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公开(公告)号：US08025901B2
公开(公告)日：2011-09-27
申请号：US12615859
申请日：2009-11-10
申请人： Weiyuan John Kao , Jing Li , David Lok , Rathna Gundloori
发明人： Weiyuan John Kao , Jing Li , David Lok , Rathna Gundloori
IPC分类号： A61K35/00 , A61K9/10 , A61K47/48 , C08G81/00 , C08L101/00 , C08L101/14
CPC分类号： C08L101/14 , A61K47/60 , A61K47/6903 , A61L15/225 , A61L15/32 , A61L15/325 , A61L15/60 , C08G81/00 , Y10S530/815 , Y10S530/817 , C08L89/06
摘要： Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.
摘要翻译： 公开了水凝胶，其中将聚合物基体改性为含有共价键合到聚合物基质上的双官能聚（亚烷基二醇）分子。 水凝胶可以使用例如戊二醛进行交联。 水凝胶也可以通过可光聚合的丙烯酸酯的互穿网络交联。 水凝胶也可以被修饰成具有共价键合到聚（亚烷基二醇）分子或夹带在水凝胶内的药理活性剂。 活细胞也可能被夹带在水凝胶内。
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公开(公告)号：US20100209509A1
公开(公告)日：2010-08-19
申请号：US12615859
申请日：2009-11-10
申请人： Weiyuan John Kao , Jing Li , David Lok , Rathna Gundloori
发明人： Weiyuan John Kao , Jing Li , David Lok , Rathna Gundloori
CPC分类号： C08L101/14 , A61K47/60 , A61K47/6903 , A61L15/225 , A61L15/32 , A61L15/325 , A61L15/60 , C08G81/00 , Y10S530/815 , Y10S530/817 , C08L89/06
摘要： Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.
摘要翻译： 公开了水凝胶，其中将聚合物基体改性为含有共价键合到聚合物基质上的双官能聚（亚烷基二醇）分子。 水凝胶可以使用例如戊二醛进行交联。 水凝胶也可以通过可光聚合的丙烯酸酯的互穿网络交联。 水凝胶也可以被修饰成具有共价键合到聚（亚烷基二醇）分子或夹带在水凝胶内的药理活性剂。 活细胞也可能被夹带在水凝胶内。
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公开(公告)号：US20050276858A1
公开(公告)日：2005-12-15
申请号：US11093531
申请日：2005-03-30
申请人： Weiyuan Kao , Jeffrey Phillips , Jing Li , David Lok , Rathna Gundloori
发明人： Weiyuan Kao , Jeffrey Phillips , Jing Li , David Lok , Rathna Gundloori
CPC分类号： C08L101/14 , A61K47/60 , A61K47/6903 , A61L15/225 , A61L15/32 , A61L15/325 , A61L15/60 , C08G81/00 , C08L89/06
摘要： Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.
摘要翻译： 公开了水凝胶，其中将聚合物基体改性为含有共价键合到聚合物基质上的双官能聚（亚烷基二醇）分子。 水凝胶可以使用例如戊二醛进行交联。 水凝胶也可以通过可光聚合的丙烯酸酯的互穿网络交联。 水凝胶也可以被修饰成具有共价键合到聚（亚烷基二醇）分子或夹带在水凝胶内的药理活性剂。 活细胞也可能被夹带在水凝胶内。
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公开(公告)号：US07615593B2
公开(公告)日：2009-11-10
申请号：US10128198
申请日：2002-04-23
申请人： Weiyun John Kao , Jing Li , David Lok , Rathna Gundloori
发明人： Weiyun John Kao , Jing Li , David Lok , Rathna Gundloori
CPC分类号： C08L101/14 , A61K47/60 , A61K47/6903 , A61L15/225 , A61L15/32 , A61L15/325 , A61L15/60 , C08G81/00 , Y10S530/815 , Y10S530/817 , C08L89/06
摘要： Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.
摘要翻译： 公开了水凝胶，其中将聚合物基体改性为含有共价键合到聚合物基质上的双官能聚（亚烷基二醇）分子。 水凝胶可以使用例如戊二醛进行交联。 水凝胶也可以通过可光聚合的丙烯酸酯的互穿网络交联。 水凝胶也可以被修饰成具有共价键合到聚（亚烷基二醇）分子或夹带在水凝胶内的药理活性剂。 活细胞也可能被夹带在水凝胶内。
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公开(公告)号：US20060100369A1
公开(公告)日：2006-05-11
申请号：US11273393
申请日：2005-11-14
申请人： Weiyuan Kao , Jing Li , David Lok , Rathna Gundloori
发明人： Weiyuan Kao , Jing Li , David Lok , Rathna Gundloori
IPC分类号： A61K47/48
CPC分类号： C08L101/14 , A61K47/60 , A61K47/6903 , A61L15/225 , A61L15/32 , A61L15/325 , A61L15/60 , C08G81/00 , Y10S530/815 , Y10S530/817 , C08L89/06
摘要： Disclosed are hydrogels wherein a polymer matrix is modified to contain a bifunctional poly(alkylene glycol) molecule covalently bonded to the polymer matrix. The hydrogels can be cross-linked using, for example, glutaraldehyde. The hydrogels may also be crosslinked via an interpenetrating network of a photopolymerizable acrylates. The hydrogels may also be modified to have pharmacologically-active agents covalently bonded to the poly(alkylene glycol) molecules or entrained within the hydrogel. Living cells may also be entrained within the hydrogels.
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