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    Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them
    1.
    发明授权
    Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal composition containing them 失效
    脱氢山梨醇，脱氢卡泊肽或其组合物的制备方法，其用途和含有它们的药物组合物

    公开(公告)号：US07732458B2

    公开(公告)日：2010-06-08

    申请号：US11806874

    申请日：2007-06-05

    申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    IPC分类号： A61K31/4738 ,  C07D491/02

    CPC分类号： C07D455/00

    摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

    摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。

    METHODS FOR PREPARING DEHYDROCAVIDINE, DEHYDROAPOCAVIDINE OR THEIR COMPOSITION, THEIR USE AND MEDICINAL COMPOSITON CONTAINING THEM
    2.
    发明申请
    METHODS FOR PREPARING DEHYDROCAVIDINE, DEHYDROAPOCAVIDINE OR THEIR COMPOSITION, THEIR USE AND MEDICINAL COMPOSITON CONTAINING THEM 失效
    制备脱氢维生素，脱氢叶酸或其组合物的方法，其使用和含有它们的药物组合物

    公开(公告)号：US20100137350A9

    公开(公告)日：2010-06-03

    申请号：US11806874

    申请日：2007-06-05

    申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    IPC分类号： A61K31/4741 ,  C07D491/02

    CPC分类号： C07D455/00

    摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

    摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。

    Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal compositon containing them
    3.
    发明申请
    Methods for preparing dehydrocavidine, dehydroapocavidine or their composition, their use and medicinal compositon containing them 失效
    制备脱氢卡泊芬，脱氢卡泊肽或其组合物的方法，其用途和含有它们的医药组合物

    公开(公告)号：US20070249650A1

    公开(公告)日：2007-10-25

    申请号：US11806874

    申请日：2007-06-05

    申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

    IPC分类号： A61K31/4741 ,  C07D491/02

    CPC分类号： C07D455/00

    摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

    摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。

    Methods for attenuating dengue virus infection
    6.
    发明授权
    Methods for attenuating dengue virus infection 有权
    减轻登革热病毒感染的方法

    公开(公告)号：US08796235B2

    公开(公告)日：2014-08-05

    申请号：US10544146

    申请日：2004-02-23

    申请人： Shyam S. Mohapatra ,  Weidong Zhang

    发明人： Shyam S. Mohapatra ,  Weidong Zhang

    IPC分类号： C12N15/11 ,  C12N15/00 ,  C12N15/86 ,  C12N7/00 ,  A61K39/12

    CPC分类号： C12N15/111 ,  A61K48/005 ,  A61K48/0058 ,  C12N15/1131 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/30 ,  C12N2750/14143

    摘要： The present invention pertains to vectors for regulating gene expression having at least one gene expressing cassette and at least one gene suppressing cassette, wherein the gene expression cassette encodes a polypeptide of interest, and wherein the gene suppressing cassette encodes a short interfering RNA (siRNA) molecule that reduces expression of a target gene by RNA interference. The present invention further includes vectors that contain suppressor cassettes in conjunction with cassettes upregulating gene expression regulated by either a constitutive promoter, such as a general CMV promoter, or a tissue specific promoter. The present invention further includes vectors that contain Dengue virus gene suppression cassettes. The present invention further includes pharmaceutical compositions containing such vectors, methods of modulating the expression of genes in a host using such vectors, and method of producing such vectors.

    摘要翻译： 本发明涉及用于调节基因表达的载体，所述载体具有至少一个表达基因的盒和至少一个基因抑制盒，其中所述基因表达盒编码目的多肽，并且其中所述基因抑制盒编码短干扰RNA（siRNA） 通过RNA干扰降低靶基因表达的分子。 本发明还包括载体，其含有与上调由组成型启动子如一般CMV启动子或组织特异性启动子调节的基因表达的盒结合的抑制盒。 本发明还包括含有登革热病毒基因抑制盒的载体。 本发明还包括含有这些载体的药物组合物，使用这种载体调节宿主中基因表达的方法，以及生产这种载体的方法。

    Mask creation with hierarchy management using cover cells
    7.
    发明授权
    Mask creation with hierarchy management using cover cells 有权

    公开(公告)号：US07069534B2

    公开(公告)日：2006-06-27

    申请号：US10738624

    申请日：2003-12-17

    申请人： Emile Y. Sahouria ,  Weidong Zhang

    发明人： Emile Y. Sahouria ,  Weidong Zhang

    IPC分类号： G06F17/50

    CPC分类号： G06F17/5068

    摘要： A method and apparatus for translating a hierarchical IC layout file into a format that can be used by a mask writer that accepts files having a limited hierarchy. Cover cells of the original IC layout file or a modified file are designated, and the hierarchical file is redefined to include only those designated cover cells. Non-designated cover cells and other geometric data are flattened into the designated cover cells. The hierarchy of the modified file is then redefined to be less than or equal to the hierarchy limit of the mask writing tool.

    Stepless speed change bench drill
    8.
    发明授权
    Stepless speed change bench drill 失效
    无级变速台钻

    公开(公告)号：US06779952B2

    公开(公告)日：2004-08-24

    申请号：US10223314

    申请日：2002-08-19

    申请人： Weidong Zhang

    发明人： Weidong Zhang

    IPC分类号： B23G300

    CPC分类号： F16H9/18 ,  B23Q5/162 ,  F16H2009/166 ,  Y10T408/65 ,  Y10T408/67

    摘要： This invention relates to stepless speed change bench drill, comprising a pedestal, a vertical post mounted on the pedestal, a worktable and a cabinet mounted on the vertical post, a driving shaft and a main shaft mounted on the upper portion of the cabinet, a motor for transmitting power to the driving shaft, a motor movable wheel and a motor stationary wheel mounted on the driving shaft, and a main shaft movable wheel and a main shaft stationary wheel mounted on the main shaft, a speed regulation shaft provided with a threaded section and mounted between the driving shaft and the main shaft, the threaded section is engaged with a threaded hole formed on a bearing block, the bearing block is simultaneously mounted on the main shaft, the speed regulation shaft is rotated by a speed regulation hand wheel.

    摘要翻译： 本发明涉及无级变速台钻，包括基座，安装在基座上的立柱，安装在立柱上的工作台和机柜，安装在机柜上部的驱动轴和主轴， 用于将动力传递到驱动轴的马达，安装在驱动轴上的马达可动轮和马达固定轮以及安装在主轴上的主轴可动轮和主轴固定轮，设有螺纹 部分安装在驱动轴和主轴之间，螺纹部分与形成在轴承座上的螺纹孔接合，轴承座同时安装在主轴上，调速轴由调速手轮 。

    Keyboard type terminal and location method for electronic document therein
    9.
    发明授权
    Keyboard type terminal and location method for electronic document therein 有权
    键盘式终端及电子文档的位置方法

    公开(公告)号：US09448984B2

    公开(公告)日：2016-09-20

    申请号：US14234631

    申请日：2011-11-10

    申请人： Tao Xue ,  Weidong Zhang

    发明人： Tao Xue ,  Weidong Zhang

    IPC分类号： G06F17/00 ,  G06F17/22 ,  G06F15/02 ,  G06F17/21 ,  G06F3/0489

    CPC分类号： G06F17/2247 ,  G06F3/0489 ,  G06F15/0291 ,  G06F17/212

    摘要： A keyboard type terminal and a location method for electronic document therein are disclosed. The keyboard type terminal includes a setting module, a directory listing module, a detection module, a real-time directory module, a preview module and a chapter and section switchover module. The method includes: a directory listing is generated for an electronic document and the directory listing is stored; a keyboard input is detected under a reading interface of a current chapter and section of the electronic document; in response to a to-be-switched chapter and section number inputted from a user, the to-be-switched chapter and section number is immediately matched with directory entries in the stored directory listing, and the matched directory entry is displayed; a preview of a chapter and section corresponding to the to-be-switched chapter and section number is generated according to the to-be-switched chapter and section number inputted by the user, and the preview of the chapter and section is displayed to the user; and in response to a confirmation of switching to the chapter and section from the user, the previewed section is switched to. The disclosure is easy to use and implement, and improves the reading experience.

    摘要翻译： 公开了一种键盘式终端及其电子文档的定位方法。 键盘型终端包括设置模块，目录列表模块，检测模块，实时目录模块，预览模块和章节切换模块。 该方法包括：为电子文档生成目录列表，并存储目录列表; 在电子文档的当前章节和部分的阅读界面下检测到键盘输入; 响应于从用户输入的要切换的章节和段号，将被切换的章节和段号与存储的目录列表中的目录条目立即匹配，并且显示匹配的目录条目; 根据用户输入的要切换的章节号码生成与被切换的章节和段号对应的章节和部分的预览，并且将章节和部分的预览显示给 用户; 并且响应于切换到用户的章节和部分的确认，将预览部分切换到。 本公开易于使用和实现，并提高阅读体验。

    Schistosomiasis vaccine compositions and methods of use
    10.
    发明授权
    Schistosomiasis vaccine compositions and methods of use 有权
    血吸虫病疫苗组合物和使用方法

    公开(公告)号：US09248169B2

    公开(公告)日：2016-02-02

    申请号：US12821544

    申请日：2010-06-23

    申请人： Afzal A. Siddiqui ,  Gul Ahmad ,  Weidong Zhang

    发明人： Afzal A. Siddiqui ,  Gul Ahmad ,  Weidong Zhang

    IPC分类号： A61K39/00 ,  C07K14/435 ,  C12N9/64

    CPC分类号： A61K39/0003 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  C07K14/43559 ,  C12N9/6402 ,  C12Y304/22052 ,  Y02A50/423

    摘要： No effective vaccine exists for the devastating parasitic disease of Schistosomiasis. The present invention focuses on Sm-p80, a functionally important antigen of Schistosoma mansoni that plays a pivotal role in the schistosome immune evasion process. When used in a novel vaccine formulation, Sm-p80 demonstrates consistent immunogenicity, protective potential, and antifecundity effects. Two novel DNA constructs were made for immunization purposes. Sm-p80 coding sequence was cloned into VR 1020. Additionally, Sm-p80 coding sequence was cloned into pcDNA3.1 with flanking CpG motifs on each end of the Sm-p80 sequence. When used in different vaccine formulations, both of the constructs demonstrate the superior antifecundity and anti-worm effects of Sm-p80, which has great potential as an important vaccine candidate for the reduction of the morbidity associated with schistosome infection.

    摘要翻译： 没有有效的疫苗存在于血吸虫病的毁灭性寄生虫病。 本发明的重点是Sm-p80，这是在血吸虫免疫逃避过程中发挥关键作用的曼氏血吸虫的功能重要抗原。 当用于新型疫苗制剂时，Sm-p80显示出一致的免疫原性，保护性潜力和抗生殖能力的作用。 制备两种新的DNA构建体用于免疫目的。 将Sm-p80编码序列克隆到VR 1020中。另外，Sm-p80编码序列被克隆到pcDNA3.1中，并具有Sm-p80序列两端的侧翼CpG基序。 当用于不同的疫苗制剂时，这两种构建体都证明了Sm-p80具有优异的抗生殖能力和抗蠕虫作用，其作为减少与血吸虫感染相关的发病率的重要疫苗候选者具有很大的潜力。