利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.027 秒)

    COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF
    3.
    发明申请
    COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF 有权
    关于一种突变型脱落孢子虫毒素的组合物及其方法

    公开(公告)号：US20150307563A1

    公开(公告)日：2015-10-29

    申请号：US14796741

    申请日：2015-07-10

    申请人： WYETH LLC

    发明人： Annaliesa Sybil Anderson ,  Maninder K. Sidhu ,  Robert G. K. Donald ,  Kathrin Ute Jansen ,  Narender K. Kalyan ,  Justin Keith Moran ,  Mark E. Ruppen ,  Michael James Flint

    IPC分类号： C07K14/33 ,  A61K39/08

    CPC分类号： C07K14/33 ,  A61K39/08 ,  C07K16/1282 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/1051 ,  C12N9/99 ,  C12N15/74

    摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.

    摘要翻译： 一方面，本发明涉及包含突变型艰难梭菌毒素A和/或突变型艰难梭菌毒素B的免疫原性组合物。每种突变毒素包括具有至少一个突变的葡糖基转移酶结构域和具有至少一个突变的半胱氨酸蛋白酶结构域 突变，相对于相应的野生型艰难梭菌毒素。 突变毒素还可以包括至少一个化学交联的氨基酸。 另一方面，本发明涉及结合所述免疫原性组合物的抗体或其结合片段。 在另外的方面，本发明涉及编码前述任何一种的分离的核苷酸序列，以及任何上述组合物的使用方法。

    Compositions relating to a mutant Clostridium difficile toxin and methods thereof
    6.
    发明授权
    Compositions relating to a mutant Clostridium difficile toxin and methods thereof 有权
    与突变型艰难梭菌毒素有关的组合物及其方法

    公开(公告)号：US09187536B1

    公开(公告)日：2015-11-17

    申请号：US14796741

    申请日：2015-07-10

    申请人： WYETH LLC

    发明人： Annaliesa Sybil Anderson ,  Maninder K. Sidhu ,  Robert G. K. Donald ,  Kathrin Ute Jansen ,  Narender K. Kalyan ,  Justin Keith Moran ,  Mark E. Ruppen ,  Michael James Flint

    IPC分类号： C12N9/10 ,  C07K14/33 ,  A61K39/00 ,  A61K39/08

    CPC分类号： C07K14/33 ,  A61K39/08 ,  C07K16/1282 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92 ,  C12N9/1051 ,  C12N9/99 ,  C12N15/74

    摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.

    摘要翻译： 一方面，本发明涉及包含突变型艰难梭菌毒素A和/或突变型艰难梭菌毒素B的免疫原性组合物。每种突变毒素包括具有至少一个突变的葡糖基转移酶结构域和具有至少一个突变的半胱氨酸蛋白酶结构域 突变，相对于相应的野生型艰难梭菌毒素。 突变毒素还可以包括至少一个化学交联的氨基酸。 另一方面，本发明涉及结合所述免疫原性组合物的抗体或其结合片段。 在另外的方面，本发明涉及编码前述任何一种的分离的核苷酸序列，以及任何上述组合物的使用方法。