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公开(公告)号:US20100203041A1
公开(公告)日:2010-08-12
申请号:US12280673
申请日:2007-03-16
申请人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
发明人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
IPC分类号: A61K39/395 , C07K16/22 , C07H21/04 , A61P35/04 , A61P35/00 , A61P27/06 , A61P37/06 , A61P17/06 , A61P9/10 , C12N15/74 , C12N1/21 , C12N5/10 , C12P21/00
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/56 , C07K2317/565 , C07K2317/73
摘要: The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供抗EGFL7抗体,以及组合物和使用这些抗体的方法。
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公开(公告)号:US08398976B2
公开(公告)日:2013-03-19
申请号:US13087247
申请日:2011-04-14
申请人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
发明人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/56 , C07K2317/565 , C07K2317/73
摘要: The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供抗EGFL7抗体,以及组合物和使用这些抗体的方法。
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公开(公告)号:US20110200602A1
公开(公告)日:2011-08-18
申请号:US13087247
申请日:2011-04-14
申请人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
发明人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
IPC分类号: C07K16/22 , A61K39/395 , C12N15/13 , C12N15/85 , C12N5/07 , C12N1/00 , A61P35/04 , A61P27/00
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/56 , C07K2317/565 , C07K2317/73
摘要: The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供抗EGFL7抗体,以及组合物和使用这些抗体的方法。
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公开(公告)号:US20070031437A1
公开(公告)日:2007-02-08
申请号:US11546760
申请日:2006-10-12
申请人: Ellen Filvaroff , Weilan Ye , Leon Parker , Jo-Anne Hongo , Maike Schmidt
发明人: Ellen Filvaroff , Weilan Ye , Leon Parker , Jo-Anne Hongo , Maike Schmidt
IPC分类号: A61K39/395
CPC分类号: A61K31/7088 , A61K2039/505 , C07K16/22
摘要: The present invention provides methods of using EGFL7 antagonist to modulate vascular development. Also provided herein are methods of screening for modulators of EGFL7 activity. Furthermore, methods of treatment using EGFL7 antagonists are provided.
摘要翻译: 本发明提供使用EGFL7拮抗剂调节血管发育的方法。 本文还提供筛选EGFL7活性调节剂的方法。 此外,提供了使用EGFL7拮抗剂的治疗方法。
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公开(公告)号:US20120003208A1
公开(公告)日:2012-01-05
申请号:US12904813
申请日:2010-10-14
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: A61K31/7088 , A61K2039/505 , C07K16/22
摘要: The present invention provides methods of using EGFL7 antagonist to modulate vascular development. Also provided herein are methods of screening for modulators of EGFL7 activity. Furthermore, methods of treatment using EGFL7 antagonists are provided.
摘要翻译: 本发明提供使用EGFL7拮抗剂调节血管发育的方法。 本文还提供筛选EGFL7活性调节剂的方法。 此外,提供了使用EGFL7拮抗剂的治疗方法。
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公开(公告)号:US20090297512A1
公开(公告)日:2009-12-03
申请号:US12357819
申请日:2009-01-22
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: A61K31/7088 , A61K2039/505 , C07K16/22
摘要: The present invention provides methods of using EGFL7 antagonist to modulate vascular development. Also provided herein are methods of screening for modulators of EGFL7 activity. Furthermore, methods of treatment using EGFL7 antagonists are provided.
摘要翻译: 本发明提供使用EGFL7拮抗剂调节血管发育的方法。 本文还提供筛选EGFL7活性调节剂的方法。 此外,提供了使用EGFL7拮抗剂的治疗方法。
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公开(公告)号:US08790646B2
公开(公告)日:2014-07-29
申请号:US12904813
申请日:2010-10-14
IPC分类号: A61K39/395
CPC分类号: A61K31/7088 , A61K2039/505 , C07K16/22
摘要: The present invention provides methods of using EGFL7 antagonist to modulate vascular development. Also provided herein are methods of screening for modulators of EGFL7 activity. Furthermore, methods of treatment using EGFL7 antagonists are provided.
摘要翻译: 本发明提供使用EGFL7拮抗剂调节血管发育的方法。 本文还提供筛选EGFL7活性调节剂的方法。 此外,提供了使用EGFL7拮抗剂的治疗方法。
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公开(公告)号:US20120148572A1
公开(公告)日:2012-06-14
申请号:US13112833
申请日:2011-05-20
申请人: Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
发明人: Wei-Ching Liang , Gregory D. Plowman , Yan Wu , Weilan Ye
IPC分类号: A61K39/395 , C12N9/96 , C12N15/13 , C12N15/63 , C12N5/16 , A61P9/00 , A61P35/00 , A61P27/02 , G01N33/566 , C07K16/28 , C12P21/02
CPC分类号: C07K16/2842 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to the use of VEGF antagonists and a novel anti-α5β1 antibody for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to compositions and kits comprising novel anti-α5β1 antibodies and methods of making and using them.
摘要翻译: 本发明涉及VEGF拮抗剂和新型抗α5抗体用于治疗癌症并抑制血管生成和/或血管通透性的用途,包括抑制疾病中的异常血管生成。 本发明还涉及包含新的抗α5和bgr1抗体的组合物和试剂盒,以及制备和使用它们的方法。
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公开(公告)号:US08350010B2
公开(公告)日:2013-01-08
申请号:US13171289
申请日:2011-06-28
IPC分类号: C07K16/18
CPC分类号: A61K39/3955 , A61K45/06 , A61K51/1093 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2842 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/74
摘要: The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
摘要翻译: 本发明涉及VEGF拮抗剂和α5β1拮抗剂用于治疗癌症并抑制血管生成和/或血管通透性的用途,包括抑制疾病中的异常血管发生。 本发明还涉及VEGFR激动剂和α5β1激动剂促进血管生成和血管通透性的用途。 本发明还涉及新的抗α5β1抗体,包含它们的组合物和试剂盒以及制备和使用它们的方法。
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公开(公告)号:US20120195908A1
公开(公告)日:2012-08-02
申请号:US13171289
申请日:2011-06-28
IPC分类号: A61K39/395 , A61P7/00 , C12N9/96 , C07K16/28
CPC分类号: A61K39/3955 , A61K45/06 , A61K51/1093 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K16/2842 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/74
摘要: The present invention relates to the use of VEGF antagonists and alpha5beta1 antagonists for treating cancer and inhibiting angiogenesis and/or vascular permeability, including inhibiting abnormal angiogenesis in diseases. The present invention also relates to use of a VEGFR agonists and alpha5beta1 agonists to promote angiogenesis and vascular permeability. The present invention also relates to new anti-alpha5beta1 antibodies, compositions and kits comprising them and methods of making and using them.
摘要翻译: 本发明涉及VEGF拮抗剂和α5β1拮抗剂用于治疗癌症并抑制血管生成和/或血管通透性的用途,包括抑制疾病中的异常血管发生。 本发明还涉及VEGFR激动剂和α5β1激动剂促进血管生成和血管通透性的用途。 本发明还涉及新的抗α5β1抗体,包含它们的组合物和试剂盒以及制备和使用它们的方法。
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