-
公开(公告)号：US20110111015A1
公开(公告)日：2011-05-12
申请号：US12740608
申请日：2008-11-03
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
IPC分类号： A61K9/127 , A61K39/00 , A61K39/12 , A61K39/02 , A61K39/112 , A61K39/07 , A61K39/108 , A61K39/002 , A61K39/012 , A61K39/015 , A61P37/04 , A61P33/02
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD4Q. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译： 提供了包含TRAP多肽和包含TRAP多肽的肠炎沙门氏菌载体的疫苗。 疫苗还可以包括能够结合CD4Q的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。
-
公开(公告)号：US08956849B2
公开(公告)日：2015-02-17
申请号：US12740608
申请日：2008-11-03
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton , Said El-Ashram , John Barta , Guillermo Tellez
IPC分类号： C07H21/04 , C07H21/02 , C12N7/00 , C12N7/01 , C12N15/00 , C07K14/705 , C07K14/455 , A61K39/00
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , C07K14/455 , C07K14/70575 , C07K2319/03 , Y02A50/412
摘要： Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.
摘要翻译： 提供了包含TRAP多肽和包含TRAP多肽的肠炎沙门氏菌载体的疫苗。 疫苗还可以包括能够结合CD40的CD154多肽。 还提供了增强针对Apicomplexan寄生虫的免疫应答的方法和降低与Apicomplexan寄生虫感染相关的发病率的方法。
-
公开(公告)号：US20110027309A1
公开(公告)日：2011-02-03
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/00 , C12N15/63 , A61K39/02 , A61K39/145 , A61K39/112 , C12N1/21 , C12N15/64 , A61P37/04 , A61P31/16
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译： 本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。 还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。 还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。 公开了开发细菌疫苗载体的方法。 还公开了在细菌中产生无疤痕位点突变的方法。
-
公开(公告)号：US08604178B2
公开(公告)日：2013-12-10
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： C07H21/02 , A61K49/00 , A61K39/112
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译： 本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。 还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。 还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。 公开了开发细菌疫苗载体的方法。 还公开了在细菌中产生无疤痕位点突变的方法。
-
5.发明授权Compositions and methods of enhancing immune responses to flagellated bacterium 有权增强对鞭毛细菌的免疫应答的组合物和方法公开(公告)号：US09125854B2
公开(公告)日：2015-09-08
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/02 , A61K39/112 , A61K39/00
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译： 提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。 还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。
-
6.发明申请COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM 有权增强对细菌细菌的免疫反应的组合物和方法公开(公告)号：US20110159026A1
公开(公告)日：2011-06-30
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/112 , A61P37/04 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译： 提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。 还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.025 秒)
