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公开(公告)号：US20130295125A1
公开(公告)日：2013-11-07
申请号：US13827035
申请日：2013-03-14
发明人： John P. Sundberg , Joongho Joh , A. Bennett Jenson , Shin-Je Ghim
IPC分类号： C07K14/005 , A61D19/00 , C07K16/08 , C12Q1/70 , G01N33/569
CPC分类号： C07K14/005 , A61D19/00 , C07K16/084 , C12N7/00 , C12N2710/20021 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12Q1/708 , G01N33/56983 , G01N33/6893 , G01N2333/025
摘要： Methods and compositions for detecting MusPV, also known as MmuPv1, infection of a rodent subject are described according to aspects of the present invention. In specific aspects, the present invention relates to assays for detecting MusPV infection of a rodent subject; vaccine compositions for inducing an immunological response against MusPV in a rodent subject; methods of inducing an immunological response to MusPV in a rodent subject; isolated MusPV protein; isolated antibodies which specifically binds to an MusPV protein, a fragment or variant thereof; isolated recombinantly expressed MusPV proteins; expression constructs comprising a nucleic acid encoding an MusPV protein; host cells comprising the expression construct; and hybridoma cell lines expressing an anti-MusPV monoclonal antibody specific for MusPV.
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公开(公告)号：US06284532B1
公开(公告)日：2001-09-04
申请号：US09135241
申请日：1998-08-17
IPC分类号： C12N1537
CPC分类号： C07K14/005 , A61K39/00 , A61K49/0004 , C12N2710/20021 , C12N2710/20022 , G01N2333/025
摘要： A live, infective stock of a new human papillomavirus, HPV IU, is provided. HPV IU is related to but distinct from HPV MM7 and HPV LVX82. An isolated nucleic acid comprising the genome of HPV IU is also provided. Methods of using HPV IU to develop and test HPV vaccines and HPV antiviral agents are also provided.
摘要翻译： 提供了一种新的人乳头瘤病毒（HPV IU）的活的感染性股票。 HPV IU与HPV MM7和HPV LVX82相关但不同。 还提供了包含HPV IU基因组的分离的核酸。 还提供了使用HPV IU开发和测试HPV疫苗和HPV抗病毒剂的方法。
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公开(公告)号：US20130295553A1
公开(公告)日：2013-11-07
申请号：US13801516
申请日：2013-03-13
发明人： John P. Sundberg , Joongho Joh , A. Bennett Jenson , Shin-Je Ghim
CPC分类号： C07K14/005 , A61D19/00 , C07K16/084 , C12N7/00 , C12N2710/20021 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12Q1/708 , G01N33/56983 , G01N33/6893 , G01N2333/025
摘要： Methods and compositions for detecting MusPV, also known as MmuPv1, infection of a rodent subject are described according to aspects of the present invention. In specific aspects, the present invention relates to assays for detecting MusPV infection of a rodent subject; vaccine compositions for inducing an immunological response against MusPV in a rodent subject; methods of inducing an immunological response to MusPV in a rodent subject; isolated MusPV protein; isolated antibodies which specifically binds to an MusPV protein, a fragment or variant thereof; isolated recombinantly expressed MusPV proteins; expression constructs comprising a nucleic acid encoding an MusPV protein; host cells comprising the expression construct; and hybridoma cell lines expressing an anti-MusPV monoclonal antibody specific for MusPV.
摘要翻译： 根据本发明的方面描述了用于检测MusPV的方法和组合物，也称为MmuPv1，啮齿动物受试者的感染。 在具体方面，本发明涉及用于检测啮齿动物受试者的MusPV感染的测定法; 在啮齿动物受试者中诱导针对MusPV的免疫应答的疫苗组合物; 在啮齿动物受试者中诱导对MusPV的免疫应答的方法; 分离的MusPV蛋白; 分离的抗体，其特异性结合MusPV蛋白，其片段或变体; 分离的重组表达的MusPV蛋白; 包含编码MusPV蛋白的核酸的表达构建体; 包含表达构建体的宿主细胞; 和表达对MusPV特异性的抗MusPV单克隆抗体的杂交瘤细胞系。
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4.发明授权DNA coding for a peptide of a papilloma virus main capside protein and use thereof 失效编码乳头瘤病毒主要蛋白的肽的DNA及其用途
公开(公告)号：US6025163A
公开(公告)日：2000-02-15
申请号：US578634
申请日：1996-06-14
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/395 , A61P31/12 , C07K14/025 , C07K16/08 , C12N7/04 , C12N15/37 , C12Q1/68 , C12R1/92 , C12P21/06 , C12N15/00
CPC分类号： C12N7/00 , C07K14/005 , A61K38/00 , A61K39/00 , C12N2710/20021 , C12N2710/20022 , C12N2710/20023 , C12N2710/20061
摘要： This invention relates to a DNA encoding a peptide of a papilloma virus major capsid protein. Furthermore, this invention deals with a papilloma virus genome containing such a DNA. In addition, this invention concerns proteins encoded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof and the use thereof in diagnosis, treatment and vaccination.
摘要翻译： PCT No.PCT / EP95 / 01697 Sec。 371日期1996年6月14日第 102（e）日期1996年6月14日PCT提交1995年5月4日PCT公布。 公开号WO95 / 30754 日期：1995年11月16日本发明涉及编码乳头瘤病毒主要衣壳蛋白的肽的DNA。 此外，本发明涉及含有这种DNA的乳头瘤病毒基因组。 此外，本发明涉及由乳头瘤病毒基因组和病毒样颗粒编码的蛋白质以及针对其的抗体及其用途及其在诊断，治疗和疫苗接种中的用途。
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5.发明授权Human papilloma virus Type 57, a method for preparing expression products thereof 失效人类乳头状瘤病毒57型，其表达产物的制备方法
公开(公告)号：US5618694A
公开(公告)日：1997-04-08
申请号：US479401
申请日：1995-06-07
IPC分类号： C12P21/00 , A61K39/00 , A61K39/12 , A61K39/395 , A61K39/42 , C07K14/005 , C07K14/025 , C07K14/195 , C07K16/00 , C12N7/00 , C12N15/37 , C12P21/08 , C12N15/00
CPC分类号： C07K14/005 , C12N7/00 , A61K39/00 , C12N2710/20021 , C12N2710/20022
摘要： The invention describes the isolation for the first time of human papilloma virus (HPV) 57, the partial characterization of its genome and its cloning in pUC 19. This opens up a way of diagnosing those tumors (oral, genital and cutaneous tumors) which are associated with HPV 57.
摘要翻译： 本发明描述了人类乳头瘤病毒（HPV）57的首次分离，其基因组的部分表征及其在pUC19中的克隆。这打开了诊断这些肿瘤（口腔，生殖器和皮肤肿瘤）的方法， 与HPV 57相关。
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公开(公告)号：US20180148780A1
公开(公告)日：2018-05-31
申请号：US15575977
申请日：2016-05-20
申请人： University of Maryland, Baltimore , OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH
发明人： Kevin CULLEN , Nicholas AMBULOS , Jennifer TROYER
IPC分类号： C12Q1/6869 , C12Q1/70 , A61P31/20
CPC分类号： C12Q1/6869 , A61P31/20 , C12N2710/20021 , C12Q1/708 , C12Q2535/122 , G01N2333/025 , G01N2800/26
摘要： Disclosed herein are compositions and methods for detecting and diagnosing HPV in subjects. The method includes using Next Gen Sequencing for detecting HPV in a sample and determining the specific subtype of HPV infection based on the sequencing data.
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7.发明申请VIRUSES ASSOCIATED WITH IMMUNODEFICIENCY AND ENTEROPATHY AND METHODS USING SAME 有权与免疫缺陷病毒和肠系膜炎相关的病毒及其使用方法公开(公告)号：US20150284814A1
公开(公告)日：2015-10-08
申请号：US14429559
申请日：2013-09-19
发明人： Dan Barouch , Herbert W. Virgin , David Wang , Guoyan Zhao , Larissa Thackray , Scott Handley , Rachel Presti
IPC分类号： C12Q1/70
CPC分类号： C12Q1/703 , A61K39/00 , C12N7/00 , C12N2710/10321 , C12N2710/20021 , C12N2710/22021 , C12N2720/00021 , C12N2750/14021 , C12N2750/14121 , C12N2770/16021 , C12N2770/32021 , C12N2770/32321 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.
摘要翻译： 本发明涉及与慢病毒感染期间病毒，免疫缺陷和肠病的显着扩张相关的先前未描述的病毒。 本发明还提供了检测受试者中获得性免疫缺陷综合征（AIDS）或AIDS进展的方法，以及诊断受试者中的免疫缺陷或肠病的方法，以及鉴定治疗药物的方法。
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8.发明授权DNA coding for a peptide of a papilloma virus main capside protein and use thereof 失效编码乳头瘤病毒主要蛋白的肽的DNA及其用途公开(公告)号：US06395512B1
公开(公告)日：2002-05-28
申请号：US09430010
申请日：1999-10-29
IPC分类号： C12P2106
CPC分类号： C12N7/00 , A61K38/00 , A61K39/00 , C07K14/005 , C12N2710/20021 , C12N2710/20022 , C12N2710/20023 , C12N2710/20061
摘要： This invention relates to a DNA encoding a peptide of a papilloma virus major capsid protein. Furthermore, this invention deals with a papilloma virus genome containing such a DNA. In addition, this invention concerns proteins encoded by the papilloma virus genome and virus-like particles as well as antibodies directed thereagainst and the use thereof and the use thereof in diagnosis, treatment and vaccination.
摘要翻译： 本发明涉及编码乳头瘤病毒主要衣壳蛋白的肽的DNA。 此外，本发明涉及含有这种DNA的乳头瘤病毒基因组。 此外，本发明涉及由乳头瘤病毒基因组和病毒样颗粒编码的蛋白质以及针对其的抗体及其用途及其在诊断，治疗和疫苗接种中的用途。
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9.发明授权Human papilloma virus type 57, diagnosis of HPV 57 infections and method therefor 失效人类乳头状瘤病毒57型，诊断HPV57感染及其方法
公开(公告)号：US6127164A
公开(公告)日：2000-10-03
申请号：US488359
申请日：1995-06-07
IPC分类号： C12P21/00 , A61K39/00 , A61K39/12 , A61K39/395 , A61K39/42 , C07K14/005 , C07K14/025 , C07K14/195 , C07K16/00 , C12N7/00 , C12N15/37 , C12P21/08
CPC分类号： C07K14/005 , C12N7/00 , A61K39/00 , C12N2710/20021 , C12N2710/20022
摘要： The invention describes the isolation for the first time of human papilloma virus (HPV) 57, the partial characterization of its genome and its cloning in pUC 19. This opens up a way of diagnosing those tumors (oral, genital and cutaneous tumors) which are associated with HPV 57.
摘要翻译： 本发明描述了人类乳头瘤病毒（HPV）57的首次分离，其基因组的部分表征及其在pUC19中的克隆。这打开了诊断这些肿瘤（口腔，生殖器和皮肤肿瘤）的方法， 与HPV 57相关。
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公开(公告)号：US09683268B2
公开(公告)日：2017-06-20
申请号：US14429559
申请日：2013-09-19
发明人： Dan Barouch , Herbert W Virgin , David Wang , Guoyan Zhao , Larissa Thackray , Scott Handley , Rachel Presti
IPC分类号： C12Q1/70 , A61K39/235 , A61K39/21 , C12N7/00 , A61K39/00
CPC分类号： C12Q1/703 , A61K39/00 , C12N7/00 , C12N2710/10321 , C12N2710/20021 , C12N2710/22021 , C12N2720/00021 , C12N2750/14021 , C12N2750/14121 , C12N2770/16021 , C12N2770/32021 , C12N2770/32321 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.
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