公开(公告)号：US12076419B2

公开(公告)日：2024-09-03

申请号：US16907748

申请日：2020-06-22

Applicant: Wright State University

Inventor： Hongmei Ren

IPC: A61K48/00 ,  A61K31/165 ,  A61K31/203 ,  A61K31/4439 ,  A61K35/76 ,  A61K35/761 ,  A61K35/763 ,  A61K38/46 ,  A61K47/32 ,  A61P21/00

CPC classification number: A61K48/0058 ,  A61K31/165 ,  A61K31/203 ,  A61K31/4439 ,  A61K35/76 ,  A61K35/761 ,  A61K35/763 ,  A61P21/00 ,  A61K38/465 ,  A61K47/32 ,  C12N2750/14143 ,  C12Y301/03004

Abstract: Methods for treatment of Duchenne's muscular dystrophy and several clinically related conditions in subjects in need thereof are provided. In further aspects, methods are provided for decreasing muscle degeneration in a subject in need thereof. In even further aspects, methods of enhancing sarcolemma stability and or/integrity in muscle cells lacking functional dystrophin in a subject in need thereof are provided. In aspects, the above-methods comprise administering a therapeutically effective amount of a composition suitable for increasing expression of a LPIN1 gene or a lipin-1 protein levels in a muscle cell of said subject; and decreasing muscle degeneration and improving exercise endurance and muscle contractile force in said subject by said step of administering.

公开(公告)号：US20210397904A1

公开(公告)日：2021-12-23

申请号：US17305105

申请日：2021-06-30

Applicant: BAYLR RESEARCH INSTITUTE ,  WRIGHT STATE UNIVERSITY

Inventor： Themistocles DASSOPOULOS ,  Nikolaos BOURBAKIS

IPC: G06K9/62 ,  G16H50/50 ,  G16H50/20 ,  G16H30/40 ,  G06F16/583 ,  G06N20/00 ,  G06K9/20 ,  G06N5/04 ,  G06T7/00 ,  G06T11/00

Abstract: Computational techniques are applied to video images of polyps to extract features and patterns from different perspectives of a polyp. The extracted features and patterns are synthesized using registration techniques to remove artifacts and noise, thereby generating improved images for the polyp. The generated images of each polyp can be used for training and testing purposes, where a machine learning system separates two types of polyps.

公开(公告)号：US20200168762A1

公开(公告)日：2020-05-28

申请号：US16665358

申请日：2019-10-28

Applicant: Wright State University

Inventor： Elliott R. Brownj ,  Weidong Zhang ,  Tyler Growden ,  Paul Berger ,  David Storm ,  David Meyer

IPC: H01L33/06 ,  H01L29/20 ,  C02F1/32 ,  H01L33/12 ,  H01L33/00 ,  H01S5/042 ,  H01S5/02 ,  H01S5/187 ,  H01S5/14 ,  H01S5/343 ,  H01L33/32 ,  H01L29/88 ,  H01S5/34

Abstract: Gallium nitride based devices and, more particularly to the generation of holes in gallium nitride based devices lacking p-type doping, and their use in light emitting diodes and lasers, both edge emitting and vertical emitting. By tailoring the intrinsic design, a wide range of wavelengths can be emitted from near-infrared to mid ultraviolet, depending upon the design of the adjacent cross-gap recombination zone. The innovation also provides for novel circuits and unique applications, particularly for water sterilization.

公开(公告)号：US20200017916A1

公开(公告)日：2020-01-16

申请号：US16428517

申请日：2019-05-31

Applicant: WRIGHT STATE UNIVERSITY

Inventor： Hongmei Ren

IPC: C12Q1/6886

Abstract: A method using genome-wide methylation profiling to investigate DNA methylation alterations in peripheral blood t for the diagnosis, prognosis, and/or prediction of therapy outcome of colorectal cancer (CRC). Use of accurate non-invasive biomarkers may be used to facilitate the early diagnosis of CRC.

公开(公告)号：US20190231269A1

公开(公告)日：2019-08-01

申请号：US16332248

申请日：2017-10-05

Applicant: Caroline CAO ,  WRIGHT STATE UNIVERSITY

Inventor： Caroline CAO

IPC: A61B5/00 ,  G01L1/24 ,  A61M25/09 ,  A61B5/06

CPC classification number: A61B5/6851 ,  A61B5/0093 ,  A61B5/065 ,  A61B5/6862 ,  A61B2562/0266 ,  A61M25/09 ,  G01L1/242 ,  G02B6/3624

Abstract: A sensorized surgical tool including a fiber optic shape tracking sensor for endovascular applications and methods of making the same.

公开(公告)号：US20170299609A1

公开(公告)日：2017-10-19

申请号：US15490094

申请日：2017-04-18

Applicant: Wright State University

Inventor： Sherif Elbasiouny

IPC: G01N33/68 ,  A61K31/522 ,  A61K31/712 ,  C12N15/85

CPC classification number: C12N15/8509 ,  A61K31/428 ,  A61K31/506 ,  A61K31/519 ,  C12N2015/8527 ,  C12N2015/8536

Abstract: Methods for treating amyotrophic lateral sclerosis (ALS). The methods include administering to a subject in need thereof a therapeutically effective amount of at least one small conductance calcium-activated potassium (SK) channel activator or a pharmaceutically acceptable salt or solvate thereof. Pharmaceutical compositions for the treatment of ALS, including a therapeutically effective amount of at least one SK channel activator, or a pharmaceutically acceptable salt or solvate thereof, and at least one excipient, adjuvant, or pharmaceutically acceptable carrier.

公开(公告)号：US09740662B2

公开(公告)日：2017-08-22

申请号：US14469171

申请日：2014-08-26

Applicant: Wright State University

Inventor： Jeffrey R. Smigelski

IPC: G06F7/00 ,  G06F17/14

CPC classification number: G06F17/141

Abstract: Generation of standardized noise signals that provide mathematically correct noise with no errors and no loss of data, and can generate the noise of specific environments based on the transfer function of that environment are discussed. Various embodiments can generate synthetic data sets based on natural data sets that have similar scaling behavior. Fractional scaling digital filters, containing the fractional scaling characteristics of one or more of the eleven fundamental forms of basic building block transfer functions which incorporate the scaling exponent, can be encoded on FPGA devices or DSP chips for use in digital signal processing. Fractional Scaling Digital Filters allow fractional calculus, and thus fractional filtering (e.g., fractional scaling, fractional phase shifting, fractional integration, or fractional differentiation), to be performed on any signal, represent exact filtering solutions rather than approximations, and demonstrably are extremely accurate, highly efficient, and exhibit a higher level of performance than traditional DSP filters.

公开(公告)号：US20170112824A1

公开(公告)日：2017-04-27

申请号：US15332292

申请日：2016-10-24

Applicant: Wright State University

Inventor： Yong-Jie Xu ,  Amanpreet Singh

IPC: A61K31/4745 ,  A61K31/17 ,  A61K31/4174 ,  A61K31/4196 ,  A61K31/496 ,  A61K45/06 ,  A61K31/137

CPC classification number: A61K31/4745 ,  A61K31/137 ,  A61K31/17 ,  A61K31/4174 ,  A61K31/4196 ,  A61K31/496 ,  A61K45/06 ,  A61K2300/00

Abstract: Methods and pharmaceutical compositions for treating fungal infections in a patient via administration of hydroxyurea and an ergosterol synthesis inhibitor, hydroxyurea and a heme synthesis inhibitor, an ergosterol synthesis inhibitor and a heme synthesis inhibitor, or hydroxyurea, an ergosterol synthesis inhibitor, and a heme synthesis inhibitor.

公开(公告)号：US11342482B2

公开(公告)日：2022-05-24

申请号：US16665358

申请日：2019-10-28

Applicant: Wright State University ,  The Government of the United States of America, As Represented By The Secretary Of The Navy ,  OHIO STATE INNOVATION FOUNDATION

Inventor： Elliott R. Brown ,  Weidong Zhang ,  Tyler Growden ,  Paul Berger ,  David Storm ,  David Meyer

IPC: H01S5/34 ,  H01L33/06 ,  H01L29/88 ,  H01L33/32 ,  H01S5/343 ,  H01S5/14 ,  H01S5/187 ,  H01S5/02 ,  H01L33/00 ,  H01L33/12 ,  C02F1/32 ,  H01L29/20 ,  H01S5/042 ,  H01L33/50 ,  H01S5/183 ,  H01S5/30

Abstract: Gallium nitride based devices and, more particularly to the generation of holes in gallium nitride based devices lacking p-type doping, and their use in light emitting diodes and lasers, both edge emitting and vertical emitting. By tailoring the intrinsic design, a wide range of wavelengths can be emitted from near-infrared to mid ultraviolet, depending upon the design of the adjacent cross-gap recombination zone. The innovation also provides for novel circuits and unique applications, particularly for water sterilization.

公开(公告)号：US20220020896A1

公开(公告)日：2022-01-20

申请号：US17083286

申请日：2020-10-28

Applicant: Wright State University

Inventor： Elliott R. Brown ,  Weidong Zhang ,  Tyler Growden ,  Paul Berger

IPC: H01L33/00 ,  H01L33/14 ,  H01L33/06 ,  H01S5/343 ,  H01S5/347

Abstract: A unipolar-doped light emitting diode or laser diode is described. The diode includes a bottom region having an n-type layer, a top region having an n-type layer, and a middle region between the top and bottom regions having at least one material different from the top or bottom region forming two or more heterojunctions. The top and bottom regions create light emission by interband tunneling-induced photon emission. Systems including the unipolar-doped diode including LIDAR are also taught.