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    Oily capsule preparation and the method for preparing same
    1.
    发明授权
    Oily capsule preparation and the method for preparing same 有权

    公开(公告)号：US06627219B2

    公开(公告)日：2003-09-30

    申请号：US09896103

    申请日：2001-06-29

    申请人： Wei-Hua Hao ,  Shih Min Chen

    发明人： Wei-Hua Hao ,  Shih Min Chen

    IPC分类号： A61K948

    CPC分类号： A61K9/4891 ,  A61K9/4858 ,  A61K31/4439

    摘要： The present invention provides a oral capsule preparation, comprising a capsule prepared from a drug or the alkaline salt thereof, an oily compound or the alkaline salt thereof, an emulsifier and a polycarbon alcohol, together with an enteric coating disposed on the outer layer of the capsule; wherein said emulsifier is a composition of C6-18 organic fatty acid and an organic amine, or the mixture thereof. The invention also provides a method of preparing the oral capsule preparation of the invention.

    Controlled release carvedilol formulation
    3.
    发明授权
    Controlled release carvedilol formulation 有权
    卡维地洛控制释放制剂

    公开(公告)号：US08883207B2

    公开(公告)日：2014-11-11

    申请号：US13498751

    申请日：2010-09-29

    申请人： Wei-Hua Hao ,  Tsung-Hsin Lin ,  Ta-Chien Lu

    发明人： Wei-Hua Hao ,  Tsung-Hsin Lin ,  Ta-Chien Lu

    IPC分类号： A61K9/22 ,  A61K9/00 ,  A61K9/24 ,  A61K9/20 ,  A61K31/403

    CPC分类号： A61K9/2027 ,  A61K9/2054 ,  A61K9/209 ,  A61K31/403

    摘要： A controlled release carvedilol formulation for less frequent, preferably once daily administration is described. The controlled release formulation comprises a therapeutically effective amount of carvedilol or a pharmaceutically acceptable salt thereof, a matrix forming polymer, a solubility enhancer and a pharmaceutically acceptable carrier. In one embodiment, a controlled release formulation having a therapeutically effective amount of carvedilol is contained in two or more subunits having different release profiles. The controlled release formulation is usable in the treatment and/or prophylaxis of one or more conditions such as cardiovascular disorders.

    摘要翻译： 描述了用于较不频繁，优选每日一次施用的卡培他洛司他汀制剂。 控释制剂包含治疗有效量的卡维地洛或其药学上可接受的盐，基质形成聚合物，溶解度增强剂和药学上可接受的载体。 在一个实施方案中，具有治疗有效量的卡维地洛的控释制剂包含在具有不同释放曲线的两个或更多个亚基中。 控释制剂可用于治疗和/或预防一种或多种病症如心血管疾病。

    CONTROLLED RELEASE CARVEDILOL FORMULATION
    4.
    发明申请
    CONTROLLED RELEASE CARVEDILOL FORMULATION 有权
    控制释放卡维地洛配方

    公开(公告)号：US20120245212A1

    公开(公告)日：2012-09-27

    申请号：US13498751

    申请日：2010-09-29

    申请人： Wei-Hua Hao ,  Tsung-Hsin Lin ,  Ta-Chien Lu

    发明人： Wei-Hua Hao ,  Tsung-Hsin Lin ,  Ta-Chien Lu

    IPC分类号： A61K31/403 ,  B29C43/52

    CPC分类号： A61K9/2027 ,  A61K9/2054 ,  A61K9/209 ,  A61K31/403

    摘要： A controlled release carvedilol formulation for less frequent, preferably once daily administration is described. The controlled release formulation comprises a therapeutically effective amount of carvedilol or a pharmaceutically acceptable salt thereof, a matrix forming polymer, a solubility enhancer and a pharmaceutically acceptable carrier. In one embodiment, a controlled release formulation having a therapeutically effective amount of carvedilol is contained in two or more subunits having different release profiles. The controlled release formulation is usable in the treatment and/or prophylaxis of one or more conditions such as cardiovascular disorders.

    摘要翻译： 描述了用于较不频繁，优选每日一次施用的卡培他洛司他汀制剂。 控释制剂包含治疗有效量的卡维地洛或其药学上可接受的盐，基质形成聚合物，溶解度增强剂和药学上可接受的载体。 在一个实施方案中，具有治疗有效量的卡维地洛的控释制剂包含在具有不同释放曲线的两个或更多个亚基中。 控释制剂可用于治疗和/或预防一种或多种病症如心血管疾病。

    SELF-EMULSIFYING PHARMACEUTICAL COMPOSITIONS OF HYDROPHILIC DRUGS AND PREPARATION THEREOF
    5.
    发明申请
    SELF-EMULSIFYING PHARMACEUTICAL COMPOSITIONS OF HYDROPHILIC DRUGS AND PREPARATION THEREOF 审中-公开
    水解药物的自我发酵药物组合物及其制备方法

    公开(公告)号：US20100273730A1

    公开(公告)日：2010-10-28

    申请号：US12767293

    申请日：2010-04-26

    申请人： Chang-Shan Hsu ,  Wei-Hua Hao ,  Jong-Jing Wang ,  Tsung-Hsin Lin

    发明人： Chang-Shan Hsu ,  Wei-Hua Hao ,  Jong-Jing Wang ,  Tsung-Hsin Lin

    IPC分类号： A61K9/107 ,  A61K31/4184 ,  A61K31/7068

    CPC分类号： A61K31/4184 ,  A61K9/1075 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/7068 ,  Y02A50/465

    摘要： The present invention provides an oral self micro-emulsifying pharmaceutical composition of a hydrophilic drug or a pharmaceutically acceptable salt thereof which, in addition to the hydrophilic drug, one or more solvents for solving the hydrophilic drug to form a drug-solvent solution and a surfactant system, further comprises one or more hydrophilic carrier which are compatible with said drug-solvent solution and the surfactant system. The oral self micro-emulsifying pharmaceutical composition of the invention exhibits comparative bioavailability to that of the hydrophilic drug through injection and is stable during storage. A method for preparing the oral self micro-emulsifying pharmaceutical composition is also provided.

    摘要翻译： 本发明提供一种亲水药物或其药学上可接受的盐的口服自微乳化药物组合物，其除了亲水性药物之外，还可使用一种或多种用于溶解亲水药物以形成药物溶剂溶液和表面活性剂的溶剂 还包括与所述药物 - 溶剂溶液和表面活性剂体系相容的一种或多种亲水载体。 本发明的口服自微乳化药物组合物通过注射显示与亲水药物相比的生物利用度，并且在储存期间是稳定的。 还提供了一种制备口服自微乳化药物组合物的方法。