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    Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
    10.
    发明授权
    Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis 有权
    具有集成流体容纳结构的光子晶体传感器，结合其的样品处理装置及其用于生物分子相互作用分析的用途

    公开(公告)号：US07968836B2

    公开(公告)日：2011-06-28

    申请号：US12800082

    申请日：2010-05-06

    申请人： Brian T. Cunningham ,  Charles Choi

    发明人： Brian T. Cunningham ,  Charles Choi

    IPC分类号： H01L31/00

    CPC分类号： G01N21/4133 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/5085 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  B82Y20/00 ,  G01N21/253 ,  G01N21/7743 ,  G02B2006/1213

    摘要： Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. The PC sensors are further integrated into a sample handling device such as a microwell plate. Sensors and sensing systems of the present disclosure are capable of high throughput sensing of analytes in fluid samples, bulk refractive index detection, and label-free detection of a range of molecules, including biomolecules and therapeutic candidates. The present disclosure also provides a commercially attractive fabrication platform for making photonic crystal sensors and systems wherein an integrated fluid containment structure and a photonic crystal structure are fabricated in a single molding or imprinting processing step amendable to high throughput processing.

    摘要翻译： 描述了具有集成流体容纳和/或流体处理结构的光子晶体（PC）传感器以及包含PC传感器的传感器阵列和感测系统。 PC传感器进一步集成到诸如微孔板之类的样品处理装置中。 本公开的传感器和感测系统能够高流量感测流体样品中的分析物，体积折射率检测和一系列分子（包括生物分子和治疗候选物）的无标记检测。 本公开还提供了用于制造光子晶体传感器和系统的商业上有吸引力的制造平台，其中集成流体容纳结构和光子晶体结构在可修改为高通量处理的单个模制或压印处理步骤中制造。