化合物在治疗上可用作抗炎剂并作为前列腺素合成酶的抑制剂和前列腺素受体阻断剂起作用。 -
9.发明授权Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers for physiological active agents 失效包含氨基醇衍生物作为生理活性剂的膜渗透增强剂的组合物和方法
公开(公告)号：US5482965A
公开(公告)日：1996-01-09
申请号：US115772
申请日：1993-09-03
IPC分类号： A61K47/16 , A61K8/41 , A61K8/44 , A61K8/49 , A61K9/00 , A61K31/23 , A61K31/335 , A61K47/18 , A61K47/22 , A61Q7/00 , A61Q17/02 , A61Q19/00 , C07C233/18 , C07C233/28 , C07D319/06 , A61K31/27 , A61K31/16 , A61K31/22 , A61K31/225
CPC分类号： A61K9/0014 , A61K47/18 , A61K47/22 , A61K8/41 , A61K8/44 , A61K8/4953 , A61K8/498 , A61Q19/00 , C07C233/18 , C07C233/28 , C07D319/06 , A61Q17/02 , A61Q17/04 , A61Q7/00 , A61Q9/04 , Y10S514/946 , Y10S514/947
摘要： A method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeutically effective amount of a pharmaceutically active agent and a non-toxic, effective amount of penetration enhancing agent of the formula I or a physiologically acceptable salt thereof: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein.
摘要翻译： 一种用于增强局部或全身用途的透皮装置或制剂中通过人和动物的皮肤和粘膜吸收局部施用的生理活性剂的方法和组合物，其包含治疗有效量的药物活性剂和无毒的 ，有效量的式I的渗透增强剂或其生理上可接受的盐：其中：R1，R2，R3和R4如本文所定义。
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10.发明授权
公开(公告)号：US5283343A
公开(公告)日：1994-02-01
申请号：US718342
申请日：1991-06-18
IPC分类号： A61K31/40 , C07D209/16
CPC分类号： A61K31/40
摘要： This invention relates to novel melatonin derivatives, such as 2-aryl substituted N-acetyltryptamines, having pharmacological activity, e.g., melatonin antagonist activity, and methods for the synthesis thereof.
摘要翻译： 本发明涉及具有药理学活性的新的褪黑激素衍生物，例如具有药理学活性的2-芳基取代的N-乙酰基色胺，例如褪黑激素拮抗剂活性，及其合成方法。
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