公开(公告)号：US12076419B2

公开(公告)日：2024-09-03

申请号：US16907748

申请日：2020-06-22

Applicant: Wright State University

Inventor： Hongmei Ren

IPC: A61K48/00 ,  A61K31/165 ,  A61K31/203 ,  A61K31/4439 ,  A61K35/76 ,  A61K35/761 ,  A61K35/763 ,  A61K38/46 ,  A61K47/32 ,  A61P21/00

CPC classification number: A61K48/0058 ,  A61K31/165 ,  A61K31/203 ,  A61K31/4439 ,  A61K35/76 ,  A61K35/761 ,  A61K35/763 ,  A61P21/00 ,  A61K38/465 ,  A61K47/32 ,  C12N2750/14143 ,  C12Y301/03004

Abstract: Methods for treatment of Duchenne's muscular dystrophy and several clinically related conditions in subjects in need thereof are provided. In further aspects, methods are provided for decreasing muscle degeneration in a subject in need thereof. In even further aspects, methods of enhancing sarcolemma stability and or/integrity in muscle cells lacking functional dystrophin in a subject in need thereof are provided. In aspects, the above-methods comprise administering a therapeutically effective amount of a composition suitable for increasing expression of a LPIN1 gene or a lipin-1 protein levels in a muscle cell of said subject; and decreasing muscle degeneration and improving exercise endurance and muscle contractile force in said subject by said step of administering.

公开(公告)号：US20200017916A1

公开(公告)日：2020-01-16

申请号：US16428517

申请日：2019-05-31

Applicant: WRIGHT STATE UNIVERSITY

Inventor： Hongmei Ren

IPC: C12Q1/6886

Abstract: A method using genome-wide methylation profiling to investigate DNA methylation alterations in peripheral blood t for the diagnosis, prognosis, and/or prediction of therapy outcome of colorectal cancer (CRC). Use of accurate non-invasive biomarkers may be used to facilitate the early diagnosis of CRC.