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公开(公告)号:US20070031437A1
公开(公告)日:2007-02-08
申请号:US11546760
申请日:2006-10-12
申请人: Ellen Filvaroff , Weilan Ye , Leon Parker , Jo-Anne Hongo , Maike Schmidt
发明人: Ellen Filvaroff , Weilan Ye , Leon Parker , Jo-Anne Hongo , Maike Schmidt
IPC分类号: A61K39/395
CPC分类号: A61K31/7088 , A61K2039/505 , C07K16/22
摘要: The present invention provides methods of using EGFL7 antagonist to modulate vascular development. Also provided herein are methods of screening for modulators of EGFL7 activity. Furthermore, methods of treatment using EGFL7 antagonists are provided.
摘要翻译: 本发明提供使用EGFL7拮抗剂调节血管发育的方法。 本文还提供筛选EGFL7活性调节剂的方法。 此外,提供了使用EGFL7拮抗剂的治疗方法。
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公开(公告)号:US20100203041A1
公开(公告)日:2010-08-12
申请号:US12280673
申请日:2007-03-16
申请人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
发明人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
IPC分类号: A61K39/395 , C07K16/22 , C07H21/04 , A61P35/04 , A61P35/00 , A61P27/06 , A61P37/06 , A61P17/06 , A61P9/10 , C12N15/74 , C12N1/21 , C12N5/10 , C12P21/00
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/56 , C07K2317/565 , C07K2317/73
摘要: The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供抗EGFL7抗体,以及组合物和使用这些抗体的方法。
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公开(公告)号:US08398976B2
公开(公告)日:2013-03-19
申请号:US13087247
申请日:2011-04-14
申请人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
发明人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
IPC分类号: A61K39/395
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/56 , C07K2317/565 , C07K2317/73
摘要: The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供抗EGFL7抗体,以及组合物和使用这些抗体的方法。
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公开(公告)号:US20110200602A1
公开(公告)日:2011-08-18
申请号:US13087247
申请日:2011-04-14
申请人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
发明人: Weilan Ye , Maike Schmidt , Jo-Anne Hongo , Yan Wu
IPC分类号: C07K16/22 , A61K39/395 , C12N15/13 , C12N15/85 , C12N5/07 , C12N1/00 , A61P35/04 , A61P27/00
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/56 , C07K2317/565 , C07K2317/73
摘要: The invention provides anti-EGFL7 antibodies, and compositions comprising and methods of using these antibodies.
摘要翻译: 本发明提供抗EGFL7抗体,以及组合物和使用这些抗体的方法。
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公开(公告)号:US08466260B2
公开(公告)日:2013-06-18
申请号:US12751819
申请日:2010-03-31
申请人: Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
发明人: Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
IPC分类号: C12P21/08
CPC分类号: G01N33/6854 , A61K31/138 , A61K31/4196 , A61K31/454 , A61K31/4745 , A61K31/517 , A61K31/56 , A61K31/568 , A61K31/5685 , A61K31/69 , A61K33/24 , A61K38/19 , A61K39/0011 , A61K39/39533 , A61K39/39558 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/283 , C07K2317/24 , C07K2317/522 , C07K2317/73 , G01N33/574 , G01N33/6857 , Y02A50/473
摘要: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号:US08362213B2
公开(公告)日:2013-01-29
申请号:US12751791
申请日:2010-03-31
申请人: Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
发明人: Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
CPC分类号: A61K39/3955 , A61K31/69 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/283 , C07K2317/24 , C07K2317/92 , A61K2300/00
摘要: Anti-FcRH5 antibodies and immunoconjugates thereof are provided. Methods of using anti-FcRH5 antibodies and immunoconjugates thereof are provided.
摘要翻译: 提供抗FcRH5抗体及其免疫偶联物。 提供使用抗FcRH5抗体及其免疫偶联物的方法。
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7.Methods for treating neuropathy by agonist anti-trk-C monoclonal antibodies 有权
标题翻译: 通过激动剂抗-trk-C单克隆抗体治疗神经病变的方法公开(公告)号:US07615383B2
公开(公告)日:2009-11-10
申请号:US11581865
申请日:2006-10-16
IPC分类号: G01N33/53 , A61K39/395 , A61K39/00
CPC分类号: C07K16/32 , A61K2039/505 , C07K16/2863 , C07K2317/21 , C07K2317/34
摘要: The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, including nerve cell damage associated with acute nervous cell system injury and chronic neurodegenerative diseases, including peripheral neuropathy.
摘要翻译: 本发明涉及模拟NT-3(trkC的天然配体)的某些生物学活性的激动剂抗-trkC单克隆抗体。 本发明还涉及这种抗体在预防和/或治疗细胞变性中的用途,包括与急性神经细胞系统损伤和慢性神经变性疾病(包括周围神经病变)相关的神经细胞损伤。
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公开(公告)号:US07982015B2
公开(公告)日:2011-07-19
申请号:US11120399
申请日:2005-05-02
IPC分类号: C07K16/18
CPC分类号: C07K14/47 , A61K2039/505 , C07K14/4748 , C07K16/30 , C07K2317/34 , G01N33/57415 , G01N33/57484
摘要: The present invention concerns compositions and methods for the treatment of disorders characterized by the overexpression of an LIV-1. More specifically, the compositions include DNA and amino acid sequences of an LIV-1, antibodies to an LIV-1, and methods for the treatment of a mammal susceptible to or diagnosed with cancer wherein an LIV-1 is overexpressed.
摘要翻译: 本发明涉及用于治疗特征在于LIV-1过表达的疾病的组合物和方法。 更具体地,组合物包括LIV-1的DNA和氨基酸序列,LIV-1的抗体,以及用于治疗敏感或诊断为癌症的哺乳动物的方法,其中LIV-1被过表达。
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9.
公开(公告)号:US20110171125A1
公开(公告)日:2011-07-14
申请号:US12751791
申请日:2010-03-31
申请人: Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
发明人: Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
IPC分类号: A61K51/10 , C07K16/32 , C07K16/00 , C12N9/96 , A61K39/395 , C12N5/071 , C12N5/0781 , G01N33/53 , A61P31/00 , A61P35/00
CPC分类号: A61K39/3955 , A61K31/69 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/283 , C07K2317/24 , C07K2317/92 , A61K2300/00
摘要: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译: 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物,以及使用这些物质组合物的方法。
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公开(公告)号:US07858330B2
公开(公告)日:2010-12-28
申请号:US11418347
申请日:2006-05-04
申请人: Jo-Anne Hongo , Wesley Chang , Frederic J. de Sauvage , Dan L. Eaton , Allen J. Ebens, Jr. , Gretchen D. Frantz , Hartmut Koeppen , Andrew Polson , Victoria Smith
发明人: Jo-Anne Hongo , Wesley Chang , Frederic J. de Sauvage , Dan L. Eaton , Allen J. Ebens, Jr. , Gretchen D. Frantz , Hartmut Koeppen , Andrew Polson , Victoria Smith
IPC分类号: G01N33/574
CPC分类号: C07K16/3061
摘要: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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