公开(公告)号：US11230702B2

公开(公告)日：2022-01-25

申请号：US16322232

申请日：2017-08-04

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Robert T. Wicks ,  Anthony Atala ,  Goodwell Nzou ,  Elizabeth E. Wicks

IPC: C12N5/071 ,  C12N5/00

Abstract: Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.

公开(公告)号：US20220106572A1

公开(公告)日：2022-04-07

申请号：US17643441

申请日：2021-12-09

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Robert T. Wicks ,  Anthony Atala ,  Goodwell Nzou ,  Elizabeth E. Wicks

IPC: C12N5/071 ,  C12N5/00

Abstract: Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.

公开(公告)号：US20190194625A1

公开(公告)日：2019-06-27

申请号：US16322232

申请日：2017-08-04

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Robert T. Wicks ,  Anthony Atala ,  Goodwell Nzou ,  Elizabeth E. Wicks

IPC: C12N5/071 ,  C12N5/00

CPC classification number: C12N5/0697 ,  C12N5/0062 ,  C12N5/0691 ,  C12N2502/081 ,  C12N2502/086 ,  C12N2502/28 ,  C12N2506/45 ,  C12N2513/00 ,  C12N2533/54 ,  C12N2537/10

Abstract: Provided herein is an in vitro model of the blood brain barrier. In some embodiments, the model includes: an endothelial cell layer, and brain tissue layer comprising neuronal cells, and optionally one or more of astrocytes, pericytes, oligodendrocytes, and microglia. In some embodiments, the model further comprises a porous membrane between said endothelial cell layer and the neuronal cell layer. A microfluidic device comprising the same and methods of use thereof are also provided.