公开(公告)号：US20140065651A1

公开(公告)日：2014-03-06

申请号：US14075637

申请日：2013-11-08

Applicant: Waters Technologies Corporation

Inventor： Edouard S. Bouvier ,  Bruce J. Compton ,  John C. Gebler ,  Martin Gilar ,  Ying Q. Yu ,  Peter J. Lee ,  Elizabeth K. Brown

IPC: C12Q1/37

CPC classification number: C12Q1/37 ,  C12P21/06 ,  G01N27/44726 ,  G01N27/44747 ,  G01N33/5306

Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.

Abstract translation: 本发明提供了增强具有可破坏表面活性剂的分子（例如生物分子）的化学反应的方法。 化学反应可能涉及和/或与分析有关，例如增溶，分离，纯化和/或表征分子。 在一个方面，本发明的阴离子表面活性剂可以在相对低的pH下选择性地分解。 可以相对容易地从分子/样品中除去所得表面活性剂的分解产物。 本发明适用于各种分析技术。

公开(公告)号：US09598716B2

公开(公告)日：2017-03-21

申请号：US14075637

申请日：2013-11-08

Applicant: Waters Technologies Corporation

Inventor： Edouard S. Bouvier ,  Bruce J. Compton ,  John C. Gebler ,  Martin Gilar ,  Ying Q. Yu ,  Peter J. Lee ,  Elizabeth K. Kane

IPC: C08L89/00 ,  C12N9/76 ,  C12Q1/37 ,  C12P21/06 ,  G01N27/447 ,  G01N33/53

CPC classification number: C12Q1/37 ,  C12P21/06 ,  G01N27/44726 ,  G01N27/44747 ,  G01N33/5306

Abstract: The present invention provides methods for enhancing chemical reactions of molecules, e.g., biomolecules, with destructible surfactants. The chemical reactions may involve and/or be associate with analysis, e.g., solubilizing, separating, purifying and/or characterizing the molecules. In one aspect, the anionic surfactants of the present invention may be selectively broken up at relatively low pH. The resulting breakdown products of the surfactants may be removed from the molecule/sample with relative ease. The invention has applicability in a variety of analytical techniques.