公开(公告)号：US20150047441A1

公开(公告)日：2015-02-19

申请号：US14388274

申请日：2013-03-04

Applicant: Waters Technologies Corporation

Inventor： Xin Zhang ,  Pamela C. Iraneta ,  Moon Chul Jung ,  Pamela J. Longenbach ,  Frank Marszalkowski, Jr.

IPC: G01N1/30 ,  G01N1/10

CPC classification number: G01N1/30 ,  B01L3/5088 ,  B01L2300/126 ,  B01L2300/161 ,  G01N1/10 ,  G01N33/5436 ,  G01N33/96 ,  G01N2291/02466

Abstract: Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes.

Abstract translation: 描述了基于由非吸收惰性多孔材料制造的刚性亲水物体的生物样品载体。 施加到物体表面的生物流体样品被吸收到孔中，并且干燥后生物流体样品的成分保留在孔中。 与传统的干血斑（DBS）卡片冲孔不同，该物体易于处理。 与含有与碱性分析物相互作用的玻璃纤维结构的DBS卡和具有吸附纤维的其它DBS卡相反，当样品扩散通过纤维时，其具有倾向于分离血液成分的生物样品载体对药物分析物基本上是惰性的。

公开(公告)号：US09927331B2

公开(公告)日：2018-03-27

申请号：US14388274

申请日：2013-03-04

Applicant: Waters Technologies Corporation

Inventor： Xin Zhang ,  Pamela C. Iraneta ,  Moon Chul Jung ,  Pamela J. Longenbach ,  Frank Marszalkowski, Jr.

IPC: B01L3/00 ,  G01N1/30 ,  G01N33/543 ,  G01N33/96 ,  G01N1/10

CPC classification number: G01N1/30 ,  B01L3/5088 ,  B01L2300/126 ,  B01L2300/161 ,  G01N1/10 ,  G01N33/5436 ,  G01N33/96 ,  G01N2291/02466

Abstract: Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes.