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公开(公告)号：US20100311779A1
公开(公告)日：2010-12-09
申请号：US12794392
申请日：2010-06-04
申请人： Weidong ZHANG , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu , Hanxiong Li
发明人： Weidong ZHANG , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu , Hanxiong Li
IPC分类号： A61K31/4741 , C07D491/056 , A61P31/12 , A61P31/16 , A61P35/00 , A61P9/06 , A61P37/00 , A61P1/16
CPC分类号： C07D455/00 , C07D455/03
摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.
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2.发明授权Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them 失效脱氢山梨醇，脱氢卡泊肽或其组合物的制备方法，其用途和含有它们的药物组合物公开(公告)号：US07732458B2
公开(公告)日：2010-06-08
申请号：US11806874
申请日：2007-06-05
申请人： Weidong Zhang , Hanxiong Li , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu
发明人： Weidong Zhang , Hanxiong Li , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu
IPC分类号： A61K31/4738 , C07D491/02
CPC分类号： C07D455/00
摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.
摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。
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3.发明申请METHODS FOR PREPARING DEHYDROCAVIDINE, DEHYDROAPOCAVIDINE OR THEIR COMPOSITION, THEIR USE AND MEDICINAL COMPOSITON CONTAINING THEM 失效制备脱氢维生素，脱氢叶酸或其组合物的方法，其使用和含有它们的药物组合物公开(公告)号：US20100137350A9
公开(公告)日：2010-06-03
申请号：US11806874
申请日：2007-06-05
申请人： Weidong Zhang , Hanxiong Li , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu
发明人： Weidong Zhang , Hanxiong Li , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D455/00
摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.
摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。
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4.发明申请Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal compositon containing them 失效制备脱氢卡泊芬，脱氢卡泊肽或其组合物的方法，其用途和含有它们的医药组合物公开(公告)号：US20070249650A1
公开(公告)日：2007-10-25
申请号：US11806874
申请日：2007-06-05
申请人： Weidong Zhang , Hanxiong Li , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu
发明人： Weidong Zhang , Hanxiong Li , Huiliang Li , Chuan Zhang , Runhui Liu , Juan Su , Xike Xu
IPC分类号： A61K31/4741 , C07D491/02
CPC分类号： C07D455/00
摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.
摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。
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