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公开(公告)号：US20210147489A1
公开(公告)日：2021-05-20
申请号：US16916459
申请日：2020-06-30
IPC分类号： C07K14/195 , A61P3/08 , A61P3/06 , C12N1/20
摘要： It has been found that an extracellular polypeptide derived from Akkermansia municiphila is capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide or host cells comprising such polypeptide may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.
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公开(公告)号：US20210188923A1
公开(公告)日：2021-06-24
申请号：US17193562
申请日：2021-03-05
IPC分类号： C07K14/195 , C12N1/20 , A61P3/08 , A61P3/06
摘要： A method for cost-effectively and efficiently culturing Akkermansia muciniphila is described. High biomass yields can be obtained on chemically defined media. This allows for large scale production of A. muciniphila suitable for use in humans, such as for pharmaceutical or food applications. The A. muciniphila can be produced free of animal-derived products, thereby allowing a broad-range of applications.
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公开(公告)号：US20180265554A1
公开(公告)日：2018-09-20
申请号：US15571175
申请日：2016-05-04
IPC分类号： C07K14/195 , A61P3/06 , A61P3/08
摘要： It has been found that an extracellular polypeptide derived from Akkermansia municiphila is capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide or host cells including such polypeptide may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.
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公开(公告)号：US20170252421A1
公开(公告)日：2017-09-07
申请号：US15506948
申请日：2015-08-28
CPC分类号： A61K39/0208 , A61K2039/505 , A61K2039/542 , A61K2039/55505 , A61K2039/58 , C07K16/1203 , C07K2317/76
摘要： Compounds disclosed herein are effective against Ralstonia pickettii for treating or preventing insulin resistance, obesity or type II diabetes of a subject, and include an antibiotic effective against Ralstonia pickettii, an immunogenic compound producing a protective immune response, or an antibody which specifically binds to Ralstonia pickettii or a fragment thereof. In vitro methods for diagnosis or prediction of insulin resistance, obesity or type II diabetes include determining the presence of Ralstonia pickettii or of an antibody which specifically binds to Ralstonia pickettii in a test sample. An antibody binding specifically to an antigen of Ralstonia pickettii, a Ralstonia pickettii cell, or a nucleic acid hybridizing under stringent conditions to a nucleic acid from Ralstonia pickettii is disclosed. A kit including said antibody, the nucleic acid, and optionally a Ralstonia pickettii bacteria or a nucleic acid or protein thereof, a further reagent or a conventional kit component, is also disclosed.
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公开(公告)号：US20220228105A1
公开(公告)日：2022-07-21
申请号：US17615705
申请日：2020-08-14
IPC分类号： C12N1/20 , A61P3/10 , A61K35/742
摘要： The invention is concerned with a bacterium comprising a inositol to propionic acid pathway gene set that allows said bacterium to convert inositol to propionic acid or a salt or ester thereof. The bacterium can be used as a probiotic or supplement to promote production of propionic acid in the GI tract, thereby preventing and/or treating conditions or diseases that benefit from the production of propionic acid, for example metabolic disease, metabolic syndrome, insulin resistance or insulin resistance-related conditions, particularly dyslipidemia, type 2 diabetes mellitus and insulin-resistance in endocrine diseases.
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公开(公告)号：US20190183941A1
公开(公告)日：2019-06-20
申请号：US16093041
申请日：2017-04-10
IPC分类号： A61K35/741 , C12R1/01
CPC分类号： C12R1/01 , A61K35/741 , C12N1/20
摘要： A novel Akkermansia species has been isolated from fresh faeces obtained from the reticulated python. The species has been named Akkermansia glycaniphilus. It is capable of growing on mucus as a sole carbon and nitrogen source. The species can be used as a medicament, probiotic or cosmetic, e.g., for promoting weight loss, for promoting gut mucosal immune system function, for maintaining, restoring and/or increasing the physical integrity of the gut mucosal barrier, and for prevention or treatment of a variety of associated diseases or disorders.
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公开(公告)号：US20180094233A1
公开(公告)日：2018-04-05
申请号：US15572126
申请日：2016-05-04
IPC分类号： C12N1/20
CPC分类号： C07K14/195 , A61K38/00 , A61P3/06 , A61P3/08 , C12N1/20
摘要： A method for cost-effectively and efficiently culturing Akkermansia muciniphilais is disclosed. High biomass yields can be obtained on chemically defined media. This allows for large scale production of A. muciniphila suitable for use in humans, such as for pharmaceutical or food applications. The A. muciniphila can be produced free of animal-derived products, thereby allowing a broad-range of applications.
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