公开(公告)号：US20100160660A1

公开(公告)日：2010-06-24

申请号：US12449638

申请日：2008-02-15

申请人： Weiping Chen ,  Felix Spindler ,  Ulrike Nettekoven ,  Benoît Pugin

发明人： Weiping Chen ,  Felix Spindler ,  Ulrike Nettekoven ,  Benoît Pugin

IPC分类号： C07C51/36 ,  C07F19/00 ,  C07C231/12

CPC分类号： C07C51/36 ,  B01J2231/645 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07F17/02 ,  C07C59/64 ,  C07C59/68 ,  C07C57/30

摘要： Abstract Compounds of the formula (I) in the form of racemates, enantiomerically pure diastereomers or a mixture of diastereomers, where the radicals R1 are identical or different and are each C1-C4-alkyl; m is 0 or an integer from 1 to 4; n is 0 or an integer from 1 to 3; p is 0 or an integer from 1 to 5; R2 is an aromatic hydrocarbon radical or a C-bonded heterohydrocarbon radical and R3 is an aliphatic or C-bonded heteroaliphatic hydrocarbon radical; R2 and R3 are identical or different and are each an aliphatic or C-bonded heteroaliphatic hydrocarbon radical; R4 is an unsubstituted or C1-C6-alkyl-, C1-C6-alkoxy- or halogen-substituted hydrocarbon radical; and A is a secondary amino group, are ligands for metal complexes which are suitable as catalysts for homogeneous enantioselective hydrogenation.

摘要翻译： 摘要式（I）化合物为外消旋体，对映体纯的非对映体或非对映异构体的混合物，其中基团R 1相同或不同并且各自为C 1 -C 4 - 烷基; m为0或1〜4的整数; n为0或1〜3的整数; p为0或1至5的整数; R2是芳族烃基或C键合的杂烃基，R3是脂族或C键合的杂脂族烃基; R2和R3相同或不同，各自为脂族或C键合的杂脂族烃基; R4是未取代的或C1-C6-烷基 - ，C1-C6-烷氧基或卤素取代的烃基; 并且A是仲氨基，是金属络合物的配体，其适合作为均相对映选择性氢化的催化剂。

公开(公告)号：US07977499B2

公开(公告)日：2011-07-12

申请号：US12449638

申请日：2008-02-15

申请人： Weiping Chen ,  Felix Spiindler ,  Ulrike Nettekoven ,  Benoît Pugin

发明人： Weiping Chen ,  Felix Spiindler ,  Ulrike Nettekoven ,  Benoît Pugin

IPC分类号： C07F15/00 ,  C07C57/30

CPC分类号： C07C51/36 ,  B01J2231/645 ,  B01J2531/16 ,  B01J2531/17 ,  B01J2531/18 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07F17/02 ,  C07C59/64 ,  C07C59/68 ,  C07C57/30

摘要： Abstract Compounds of the formula (I) in the form of racemates, enantiomerically pure diastereomers or a mixture of diastereomers, where the radicals R1 are identical or different and are each C1-C4-alkyl; m is 0 or an integer from 1 to 4; n is 0 or an integer from 1 to 3; p is 0 or an integer from 1 to 5; R2 is an aromatic hydrocarbon radical or a C-bonded heterohydrocarbon radical and R3 is an aliphatic or C-bonded heteroaliphatic hydrocarbon radical; R2 and R3 are identical or different and are each an aliphatic or C-bonded heteroaliphatic hydrocarbon radical; R4 is an unsubstituted or C1-C6-alkyl-, C1-C6-alkoxy- or halogen-substituted hydrocarbon radical; and A is a secondary amino group, are ligands for metal complexes which are suitable as catalysts for homogeneous enantioselective hydrogenation.

摘要翻译： 摘要式（I）化合物为外消旋体，对映体纯的非对映体或非对映异构体的混合物，其中基团R 1相同或不同并且各自为C 1 -C 4 - 烷基; m为0或1〜4的整数; n为0或1〜3的整数; p为0或1至5的整数; R2是芳族烃基或C键合的杂烃基，R3是脂族或C键合的杂脂族烃基; R2和R3相同或不同，各自为脂族或C键合的杂脂族烃基; R4是未取代的或C1-C6-烷基 - ，C1-C6-烷氧基或卤素取代的烃基; 并且A是仲氨基，是金属络合物的配体，其适合作为均相对映选择性氢化的催化剂。

公开(公告)号：US08106227B2

公开(公告)日：2012-01-31

申请号：US12226213

申请日：2007-04-11

申请人： Weiping Chen ,  Felix Spindler ,  Benoît Pugin

发明人： Weiping Chen ,  Felix Spindler ,  Benoît Pugin

IPC分类号： C07F15/02

CPC分类号： C07F17/02 ,  C07B53/00 ,  C07F9/52

摘要： Compounds of the formula I in the form of enantiomerically pure diastereomers or a mixture of diastereomers, (I), where the radicals R1 are identical or different and are each C1-C4-alkyl; m is 0 or an integer from 1 to 3; n is 0 or an integer from 1 to 4; R2 is a hydrocarbon radical or a C-bonded heterohydrocarbon radical; Cp is unsubstituted or C1-C4-alkyl-substituted cyclopentadienyl; Y is a C-bonded chiral group which directs metals of metallation reagents into the ortho position; and Phos is a P-bonded P(III) substituent. The compounds are chiral ligands for complexes of transition metals which are used as homogeneous catalysts in asymmetric syntheses.

摘要翻译： 式I化合物为对映体纯的非对映体形式或非对映异构体（I）的混合物，其中基团R 1相同或不同并且各自为C 1 -C 4 - 烷基; m为0或1〜3的整数; n为0或1至4的整数; R2是烃基或C键合的杂烃基; Cp是未取代的或C 1 -C 4烷基取代的环戊二烯基; Y是将金属化试剂的金属引导到邻位的C-键合手性基团; Phos是P键合的P（III）取代基。 这些化合物是用于不对称合成中的均相催化剂的过渡金属络合物的手性配体。

公开(公告)号：US20090124812A1

公开(公告)日：2009-05-14

申请号：US12226213

申请日：2007-04-11

申请人： Weiping Chen ,  Felix Spindler ,  Benoit Pugin

发明人： Weiping Chen ,  Felix Spindler ,  Benoit Pugin

IPC分类号： C07F15/02

CPC分类号： C07F17/02 ,  C07B53/00 ,  C07F9/52

摘要： Compounds of the formula I in the form of enantiomerically pure diastereomers or a mixture of diastereomers, (I), where the radicals R1 are identical or different and are each C1-C4-alkyl; m is 0 or an integer from 1 to 3; n is 0 or an integer from 1 to 4; R2 is a hydrocarbon radical or a C-bonded heterohydrocarbon radical; Cp is unsubstituted or C1-C4-alkyl-substituted cyclopentadienyl; Y is a C-bonded chiral group which directs metals of metallation reagents into the ortho position; and Phos is a P-bonded P(III) substituent. The compounds are chiral ligands for complexes of transition metals which are used as homogeneous catalysts in asymmetric syntheses.

摘要翻译： 式I化合物为对映体纯的非对映体形式或非对映异构体（I）的混合物，其中基团R 1相同或不同并且各自为C 1 -C 4 - 烷基; m为0或1〜3的整数; n为0或1至4的整数; R2是烃基或C键合的杂烃基; Cp是未取代的或C 1 -C 4烷基取代的环戊二烯基; Y是将金属化试剂的金属引导到邻位的C-键合手性基团; Phos是P键合的P（III）取代基。 这些化合物是用于不对称合成中的均相催化剂的过渡金属络合物的手性配体。

公开(公告)号：US20110241345A1

公开(公告)日：2011-10-06

申请号：US13061707

申请日：2008-09-09

申请人： Weiping Chen

发明人： Weiping Chen

IPC分类号： H02K7/18 ,  F03B17/04

CPC分类号： E02B9/00 ,  F03B17/005 ,  F05B2240/40 ,  Y02E10/22

摘要： An expandable multi-set circulation hydroelectric power generation method and system. The system includes a power station control area (A), a transformer substation area (B), a circulation cistern (C) provided with a plurality of small cisterns (CA1 to CA20). Gates (E1 to E20) and protection screenings are installed in the small cisterns (CA1 to CA20). A water pump set station area is provided with a plurality of water pump sets (D1 to D20). The water pump sets (D1 to D20) are connected to the small cisterns (CA1 to CA20). The small cisterns (CA1 to CA20) are connected to pressure pipes (G1 to G20). The pressure pipes (G1 to G20) are connected to work done pipes (H1 to H10). A plurality of water turbine generator sets (F1 to F51) and a plurality of gates (E42, E43, E47, E50, E53, E56, E59, E63, E64, E65) are installed in the work done pipes (H1 to H10).

摘要翻译： 一种可扩展的多集循环水电发电方法及系统。 该系统包括电站控制区域（A），变电站区域（B），设有多个小水箱（CA1至CA20）的循环水箱（C）。 门（E1至E20）和保护屏蔽安装在小水箱（CA1至CA20）中。 水泵设置站区域设置有多个水泵组（D1〜D20）。 水泵组（D1〜D20）与小水箱（CA1〜CA20）连接。 小水箱（CA1至CA20）连接到压力管（G1至G20）。 压力管道（G1至G20）连接工作管道（H1至H10）。 在工作完成的管道（H1至H10）中安装有多个水轮发电机组（F1至F51）和多个门（E42，E43，E47，E50，E53，E56，E59，E63，E64，E65） 。

公开(公告)号：US20090270499A1

公开(公告)日：2009-10-29

申请号：US12109249

申请日：2008-04-24

申请人： Weiping Chen

发明人： Weiping Chen

IPC分类号： A61K31/336 ,  C07D213/55 ,  C07D301/02 ,  C07C211/00 ,  A61P31/18 ,  C07C269/00 ,  C07D303/02 ,  A61K31/27

CPC分类号： C07C209/62 ,  C07C271/22 ,  C07D213/53 ,  C07D213/56 ,  C07C211/27

摘要： This invention relates to a process for synthesizing Atazanvir, including novel intermediates and novel steps to various intermediates along the synthetic pathway.

摘要翻译： 本发明涉及一种合成阿扎那韦的方法，包括新型中间体和沿合成途径向不同中间体的新步骤。

公开(公告)号：US20060135355A1

公开(公告)日：2006-06-22

申请号：US10524550

申请日：2003-07-30

申请人： William Hems ,  Weiping Chen ,  Jianliang Xiao

发明人： William Hems ,  Weiping Chen ,  Jianliang Xiao

IPC分类号： B01J31/00

CPC分类号： C07C247/10 ,  B01J31/1616 ,  B01J31/1625 ,  B01J31/165 ,  B01J31/1658 ,  B01J31/1683 ,  B01J31/1805 ,  B01J2231/32 ,  B01J2231/326 ,  B01J2231/4211 ,  B01J2231/4261 ,  B01J2231/48 ,  B01J2231/50 ,  B01J2231/641 ,  B01J2231/643 ,  B01J2231/72 ,  B01J2231/74 ,  B01J2531/821 ,  B01J2531/824 ,  B01J2531/828 ,  C07B2200/07 ,  C07B2200/11 ,  C07C29/145 ,  C07C211/27 ,  C07C211/29 ,  C07C217/60 ,  C07C217/64 ,  C07C33/46

摘要： An immobilised nitrogen-containing ligand is described comprising the reaction product of a compound of formula (I) wherein R5, R6, R7 and R8 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group, an aryl group, a urethane group, a sulphonyl group or form an imine group, R1, R2, R3, and R4 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group or an aryl group and at least one of R1, R2, R3 and R4 is functionalised with a functional group, and a solid support having a site capable of reacting with said functional group. The nitrogen-containing ligand is useful for preparing immobilised catalysts for performing e.g. asymmetric catalysis.

摘要翻译： 描述了一种固定化含氮配体，其包括式（I）化合物的反应产物，其中R 5，R 6，R 7，R 7， R 8独立地是氢，饱和或不饱和的C 1 -C 10烷基，芳基，氨基甲酸酯基，磺酰基或亚胺基，R 1， R 2，R 3和R 4独立地是氢，饱和或不饱和的C 1 -C 10烷基或芳基，并且在 R 1，R 2，R 3和R 4中的至少一个用官能团官能化，并且 具有能够与所述官能团反应的位置的固体支持体。 含氮配体可用于制备固定催化剂，用于进行例如 不对称催化。

公开(公告)号：US20100168422A1

公开(公告)日：2010-07-01

申请号：US12345838

申请日：2008-12-30

申请人： Weiping Chen

发明人： Weiping Chen

IPC分类号： C07D413/14 ,  C07D493/04 ,  C07D307/32 ,  C07D265/30 ,  C07C291/04 ,  C07D417/14 ,  C07F9/655

CPC分类号： C07D295/088 ,  C07C239/12 ,  C07D307/33 ,  C07D493/04 ,  C07F9/4006 ,  C07F9/6561

摘要： Provided herein are compounds and methods useful for preparing hexahydrofuro[2,3-b]furan-3-ol. Hexahydrofuro[2,3-b]furan-3-ol can be efficiently synthesized in four steps from readily available starting materials.

摘要翻译： 本文提供了可用于制备六氢呋喃并[2,3-b]呋喃-3-醇的化合物和方法。 六氢呋喃并[2,3-b]呋喃-3-醇可以从容易获得的起始原料四步高效地合成。