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    Methods for genotyping polymorphisms in humans
    3.
    发明申请
    Methods for genotyping polymorphisms in humans 失效
    人类基因分型多态性的方法

    公开(公告)号：US20060024715A1

    公开(公告)日：2006-02-02

    申请号：US11175859

    申请日：2005-07-05

    申请人： Guoying Liu ,  Simon Cawley ,  Hajime Matsuzaki ,  Earl Hubbell ,  Geoffrey Yang ,  Teresa Webster ,  Rui Mei ,  Xiaojun Di ,  Richard Chiles

    发明人： Guoying Liu ,  Simon Cawley ,  Hajime Matsuzaki ,  Earl Hubbell ,  Geoffrey Yang ,  Teresa Webster ,  Rui Mei ,  Xiaojun Di ,  Richard Chiles

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： Methods, kits and arrays of nucleic acid probes for genotyping large numbers of human SNPs in parallel are provided. A set of more than 100,000 human SNPs, known to be biallelic in at least two populations is provided. Allele specific perfect match probes and genotyping probe sets are provided for each allele of each biallelic SNP in a set of human SNPs that is useful for genetic analysis within and across populations. Probe sets that include perfect match and mismatch probes are provided. The probe sets are suitable for inclusion in an array. The invention provides the SNP and surrounding sequence and provides the sequences in such a way as to make them available for a variety of analyses including genotyping. As such, the invention relates to diverse fields impacted by the nature of genetics, including biology, medicine, and medical diagnostics.

    摘要翻译： 提供了用于并行分析大量人类SNP的核酸探针的方法，试剂盒和阵列。 提供了一组超过100,000个人类SNP，已知在至少两个人群中是双向的。 为一组人类SNP中的每个双重性SNP的每个等位基因提供等位基因特异性完全匹配探针和基因分型探针组，其可用于群体内和跨群体的遗传分析。 提供包括完美匹配和不匹配探针的探针组。 探头组适合包含在阵列中。 本发明提供了SNP和周围序列，并提供了这样的序列，使得它们可用于各种分析，包括基因分型。 因此，本发明涉及受遗传学性质影响的不同领域，包括生物学，医学和医学诊断。

    Methods for genotyping polymorphisms in humans
    4.
    发明授权
    Methods for genotyping polymorphisms in humans 失效
    人类基因分型多态性的方法

    公开(公告)号：US07361468B2

    公开(公告)日：2008-04-22

    申请号：US11175859

    申请日：2005-07-05

    申请人： Guoying Liu ,  Simon Cawley ,  Hajime Matsuzaki ,  Earl A. Hubbell ,  Geoffrey Yang ,  Teresa A. Webster ,  Rui Mei ,  Xiaojun Di ,  Richard Chiles

    发明人： Guoying Liu ,  Simon Cawley ,  Hajime Matsuzaki ,  Earl A. Hubbell ,  Geoffrey Yang ,  Teresa A. Webster ,  Rui Mei ,  Xiaojun Di ,  Richard Chiles

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12M3/00 ,  C12M1/34

    CPC分类号： C12Q1/6883 ,  C12Q2600/156

    摘要： Methods, kits and arrays of nucleic acid probes for genotyping large numbers of human SNPs in parallel are provided. A set of more than 100,000 human SNPs, known to be biallelic in at least two populations is provided. Allele specific perfect match probes and genotyping probe sets are provided for each allele of each biallelic SNP in a set of human SNPs that is useful for genetic analysis within and across populations. Probe sets that include perfect match and mismatch probes are provided. The probe sets are suitable for inclusion in an array. The invention provides the SNP and surrounding sequence and provides the sequences in such a way as to make them available for a variety of analyses including genotyping. As such, the invention relates to diverse fields impacted by the nature of genetics, including biology, medicine, and medical diagnostics.

    摘要翻译： 提供了用于并行分析大量人类SNP的核酸探针的方法，试剂盒和阵列。 提供了一组超过100,000个人类SNP，已知在至少两个人群中是双向的。 为一组人类SNP中的每个双重性SNP的每个等位基因提供等位基因特异性完全匹配探针和基因分型探针组，其可用于群体内和跨群体的遗传分析。 提供包括完美匹配和不匹配探针的探针组。 探头组适合包含在阵列中。 本发明提供了SNP和周围序列，并提供了这样的序列，使得它们可用于各种分析，包括基因分型。 因此，本发明涉及受遗传学性质影响的不同领域，包括生物学，医学和医学诊断。