公开(公告)号：US20030108891A1

公开(公告)日：2003-06-12

申请号：US10166984

申请日：2002-09-18

Applicant: Washington State University Research Foundation

Inventor： Rodney B. Croteau ,  Kevin D. Walker ,  Anne Schoendorf ,  Mark R. Wildung

IPC: C12Q001/68 ,  C07H021/04 ,  C12N009/10 ,  C12P021/02 ,  C12N005/06

CPC classification number: C12P17/02 ,  C12N9/1029

Abstract: Transacylase enzymes and the use of such enzymes to produce paclitaxel and related taxoids, as well as intermediates in the paclitaxel biosynthetic pathway, are disclosed. Also disclosed are nucleic acid sequences encoding such transacylase enzymes such as (but without limitation) C-13 phenylpropanoid side chain-CoA acyltransferase and benzoyl-CoA:3null-N-debenzoyl-2null-deoxytaxol N-benzoyltransferase.

Abstract translation: 公开了转酰胺酶和这种酶在紫杉醇生物合成途径中产生紫杉醇和相关紫杉烷以及中间体的用途。 还公开了编码这样的转酰酶的核酸序列，例如（但不限于）C-13苯丙素侧链-CoA酰基转移酶和苯甲酰辅酶A：3'-N-脱苯甲酰基-2'-脱氧塔考酚N-苯甲酰基转移酶。

公开(公告)号：US20040005562A9

公开(公告)日：2004-01-08

申请号：US10166984

申请日：2002-06-10

Applicant: Washington State University Research Foundation

Inventor： Rodney B. Croteau ,  Kevin D. Walker ,  Anne Schoendorf ,  Mark R. Wildung

IPC: C12Q001/68 ,  C07H021/04 ,  C12N009/10 ,  C12P021/02 ,  C12N005/06

CPC classification number: C12P17/02 ,  C12N9/1029

Abstract: Transacylase enzymes and the use of such enzymes to produce paclitaxel and related taxoids, as well as intermediates in the paclitaxel biosynthetic pathway, are disclosed. Also disclosed are nucleic acid sequences encoding such transacylase enzymes such as (but without limitation) C-13 phenylpropanoid side chain-CoA acyltransferase and benzoyl-CoA:3null-N-debenzoyl-2null-deoxytaxol N-benzoyltransferase.

Abstract translation: 公开了转酰胺酶和这种酶在紫杉醇生物合成途径中产生紫杉醇和相关紫杉烷以及中间体的用途。 还公开了编码这样的转酰酶的核酸序列，例如（但不限于）C-13苯丙素侧链-CoA酰基转移酶和苯甲酰辅酶A：3'-N-脱苯甲酰基-2'-脱氧塔考酚N-苯甲酰基转移酶。

公开(公告)号：US20020168745A1

公开(公告)日：2002-11-14

申请号：US09866570

申请日：2001-05-25

Applicant: Washington State University Research Foundation

Inventor： Rodney B. Croteau ,  Kevin D. Walker ,  Anne Schoendorf ,  Mark R. Wildung

IPC: A01K067/027 ,  A01K067/033 ,  C07H021/04 ,  C12N009/18 ,  C12N001/21 ,  C12N001/18 ,  C12P021/02 ,  C12N005/06

CPC classification number: C12P17/02 ,  C12N9/1029

Abstract: Transacylase enzymes and the use of such enzymes to produce Taxolnull, related taxoids, as well as intermediates in the Taxolnull biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the transacylase enzymes.

Abstract translation: 公开了转酰胺酶和这些酶在Taxol TM生物合成途径中产生Taxol TM，相关紫杉类以及中间体的用途。 还公开了编码转酰酶的核酸序列。

公开(公告)号：US20020138859A1

公开(公告)日：2002-09-26

申请号：US09866572

申请日：2001-05-25

Applicant: Washington State University Research Foundation

Inventor： Rodney B. Croteau ,  Kevin D. Walker ,  Anne N.M.N. Schoendorf ,  Mark R. Wildung

IPC: A01K067/00 ,  A01K067/027 ,  C12N009/18 ,  C07H021/04 ,  C12N001/18 ,  C12P021/02 ,  C12N005/06 ,  C07K016/40

CPC classification number: C12P17/02 ,  C12N9/1029

Abstract: Transacylase enzymes and the use of such enzymes to produce Taxolnull, related taxoids, as well as intermediates in the Taxolnull biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the transacylase enzymes.