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1.发明授权Schisandrae fructus extracts for inhibition or prevention of H1N1 influenza virus infection and its application thereof 有权五味子提取物用于抑制或预防H1N1流感病毒感染及其应用公开(公告)号：US08414938B2
公开(公告)日：2013-04-09
申请号：US13298607
申请日：2011-11-17
申请人： Wen-Liang Chang , Chen-Wen Yao , Chi-Hong Chu , An-Rong Lee , Ann Chen , Wen-Hsin Huang , Kuo-Yuan Hwa , Chiao-Ying Chien , Chien-Yi Pai
发明人： Wen-Liang Chang , Chen-Wen Yao , Chi-Hong Chu , An-Rong Lee , Ann Chen , Wen-Hsin Huang , Kuo-Yuan Hwa , Chiao-Ying Chien , Chien-Yi Pai
IPC分类号： A01N65/00
CPC分类号： A61K36/79 , A61K31/122 , A61K31/357 , A61K2236/35
摘要： Disclosed are an Schisandrae fructus extract for inhibition or prevention of influenza and its application, wherein the Schisandrae fructus extract is obtained by water, methanol, or ethanol extraction process and the extract comprises compounds such as schisandrone, benzoylgomisin P, wulignan A1, epigomisin O, epiwulignan A1, and tigloylgomisin P. The extracts and purified compounds of Schisandrae fructus has anti-influenza virus H1N1 and H1N1-TR (a Tamiflu drug resistant virus strain) activities, therefore the extracts and the purified compounds of Schisandrae fructus can be applied as an inhitibory agent of a pharmaceutical composition for treatment or prevention agent for influenza infection.
摘要翻译： 公开了用于抑制或预防流感及其应用的五味子提取物，其中五味子提取物通过水，甲醇或乙醇提取方法获得，并且提取物包含化合物，例如五味子酮，苯甲酰基乳球菌素P，五味子胺A1，表不见素O， 五味子甙A和枸橼酸甘草聚糖P.提取物和纯化的五味子化合物具有抗流感病毒H1N1和H1N1-TR（达菲药物耐药病毒株）的活性，因此提取物和五味子的纯化化合物可以作为 用于流感感染的治疗或预防剂的药物组合物的生物剂。
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2.发明申请Herbal Extract Having Anti- Influenza Virus Activity and Preparation of Same 审中-公开草药提取物具有抗流感病毒的活性及其制备方法公开(公告)号：US20080152735A1
公开(公告)日：2008-06-26
申请号：US11963628
申请日：2007-12-21
申请人： Wen-Liang Chang , Chen-Wen Yao , Ann Chen , Chung-Yang Yen , Li-Shian Shi , Jenn-Han Chen , Ching-Len Liao , Kuo-Yuan Hwa , An-Rong Lee , Po-Huang Liang
发明人： Wen-Liang Chang , Chen-Wen Yao , Ann Chen , Chung-Yang Yen , Li-Shian Shi , Jenn-Han Chen , Ching-Len Liao , Kuo-Yuan Hwa , An-Rong Lee , Po-Huang Liang
IPC分类号： A61K36/236 , A61K36/00 , A61K36/489 , A61K31/352 , A61P31/12
CPC分类号： A61K36/484 , A61K31/352 , A61K36/236 , A61K36/489
摘要： The invention provides a herbal extract having anti-influenza virus activity, by extracting Sophora flavescens Ait, Thesium chinense Turcz, licorice, or mixture thereof with solvent. The herbal extract contains at least one compound selected from the group of compounds represented by following formula (I) or (II) or mixture thereof:
摘要翻译： 本发明提供了具有抗流感病毒活性的草药提取物，通过提取苦参，枸杞，甘草或其与溶剂的混合物。 草药提取物含有至少一种选自由下式（I）或（II）表示的化合物或其混合物的化合物：
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公开(公告)号：US20070154897A1
公开(公告)日：2007-07-05
申请号：US11407101
申请日：2006-04-20
申请人： Chung-Yang Yen , Ching-Len Liao , Jenn-Han Chen , Wen-Liang Chang , Ann Chen , Kuo-Yuan Hwa , Chen-Wen Yao , Chao-Wen Cheng , Shun-Min Yang
发明人： Chung-Yang Yen , Ching-Len Liao , Jenn-Han Chen , Wen-Liang Chang , Ann Chen , Kuo-Yuan Hwa , Chen-Wen Yao , Chao-Wen Cheng , Shun-Min Yang
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
摘要翻译： 本发明提供了用于检测肾病的生物标志物，其选自寡核苷酸序列，互补序列或衍生物，氨基酸序列或衍生物，片段，变体，膜联蛋白A2或S100A6的抗体或其组合。 此外，本发明还提供了用于肾脏疾病检测的测定试剂盒和方法，实际上用于由急性肾小管坏死引起的肾脏疾病。
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公开(公告)号：US20070254290A1
公开(公告)日：2007-11-01
申请号：US11594153
申请日：2006-11-08
申请人： Chung-Yang Yen , Ann Chen , Ching-Len Liao , Jenn-Han Chen , Wen-Liang Chang , Chen-Wen Yao , Kuo-Yuan Hwa
发明人： Chung-Yang Yen , Ann Chen , Ching-Len Liao , Jenn-Han Chen , Wen-Liang Chang , Chen-Wen Yao , Kuo-Yuan Hwa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： This invention discloses a method for diagnosing Crescentic glomerulonephritis (CRGN) using at least a sample from a patient. The method is to find a least one biomarker for diagnosing Crescentic glomerulonephritis. The genetic performance of Sparc, Lcn2 and/or Spp1 can be used as biomarkers.
摘要翻译： 本发明公开了一种使用来自患者的至少一个样本来诊断月球性肾小球肾炎（CRGN）的方法。 该方法是找到用于诊断月球性肾小球肾炎的至少一种生物标志物。 Sparc，Lcn2和/或Spp1的遗传表现可用作生物标志物。
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5.发明申请METHOD FOR DIAGNOSING KIDNEY DISEASE COMPRISING DETECTING THE LEVEL OF ANNEXIN A2 OR S100A6 审中-公开检测包含ANNEXIN A2或S100A6水平的KIDNEY病的方法公开(公告)号：US20130101998A1
公开(公告)日：2013-04-25
申请号：US13618657
申请日：2012-09-14
申请人： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
发明人： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
摘要翻译： 本发明提供了用于检测肾病的生物标志物，其选自寡核苷酸序列，互补序列或衍生物，氨基酸序列或衍生物，片段，变体，膜联蛋白A2或S100A6的抗体或其组合。 此外，本发明还提供了用于肾脏疾病检测的测定试剂盒和方法，实际上用于由急性肾小管坏死引起的肾脏疾病。
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6.发明授权Method for diagnosing kidney disease comprising detecting the level of annexin A2 有权用于诊断肾脏疾病的方法，包括检测膜联蛋白A2的水平公开(公告)号：US08329410B2
公开(公告)日：2012-12-11
申请号：US12540146
申请日：2009-08-12
申请人： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
发明人： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
摘要翻译： 本发明提供了用于检测肾病的生物标志物，其选自寡核苷酸序列，互补序列或衍生物，氨基酸序列或衍生物，片段，变体，膜联蛋白A2或S100A6的抗体或其组合。 此外，本发明还提供了用于肾脏疾病检测的测定试剂盒和方法，实际上用于由急性肾小管坏死引起的肾脏疾病。
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公开(公告)号：US20100081142A1
公开(公告)日：2010-04-01
申请号：US12540146
申请日：2009-08-12
申请人： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
发明人： Ann Chen , Shuk-Man Ka , Chao-Wen Cheng , Jenn-Han Chen , Chen-Wen Yao
CPC分类号： G01N33/6893 , G01N2800/347
摘要： The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting, practically for the kidney disease resulting from acute tubular necrosis.
摘要翻译： 本发明提供了用于检测肾病的生物标志物，其选自寡核苷酸序列，互补序列或衍生物，氨基酸序列或衍生物，片段，变体，膜联蛋白A2或S100A6的抗体或其组合。 此外，本发明还提供了用于肾脏疾病检测的测定试剂盒和方法，实际上用于由急性肾小管坏死引起的肾脏疾病。
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8.发明授权Method for renal disease diagnosis and prognosis using annexin A1 and Rab23 as markers 有权使用膜联蛋白A1和Rab23作为标记物的肾脏疾病诊断和预后的方法公开(公告)号：US08329651B2
公开(公告)日：2012-12-11
申请号：US12486166
申请日：2009-06-17
申请人： Ann Chen , Hao-Ai Shui , Shuk-Man Ka
发明人： Ann Chen , Hao-Ai Shui , Shuk-Man Ka
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： Use of Annexin A1 or Rab23 as a biomarker for diagnosing kidney disease or assessing efficacy of kidney disease treatment.
摘要翻译： 使用Annexin A1或Rab23作为诊断肾脏疾病或评估肾脏疾病治疗效果的生物标志物。
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公开(公告)号：US09295705B2
公开(公告)日：2016-03-29
申请号：US13290519
申请日：2011-11-07
申请人： Ann Chen , Shuk-Man Ka , Rey-Yuh Wu , Jia-Ming Chang
发明人： Ann Chen , Shuk-Man Ka , Rey-Yuh Wu , Jia-Ming Chang
IPC分类号： A61K36/284 , A61K36/355 , A61K36/46 , A61K36/74 , A61K36/748
CPC分类号： A61K36/46 , A61K36/284 , A61K36/355 , A61K36/748 , A61K2300/00
摘要： This invention relates to methods for treatment of nephritis. This invention further provides a method of treating with nephritis comprising administering to the subject an amount of herbal pharmaceutical composition thereof effective to treat the subject. Move particularly, this invention provides an herbal pharmaceutical composition comprising Rhizoma Atractylodis macrocephalae, Eucommiae cortex, Lonicerae caulis, and Hedyotidis diffusae Herba thereof for use in treating a subject afflicted with active nephritis.
摘要翻译： 本发明涉及治疗肾炎的方法。 本发明进一步提供了一种治疗肾炎的方法，包括向受试者施用有效治疗受试者的量的草药组合物。 特别地，本发明提供了一种草药药物组合物，其包含白术大戟科，杜仲皮，金银花，以及禾本科植物禾本科植物，用于治疗患有活动性肾炎的受试者。
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公开(公告)号：US08518461B2
公开(公告)日：2013-08-27
申请号：US13448722
申请日：2012-04-17
申请人： Ann Chen , Kuo-Feng Hua , Shuk-Man Ka , Jia-Ming Chang , Yung-Jen Tsai
发明人： Ann Chen , Kuo-Feng Hua , Shuk-Man Ka , Jia-Ming Chang , Yung-Jen Tsai
IPC分类号： A01N65/00
CPC分类号： A61K36/899
摘要： The present invention relates to a method for treating inflammation comprising administering a subject in need thereof with a therapeutically effective amount of a composition comprising bamboo vinegar or the phenolic fraction thereof. The method for preparing the phenolic fraction is also provided.
摘要翻译： 本发明涉及一种治疗炎症的方法，其包括给予有需要的受试者治疗有效量的包含竹醋或其酚类组分的组合物。 还提供了制备酚类馏分的方法。
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