公开(公告)号：US20180265554A1

公开(公告)日：2018-09-20

申请号：US15571175

申请日：2016-05-04

申请人： WAGENINGEN UNIVERSITEIT ,  UNIVERSITE CATHOLIQUE DE LOUVAIN

发明人： Clara BELZER ,  Willem Meindert DE VOS ,  Patrice Daniel CANI

IPC分类号： C07K14/195 ,  A61P3/06 ,  A61P3/08

摘要： It has been found that an extracellular polypeptide derived from Akkermansia municiphila is capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide or host cells including such polypeptide may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.

公开(公告)号：US20210147489A1

公开(公告)日：2021-05-20

申请号：US16916459

申请日：2020-06-30

申请人： WAGENINGEN UNIVERSITEIT ,  UNIVERSITÉ CATHOLIQUE DE LOUVAIN

发明人： Clara BELZER ,  Willem Meindert DE VOS ,  Patrice Daniel CANI

IPC分类号： C07K14/195 ,  A61P3/08 ,  A61P3/06 ,  C12N1/20

摘要： It has been found that an extracellular polypeptide derived from Akkermansia municiphila is capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide or host cells comprising such polypeptide may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.