公开(公告)号：US09567652B2

公开(公告)日：2017-02-14

申请号：US13957124

申请日：2013-08-01

申请人： Washington University

发明人： Herbert W. Virgin ,  David Wang ,  Joy Loh ,  Thad Stappenbeck ,  Guoyan Zhao ,  Larissa Thackray ,  Christine Yokoyama

IPC分类号： C12Q1/70 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00

CPC分类号： C12Q1/701 ,  C07K14/005 ,  C07K16/10 ,  C12N7/00 ,  C12N2770/12021 ,  C12N2770/12022 ,  C12N2770/12023

摘要： Novel murine astroviruses, and methods of detecting the viruses are disclosed. Also disclosed are uses of the viruses and infected animals as model systems for discovery and development of vaccines and therapies for diseases caused by or associated with astrovirus infection, including human astrovirus-based diseases.

摘要翻译： 公开了新型鼠星状病毒，以及检测病毒的方法。 还公开了病毒和感染动物的用途作为用于发现和开发用于由星状病毒感染引起或与星状病毒感染（包括基于人类星状病毒的疾病）相关的疾病的疫苗和治疗的模型系统。

公开(公告)号：US20190145961A1

公开(公告)日：2019-05-16

申请号：US16095666

申请日：2017-04-20

申请人： Washington University ,  St. Jude Children's Research Hospital

发明人： Herbert W. Virgin ,  Douglas R. Green ,  Jennifer Martinez

IPC分类号： G01N33/50

摘要： Compositions and methods are provided for modifying diagnosing and treating inflammatory disease. The methods and compositions can be used to ameliorate the effects of a deficiency in the LAP pathway for clearing dead cells. Thus, methods are further provided for modulating dead cell clearance using an effective amount of a pharmaceutical composition that targets the LAP pathway. Accordingly, pharmaceutical compositions that target the LAP pathway re provided herein. The methods and compositions described herein can be used to treat inflammatory disease, such as systemic lupus erythematosus (SLE).

公开(公告)号：US20150284814A1

公开(公告)日：2015-10-08

申请号：US14429559

申请日：2013-09-19

申请人： BETH ISRAEL DEACONESS MEDICAL CENTER, INC. ,  WASHINGTON UNIVERSITY

发明人： Dan Barouch ,  Herbert W. Virgin ,  David Wang ,  Guoyan Zhao ,  Larissa Thackray ,  Scott Handley ,  Rachel Presti

IPC分类号： C12Q1/70

CPC分类号： C12Q1/703 ,  A61K39/00 ,  C12N7/00 ,  C12N2710/10321 ,  C12N2710/20021 ,  C12N2710/22021 ,  C12N2720/00021 ,  C12N2750/14021 ,  C12N2750/14121 ,  C12N2770/16021 ,  C12N2770/32021 ,  C12N2770/32321 ,  C12Q2600/112 ,  C12Q2600/158

摘要： The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.

摘要翻译： 本发明涉及与慢病毒感染期间病毒，免疫缺陷和肠病的显着扩张相关的先前未描述的病毒。 本发明还提供了检测受试者中获得性免疫缺陷综合征（AIDS）或AIDS进展的方法，以及诊断受试者中的免疫缺陷或肠病的方法，以及鉴定治疗药物的方法。