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公开(公告)号：US11124562B2
公开(公告)日：2021-09-21
申请号：US16345637
申请日：2017-10-27
发明人： David Holtzman , Hong Jiang , Fan Liao , Thu Nga Bien-Ly , Mark S. Dennis , Jing Guo , Adam P. Silverman , Ryan J. Watts , Yin Zhang
摘要： The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of A plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
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公开(公告)号：US20220411485A1
公开(公告)日：2022-12-29
申请号：US17410686
申请日：2021-08-24
发明人： David Holtzman , Hong Jiang , Fan Liao , Thu Nga Bien-Ly , Mark S. Dennis , Jing Guo , Adam P. Silverman , Ryan J. Watts , Yin Zhang
IPC分类号： C07K16/18 , A61P25/28 , A61K9/00 , A61K9/127 , A61K31/192
摘要： The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
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公开(公告)号：US20190270794A1
公开(公告)日：2019-09-05
申请号：US16345637
申请日：2017-10-27
发明人： David Holtzman , Hong Jiang , Fan Liao , Thu Nga Bien-Ly , Mark S. Dennis , Jing Guo , Adam P. Silverman , Ryan J. Watts , Yin Zhang
IPC分类号： C07K16/18 , A61K31/192 , A61K9/127 , A61K9/00 , A61P25/28
摘要： The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of A plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
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公开(公告)号：US20240309077A1
公开(公告)日：2024-09-19
申请号：US18436678
申请日：2024-02-08
发明人： David Holtzman , Hong Jiang , Thu Nga Bien-Ly , Mark S. Dennis , Jing Guo , Adam P. Silverman , Ryan J. Watts , Yin Zhang
CPC分类号： C07K16/18 , A61K9/0019 , A61K9/0085 , A61K9/127 , A61K31/192 , A61P25/28 , A61K2039/505 , C07K2317/33 , C07K2317/90 , C07K2317/92
摘要： The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aβ plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
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公开(公告)号：US09834596B2
公开(公告)日：2017-12-05
申请号：US14412309
申请日：2013-07-03
发明人： David Holtzman , Hong Jiang , Marc Diamond , Najla Kfoury , Brandon Holmes
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2821
摘要： This invention relates to antibodies to tau and methods of use thereof.
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公开(公告)号：US20210284727A1
公开(公告)日：2021-09-16
申请号：US17275092
申请日：2019-09-11
发明人： David Holtzman , Jason Ulrich , Hong Jiang
IPC分类号： C07K16/28
摘要： The present disclosure encompasses anti-TREM-2 antibodies that promote TREM-2 activation and methods of using the anti-TREM-2 agonist antibodies therapeutically.
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公开(公告)号：US20220064271A1
公开(公告)日：2022-03-03
申请号：US17464190
申请日：2021-09-01
发明人： Randall Bateman , David Holtzman , Kanta Horie , Nicolas Barthelemy , Chihiro Sato , Hong Jiang
摘要： This invention relates to epitope binding agents that specifically bind to tau and methods of use thereof. The disclosure provides immunoassays, kits, and pharmaceutical compositions which include an epitope binding agent that specifically bind to tau. The disclosure provides methods of reducing the spread of tau aggregates and methods of reducing a tauopathy-related pathology.
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公开(公告)号：US20180016328A1
公开(公告)日：2018-01-18
申请号：US15548353
申请日：2016-02-04
发明人： David Holtzman , Hong Jiang , Gilbert Gallardo , Christina Ising , Cheryl Leyns
CPC分类号： C07K16/18 , A61K39/0007 , A61K48/005 , A61K2039/505 , C07K14/705 , C07K14/775 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/77 , C07K2319/00 , C07K2319/01 , C07K2319/02 , C07K2319/03 , C07K2319/06 , C07K2319/74 , C07K2319/95 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14143 , C12N2810/40
摘要： The present invention provides anti-tau constructs. Anti-tau constructs of the invention are polynucleotide sequences encoding a polypeptide comprising at least one tau binding moiety and optionally comprising a signal peptide and/or a purification moiety. The present invention also provides isolated polypeptides encoded by anti-tau constructs, vectors comprising anti-tau constructs, and isolated cells comprising said vectors.
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公开(公告)号：US20150140672A1
公开(公告)日：2015-05-21
申请号：US14523148
申请日：2014-10-24
发明人： Randall Bateman , Kwasi Mawuenyega , Vitaliy Ovod , Anna Bareiss , Tom Kasten , David Holtzman
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N33/58 , G01N33/6893 , G01N2333/4709 , G01N2458/15 , G01N2560/00 , G01N2800/2821 , G01N2800/7047
摘要： The present invention relates to methods of detecting, diagnosing, monitoring, and assessing treatment effects for Aβ amyloidosis, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms.
摘要翻译： 本发明涉及检测，诊断，监测和评估治疗效果的方法。 淀粉样变性，早期在临床疾病过程中或之前发生脑损伤和临床症状。
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公开(公告)号：US10830775B2
公开(公告)日：2020-11-10
申请号：US15515909
申请日：2015-09-30
发明人： Randall Bateman , Chihiro Sato , Kwasi Mawuenyega , Tim Miller , David Holtzman
摘要： The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.
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