公开(公告)号：US07732458B2

公开(公告)日：2010-06-08

申请号：US11806874

申请日：2007-06-05

申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

IPC分类号： A61K31/4738 ,  C07D491/02

CPC分类号： C07D455/00

摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。

公开(公告)号：US20100137350A9

公开(公告)日：2010-06-03

申请号：US11806874

申请日：2007-06-05

申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

IPC分类号： A61K31/4741 ,  C07D491/02

CPC分类号： C07D455/00

摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。

公开(公告)号：US20100311779A1

公开(公告)日：2010-12-09

申请号：US12794392

申请日：2010-06-04

申请人： Weidong ZHANG ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu ,  Hanxiong Li

发明人： Weidong ZHANG ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu ,  Hanxiong Li

IPC分类号： A61K31/4741 ,  C07D491/056 ,  A61P31/12 ,  A61P31/16 ,  A61P35/00 ,  A61P9/06 ,  A61P37/00 ,  A61P1/16

CPC分类号： C07D455/00 ,  C07D455/03

摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

公开(公告)号：US20070249650A1

公开(公告)日：2007-10-25

申请号：US11806874

申请日：2007-06-05

申请人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

发明人： Weidong Zhang ,  Hanxiong Li ,  Huiliang Li ,  Chuan Zhang ,  Runhui Liu ,  Juan Su ,  Xike Xu

IPC分类号： A61K31/4741 ,  C07D491/02

CPC分类号： C07D455/00

摘要： A method for preparing dehydrocavidine, dehydroapocavidine and their respective composition is provided. The composition is first prepared by isolating and purifying the quaternary ammonium alkaloid components from the medicinal plant “Yan Huang Lian” (Corydalis saxicola Bunting) through the processes of solvent extraction, water-phase organic extraction, crystallization and recrystallization, and then drying to obtain said composition containing dehydrocavidine and dehydroapocavine. When necessary, the composition or their crude extracts can be separated by chromatography to obtain dehydrocavidine or dehydroapocavidine. Dehydrocavidine, dehydroapocavidine or their respective composition can be used in manufacturing medicines for treating viral hepatitis, hepatic injury, influenza, AIDS, tumors or arrhythmia.

摘要翻译： 提供了一种制备脱氢卡泊芬，脱氢卡泊肽及其各自组成的方法。 首先通过溶剂萃取，水相有机萃取，结晶和重结晶过程从药用植物“艳黄莲”（紫堇）中分离纯化季铵生物碱成分，然后干燥得到组合物，得到 所述组合物含有脱氢加甲酸和脱氢蛋白。 必要时，可以通过色谱法分离组合物或其粗提物，得到脱氢山梨醇或脱氢卡泊芬。 脱氢卡泊芬，脱氢卡那泊或其各自的组成可用于制造用于治疗病毒性肝炎，肝损伤，流感，艾滋病，肿瘤或心律失常的药物。

公开(公告)号：US20060251708A1

公开(公告)日：2006-11-09

申请号：US10549987

申请日：2004-03-22

申请人： Jianming Chen ,  Shen Gao ,  Huiliang Li ,  Huifen Lin ,  Shaomin Wei ,  Yangmei Zhang ,  Luo Lu ,  Yangiang Zhong ,  Qing Shi ,  Yiguang Guo ,  Fei Guan ,  Wei Wang ,  Laiji Ma ,  Juan Gu

发明人： Jianming Chen ,  Shen Gao ,  Huiliang Li ,  Huifen Lin ,  Shaomin Wei ,  Yangmei Zhang ,  Luo Lu ,  Yangiang Zhong ,  Qing Shi ,  Yiguang Guo ,  Fei Guan ,  Wei Wang ,  Laiji Ma ,  Juan Gu

IPC分类号： A61K9/127 ,  A61K38/43

CPC分类号： A61K8/14 ,  A61K8/355 ,  A61K8/68 ,  A61K9/1271 ,  A61K31/122 ,  A61K31/164 ,  A61Q19/00

摘要： A coenzyme Q10 and ceramide-containing preliposome, and pharmaceutical preparations and cosmetics containing the same. The preliposome can further comprise other lipid components. A granular and lyophilized solid-preparation is produced by lyophilization or spray drying. Then, the coenzyme Q10-containing proliposome is obtained by adding water in the said solid-preparation and shaking. Transdermal absorption of coenzyme is improved together with the effect of coenzyme Q10 in cosmetics and the stability of coenzyme Q10 and liposome, which facilitate the formulation of cosmetics.

摘要翻译： 辅酶Q 10 N和含神经酰胺的前脂质体，以及含有它们的药物制剂和化妆品。 前脂质体可以进一步包含其它脂质成分。 通过冻干或喷雾干燥制备颗粒状和冻干固体制剂。 然后，通过在所述固体制剂中加水并摇动获得含辅酶Q 10的前体脂质体。 辅酶的经皮吸收与化妆品中辅酶Q 10 N的作用以及促进化妆品配方的辅酶Q 10和脂质体的稳定性一起得到改善。

公开(公告)号：US20050175681A1

公开(公告)日：2005-08-11

申请号：US10517088

申请日：2003-01-03

申请人： Jianming Chen ,  Shen Gao ,  Shaomin Wei ,  Hulfen Lin ,  Yangmei Zhang ,  Fel Guan ,  Yanqiang Zhong ,  Huiliang Li ,  Qing Shi ,  Yiguang Guo ,  Luo Lu

发明人： Jianming Chen ,  Shen Gao ,  Shaomin Wei ,  Hulfen Lin ,  Yangmei Zhang ,  Fel Guan ,  Yanqiang Zhong ,  Huiliang Li ,  Qing Shi ,  Yiguang Guo ,  Luo Lu

IPC分类号： A61K9/127 ,  A61K31/07

CPC分类号： A61K9/127

摘要： The invention relates to liposomal vitamin A and method of its preparing. The liposome containing vitamin A as active agent, carriers (supporter) and lipids as adjuvents and liposome-forming materials. The process comprises: adding vitamin A and lipids to carriers, forming a liposomal vitamin A in the form of solid, then rehydrating to give a liposomal dispersion. The process can improve the stability of vitamin A and liposomal vitamin A. The present liposome is useful for the manufacture of pharmaceutical and cosmetic formulation.

摘要翻译： 本发明涉及脂质体维生素A及其制备方法。 含有维生素A作为活性剂的脂质体，载体（载体）和脂质作为佐剂和脂质体形成材料。 该方法包括：向载体中加入维生素A和脂质，形成固体形式的脂质体维生素A，然后再水化，得到脂质体分散体。 该方法可以改善维生素A和脂质体维生素A的稳定性。本脂质体可用于制造药物和化妆品制剂。

公开(公告)号：US20060210619A1

公开(公告)日：2006-09-21

申请号：US10544088

申请日：2004-01-30

申请人： Jianming Chen ,  Luo Lu ,  Shen Gao ,  Huifen Lin ,  Shaomin Wei ,  Yangmei Zhang ,  Huiliang Li ,  Yanqiang Zhong ,  Qing Shi ,  Yiquang Guo ,  Fei Guan ,  Wei Wang ,  Laiji Ma ,  Juan Gu

发明人： Jianming Chen ,  Luo Lu ,  Shen Gao ,  Huifen Lin ,  Shaomin Wei ,  Yangmei Zhang ,  Huiliang Li ,  Yanqiang Zhong ,  Qing Shi ,  Yiquang Guo ,  Fei Guan ,  Wei Wang ,  Laiji Ma ,  Juan Gu

IPC分类号： A61K9/127 ,  A61K31/704

CPC分类号： A61K31/704 ,  A61K8/14 ,  A61K8/63 ,  A61K9/127 ,  A61Q19/00

摘要： This invention belongs to the chemical field, which is related to the fields of pharmaceutical preparations and cosmetic, especially to asiaticoside-liposome and its use for preparing pharmaceutical preparations and cosmetic. In this invention, asiaticoside and lipid components are fused by heating or dissolved in organic solvents, then treated with the rotary thin layer evaporation technique, hydrated by adding aqueous solution under shaking to afford lipid dispersing aqueous solution, and then treated by using the technics of sonication, homogeneous emulsification, microjet and extruding filtration to enwrap asiaticoside in the middle of liposomal bilayer membranes to form the hydrophilic asiaticoside-liposome. Asiaticoside-liposome of this invention can enhance the stability, skin penetrability and hydrophilicity of asiaticoside, it can be used for the preparation of cosmetic and pharmaceutical preparations especially skin-penetrated pharmaceutical preparations, and it is more convenient and easy to prepare skin-penetrated pharmaceutical preparations and cosmetic containing asiaticoside.

摘要翻译： 本发明属于化学领域，涉及药物制剂和化妆品领域，尤其涉及积雪草苷脂质体及其制备药物和化妆品的用途。 在本发明中，积雪草苷和脂质组分通过加热或溶解在有机溶剂中熔融，然后用旋转薄层蒸发技术处理，通过在振荡下加入水溶液进行水合，得到脂质分散水溶液，然后使用 超声处理，均匀乳化，微喷射和挤出过滤，在脂质体双层膜中间包裹积雪草苷，形成亲水性积雪草苷 - 脂质体。 本发明的积雪草苷 - 脂质体可以增强积雪草苷的稳定性，皮肤渗透性和亲水性，可用于制备化妆品和药物制剂，特别是皮肤渗透性药物制剂，并且更方便和容易地制备皮肤渗透的药物 含有积雪草苷的制剂和化妆品。