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1.发明申请PROCESS FOR DEGRADING NITRILE RUBBERS IN THE PRESENCE OF CATALYSTS HAVING AN INCREASED ACTIVITY 审中-公开在具有增加活性的催化剂存在下降解氮化橡胶的方法公开(公告)号：US20120116026A1
公开(公告)日：2012-05-10
申请号：US13300874
申请日：2011-11-21
IPC分类号： C08F236/06
CPC分类号： C08C19/02 , C08C19/08 , C08C2019/09
摘要： A process of degrading nitrile rubbers comprises subjecting them to a metathesis reaction in the presence of specific catalysts with increased activity.
摘要翻译： 一种降解丁腈橡胶的方法包括在具有增加的活性的特定催化剂的存在下对它们进行复分解反应。
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2.发明授权公开(公告)号：US08609782B2
公开(公告)日：2013-12-17
申请号：US11707423
申请日：2007-02-16
IPC分类号： C08F36/02 , C08F20/44 , C08F220/44
CPC分类号： C08C19/02 , C08C19/08 , C08C2019/09
摘要： A process of degrading nitrile rubbers comprises subjecting them to a metathesis reaction in the presence of specific catalysts with increased activity.
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3.发明授权Metathesis of nitrile rubbers in the presence of transition metal complex catalysts 有权在过渡金属络合物催化剂存在下丁腈橡胶的复分解公开(公告)号：US08362154B2
公开(公告)日：2013-01-29
申请号：US12190840
申请日：2008-08-13
IPC分类号： C08F20/44
CPC分类号： C08C19/02 , B01J31/181 , B01J31/2265 , B01J2531/821 , C08C19/08 , C08C2019/09
摘要： A novel process for the metathetic degradation of nitrile rubbers is provided which uses specific transition metal complex catalysts showing an increased activity.
摘要翻译： 提供了一种用于丁腈橡胶的复分解降解的新方法，其使用显示增加的活性的特定的过渡金属络合物催化剂。
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4.发明申请Metathesis of Nitrile Rubbers In the Presence of Transition Metal Complex Catalysts 有权在过渡金属络合物催化剂存在下丁腈橡胶的复分解公开(公告)号：US20090054597A1
公开(公告)日：2009-02-26
申请号：US12190840
申请日：2008-08-13
CPC分类号： C08C19/02 , B01J31/181 , B01J31/2265 , B01J2531/821 , C08C19/08 , C08C2019/09
摘要： A novel process for the metathetic degradation of nitrile rubbers is provided which uses specific transition metal complex catalysts showing an increased activity.
摘要翻译： 提供了一种用于丁腈橡胶的复分解降解的新方法，其使用显示增加的活性的特定的过渡金属络合物催化剂。
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5.发明申请Process for degrading nitrile rubbers in the presence of catalysts having an increased activity 有权在具有增加的活性的催化剂存在下降解丁腈橡胶的方法公开(公告)号：US20080064822A1
公开(公告)日：2008-03-13
申请号：US11707423
申请日：2007-02-16
申请人： Werner Obrecht , Christopher Ong , Julia Muller , Oskar Nuyken
发明人： Werner Obrecht , Christopher Ong , Julia Muller , Oskar Nuyken
IPC分类号： C08C19/02
CPC分类号： C08C19/02 , C08C19/08 , C08C2019/09
摘要： A process of degrading nitrile rubbers comprises subjecting them to a metathesis reaction in the presence of specific catalysts with increased activity.
摘要翻译： 一种降解丁腈橡胶的方法包括在具有增加的活性的特定催化剂的存在下对它们进行复分解反应。
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公开(公告)号：US08765994B2
公开(公告)日：2014-07-01
申请号：US13213901
申请日：2011-08-19
申请人： Raymond Andersen , David E. Williams , Alice Mui , Christopher Ong , Gerald Krystal , Lu Yang
发明人： Raymond Andersen , David E. Williams , Alice Mui , Christopher Ong , Gerald Krystal , Lu Yang
IPC分类号： A61K31/21 , A61K31/075 , C07C69/76 , C07C43/21 , C07J63/00
CPC分类号： C07J63/00
摘要： The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.
摘要翻译： 本发明包括使用作为SHIP1活性调节剂的托泊醇，相关化合物及其药物组合物。 本发明还提供能够调节SHIP1活性的新型萜烯化合物及其合成方法。
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公开(公告)号：US20120329954A1
公开(公告)日：2012-12-27
申请号：US13391633
申请日：2010-08-27
IPC分类号： C08F8/04
CPC分类号： C08C19/02 , B01J31/181 , B01J31/1815 , B01J31/2265 , B01J31/2291 , B01J2231/641 , B01J2531/821 , B01J2531/825 , C08C19/08 , C08C2019/09 , C08L15/005
摘要： The present invention relates to a process for the production of hydrogenated nitrile rubber polymers having lower molecular weights and narrower molecular weight distributions than those known in the art, wherein the process is carried out in the presence of hydrogen and optionally at least one co-olefin. The present invention further relates to the use of specific metal compounds in a process for the production of a hydrogenated nitrile rubber by simultaneous hydrogenation and metathesis of a nitrile rubber.
摘要翻译： 本发明涉及生产具有比本领域已知的分子量低和分子量分布窄的氢化丁腈橡胶聚合物的方法，其中该方法在氢气和任选的至少一种共聚烯烃存在下进行 。 本发明还涉及通过丁腈橡胶的同时氢化和复分解在生产氢化丁腈橡胶的方法中使用特定的金属化合物。
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8.发明授权Process for removing ruthenium-containing catalyst residues from optionally hydrogenated nitrile rubber 有权从任选氢化丁腈橡胶中除去含钌催化剂残留物的方法公开(公告)号：US07846995B2
公开(公告)日：2010-12-07
申请号：US12336626
申请日：2008-12-17
IPC分类号： C08F6/16
CPC分类号： C08C2/04 , C08C2019/09 , C08L15/005
摘要： Novel optionally hydrogenated nitrile rubbers distinguised by a very low ruthenium content are provided as well as a process for the removal of ruthenium-containing catalyst residues from a solution of optionally hydrogenated nitrile rubber by using specific functionalized ion-exchange resins.
摘要翻译： 提供了由非常低的钌含量区分的新的任选氢化的丁腈橡胶，以及通过使用特定的官能化离子交换树脂从任选氢化的丁腈橡胶的溶液中除去含钌催化剂残余物的方法。
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公开(公告)号：US20090281166A1
公开(公告)日：2009-11-12
申请号：US12423359
申请日：2009-04-14
申请人： Martin Gleave , Christopher Ong , Norihiro Hayashi
发明人： Martin Gleave , Christopher Ong , Norihiro Hayashi
IPC分类号： A61K31/7088 , C12Q1/68 , C12Q1/42 , A61K31/519 , A61K31/435 , A61K31/4355 , A61K31/05
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/158 , G01N33/57484
摘要： A cancer is evaluated for selection of appropriate therapy by evaluating a sample of cancerous tissue to determine an expression of level of phosphatase and tensin homologue deleted from chromosome 10 (PTEN); and in the case where the expression level of functional PTEN is below a threshold level, identifying the cancer as susceptible to an active agent that inhibits the expression of heat shock protein 27 (hsp27). The evaluation may be included as part of a method of treatment, in which an hsp27 inhibitor is selected as a therapeutic agent when the PTEN level is below the threshold.
摘要翻译： 通过评估癌组织样品来评估癌症的选择以确定从10号染色体（PTEN）缺失的磷酸酶和张力蛋白同源物的水平的表达; 并且在功能性PTEN的表达水平低于阈值水平的情况下，鉴定对抑制热休克蛋白27（hsp27）表达的活性剂敏感的癌症。 评价可以作为治疗方法的一部分被包括，其中当PTEN水平低于阈值时，选择hsp27抑制剂作为治疗剂。
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公开(公告)号：US09079979B2
公开(公告)日：2015-07-14
申请号：US13391633
申请日：2010-08-27
CPC分类号： C08C19/02 , B01J31/181 , B01J31/1815 , B01J31/2265 , B01J31/2291 , B01J2231/641 , B01J2531/821 , B01J2531/825 , C08C19/08 , C08C2019/09 , C08L15/005
摘要： The present invention relates to a process for the production of hydrogenated nitrile rubber polymers having lower molecular weights and narrower molecular weight distributions than those known in the art, wherein the process is carried out in the presence of hydrogen and optionally at least one co-olefin. The present invention further relates to the use of specific metal compounds in a process for the production of a hydrogenated nitrile rubber by simultaneous hydrogenation and metathesis of a nitrile rubber.
摘要翻译： 本发明涉及生产具有比本领域已知的分子量低和分子量分布窄的氢化丁腈橡胶聚合物的方法，其中该方法在氢气和任选的至少一种共聚烯烃存在下进行 。 本发明还涉及通过丁腈橡胶的同时氢化和复分解在生产氢化丁腈橡胶的方法中使用特定的金属化合物。
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