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1.发明授权Dimeric DTPA derivatives, their metal complexes and pharmaceutical agents containing these complexes 失效二聚DTPA衍生物，它们的金属配合物和含有这些配合物的药剂
公开(公告)号：US5695737A
公开(公告)日：1997-12-09
申请号：US476117
申请日：1995-06-07
申请人： Werner Krause , Franz Karl Maier , Michael Bauer , Gabriele Schuhmann-Giampieri , Wolf Press , Johannes Platzek , Heribert Schmitt-Willich
发明人： Werner Krause , Franz Karl Maier , Michael Bauer , Gabriele Schuhmann-Giampieri , Wolf Press , Johannes Platzek , Heribert Schmitt-Willich
IPC分类号： A61K51/00 , A61K49/00 , A61K49/06 , A61K51/04 , C07C227/18 , C07C229/16 , C07C229/36 , C07C229/76 , C07C237/06 , C07C237/08 , C07C317/28 , C07C323/25 , C07C229/00 , C07F5/00
CPC分类号： C07C237/08 , A61K49/06 , A61K51/048 , C07C229/16 , C07C229/36 , C07C229/76 , C07C237/06
摘要： The invention relates to new dimeric DTPA derivatives, their metal complexes, containing at least one ion of an element of atomic numbers 21-32, 37-39, 42-51 and 57-83, agents containing these complexes, their use in NMR diagnosis and/or diagnostic radiology, radiodiagnosis and radiotherapy, as well as process for their production.
摘要翻译： 本发明涉及新的二聚DTPA衍生物，其金属络合物，其含有至少一个原子序数21-32,37-39,42-51和57-83元素的离子，含有这些络合物的试剂，它们在NMR诊断中的用途 和/或诊断放射学，放射诊断和放射治疗，以及其生产过程。
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2.发明授权Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them 失效级联聚合物结合的络合化合物，其络合物和共轭物，其生产方法和含有它们的药剂公开(公告)号：US07208139B2
公开(公告)日：2007-04-24
申请号：US10953582
申请日：2004-09-30
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5/055
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21–29, 39, 42, 44 or 57–83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
摘要翻译： 含有复合物形成配体的级联聚合物，任选地是原子序数21-29,39,42,44或57-83的元素的至少五个离子，以及如果需要的话，无机和/或有机碱的阳离子， 氨基酸或氨基酸酰胺，是诊断和治疗的有价值的复合化合物和复合物。
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3.发明授权Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them 失效级联聚合物结合的络合化合物，其络合物和共轭物，其生产方法和含有它们的药剂公开(公告)号：US06855309B2
公开(公告)日：2005-02-15
申请号：US10316094
申请日：2002-12-11
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/12 , A61K51/00 , A61K51/06 , C07F5/00 , C07G99/00 , C08G69/48 , C08G73/00 , C08G73/02 , C08G83/00 , C08G85/00 , C09K3/00
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
摘要翻译： 含有复合物形成配体的级联聚合物，任选地是原子序数21-29,39,42,44或57-83的元素的至少五个离子，以及如果需要的话，无机和/或有机碱的阳离子， 氨基酸或氨基酸酰胺，是诊断和治疗的有价值的复合化合物和复合物。
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公开(公告)号：US06193950B1
公开(公告)日：2001-02-27
申请号：US09510363
申请日：2000-02-22
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5055
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
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公开(公告)号：US6054117A
公开(公告)日：2000-04-25
申请号：US156047
申请日：1998-09-17
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/12 , A61K51/00 , A61K51/06 , C07F5/00 , C07G99/00 , C08G69/48 , C08G73/00 , C08G73/02 , C08G83/00 , C08G85/00 , C09K3/00
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
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公开(公告)号：US5911971A
公开(公告)日：1999-06-15
申请号：US743535
申请日：1996-11-04
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/12 , A61K51/00 , A61K51/06 , C07F5/00 , C07G99/00 , C08G69/48 , C08G73/00 , C08G73/02 , C08G83/00 , C08G85/00 , C09K3/00
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
摘要翻译： 含有复合物形成配体的级联聚合物，任选地是原子序数21-29,39,42,44或57-83的元素的至少五个离子，以及如果需要的话，无机和/或有机碱的阳离子， 氨基酸或氨基酸酰胺，是诊断和治疗的有价值的复合化合物和复合物。
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公开(公告)号：US20050118105A1
公开(公告)日：2005-06-02
申请号：US10953582
申请日：2004-09-30
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/12 , A61K51/00 , A61K51/06 , C07F5/00 , C07G99/00 , C08G69/48 , C08G73/00 , C08G73/02 , C08G83/00 , C08G85/00 , C09K3/00
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
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8.发明授权Cascade polymer bound complexing compounds, their complexes and conjugates, process for their production and pharmaceutical agents containing them 失效级联聚合物结合的络合化合物，它们的络合物和共轭物，其制备方法和含有它们的药剂公开(公告)号：US06576222B2
公开(公告)日：2003-06-10
申请号：US09973836
申请日：2001-10-11
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5055
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
摘要翻译： 含有复合物形成配体的级联聚合物，任选地是原子序数21-29,39,42,44或57-83的元素的至少五个离子，以及如果需要的话，无机和/或有机碱的阳离子， 氨基酸或氨基酸酰胺，是诊断和治疗的有价值的复合化合物和复合物。
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公开(公告)号：US06299859B1
公开(公告)日：2001-10-09
申请号：US09628179
申请日：2000-07-28
申请人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
发明人： Johannes Platzek , Heribert Schmitt-Willich , Heinz Gries , Gabriele Schuhmann-Giampieri , Hubert Vogler , Hanns-Joachim Weinmann , Hans Bauer
IPC分类号： A61B5055
CPC分类号： C08G85/00 , A61K49/0002 , A61K49/04 , A61K49/06 , A61K49/085 , A61K49/124 , A61K51/04 , A61K51/065 , C08G83/003 , Y10S514/836 , Y10T436/24
摘要： Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
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10.发明授权Macrocyclic polymer complexing agents, their complexes, process for their production and pharmaceutical agents containing these compounds 失效大环聚合物络合剂，它们的络合物，其制备方法和含有这些化合物的药剂
公开(公告)号：US5876698A
公开(公告)日：1999-03-02
申请号：US881269
申请日：1992-05-11
申请人： Heribert Schmitt-Willich , Johannes Platzek , Heinz Gries , Gabriele Schuhmann-Giampieri , Thomas Frenzel
发明人： Heribert Schmitt-Willich , Johannes Platzek , Heinz Gries , Gabriele Schuhmann-Giampieri , Thomas Frenzel
IPC分类号： A61K49/00 , A61K49/04 , A61K49/08 , A61K51/00 , A61K51/06 , C08G69/10 , C08G69/48 , G01N31/00 , G01N33/48
CPC分类号： A61K51/065 , A61K49/085 , A61K49/106 , A61K49/146 , A61K2123/00
摘要： Polymeric compounds of general formula I(M).sub.n A (I)in whichM stands for the radical of a macrocyclic complexing agent,A stands for a backbone molecule, which shows a deficit of n amino groups, n hydroxy groups or n carboxy groups,n stands for the numbers 1 to 400, characterized in thatM, independent of one another, stands for complexing agents of general formula IA ##STR1## in which all variables are defined herein.
摘要翻译： 通式I（M）nA（I）的聚合化合物，其中M代表大环络合剂的基团，A代表主链分子，其表现出n个氨基，n个羟基或n个羧基的缺陷， n代表数字1至400，其特征在于，M彼此独立地代表通式IA（IA）的络合剂，其中所有变量在本文中定义。
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