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92 条记录 (耗时 0.052 秒)

    N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors
    4.
    发明授权
    N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors 有权
    N-嘧啶-4-基-3-氨基 - 吡咯并[3,4-c]吡唑衍生物作为PKC激酶抑制剂

    公开(公告)号：US08183255B2

    公开(公告)日：2012-05-22

    申请号：US12523965

    申请日：2008-02-04

    申请人： Hui Li ,  Seiji Nukui ,  Stephanie Anne Scales ,  Min Teng ,  Chunfeng Yin

    发明人： Hui Li ,  Seiji Nukui ,  Stephanie Anne Scales ,  Min Teng ,  Chunfeng Yin

    IPC分类号： A61K31/505

    CPC分类号： C07D519/00 ,  C07D487/04

    摘要： The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: (A) and (B) wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disease pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.

    摘要翻译： 本发明涉及式A和B的化合物和药学上可接受的盐：（A）和（B）其中A，B，R1，R2，R3，R4，R5，R6，R7，R8，R9和R10如上所定义 以上。 本发明还涉及包含该化合物和药学上可接受的盐的药物组合物以及治疗糖尿病及其并发症，癌症，局部缺血，炎症，中枢神经系统疾病，心血管疾病，阿尔茨海默病和皮肤病疾病压迫，病毒疾病，炎性反应的方法 疾病或肝脏是靶器官的疾病。

    N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors
    6.
    发明授权
    N-pyrimidin-4-yl-3-amino-pyrrolo[3,4-c]pyrazole derivatives as PKC kinase inhibitors 有权
    N-嘧啶-4-基-3-氨基 - 吡咯并[3,4-c]吡唑衍生物作为PKC激酶抑制剂

    公开(公告)号：US08877761B2

    公开(公告)日：2014-11-04

    申请号：US13450388

    申请日：2012-04-18

    申请人： Hui Li ,  Seiji Nukui ,  Stephanie Anne Scales ,  Min Teng ,  Chunfeng Yin

    发明人： Hui Li ,  Seiji Nukui ,  Stephanie Anne Scales ,  Min Teng ,  Chunfeng Yin

    IPC分类号： A01N43/54 ,  C07D403/00 ,  C07D487/04

    CPC分类号： C07D519/00 ,  C07D487/04

    摘要： The present invention relates to compounds and pharmaceutically acceptable salts of Formulas A and B: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined above. The invention further relates to pharmaceutical compositions comprising the compounds and pharmaceutically acceptable salts and to methods of treating diabetes mellitus and its complications, cancer, ischemia, inflammation, central nervous system disorders, cardiovascular disease, Alzheimer's disease and dermatological disase pression, virus diseases, inflammatory disorders, or diseases in which the liver is a target organ.

    摘要翻译： 本发明涉及式A和B的化合物和药学上可接受的盐：其中A，B，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和R 10如上所定义。 本发明还涉及包含该化合物和药学上可接受的盐的药物组合物以及治疗糖尿病及其并发症，癌症，局部缺血，炎症，中枢神经系统疾病，心血管疾病，阿尔茨海默氏病和皮肤病学抑制的病毒病，炎性疾病 疾病或肝脏是靶器官的疾病。

    Aminopyrazole compounds
    10.
    发明申请
    Aminopyrazole compounds 审中-公开
    氨基吡唑化合物

    公开(公告)号：US20050043381A1

    公开(公告)日：2005-02-24

    申请号：US10897849

    申请日：2004-07-22

    申请人： Michael Johnson ,  Min Teng ,  Jinjiang Zhu

    发明人： Michael Johnson ,  Min Teng ,  Jinjiang Zhu

    IPC分类号： A61P35/00 ,  C07D231/38 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  A61K31/425 ,  C07D275/02

    CPC分类号： C04B35/632 ,  C07D231/38 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

    摘要： Described herein are aminopyrazole compounds of formula I: wherein R1, R2, L and Ar are as defined in the specification. Such compounds are capable of modulating the activity of a checkpoint kinase and methods for utilizing such modulation to treat cell proliferative disorders. Also described are pharmaceutical compositions containing such compounds. Also described are the therapeutic or prophylactic use of such compounds and compositions, and methods of treating cancer as well as other diseases associated with unwanted cellular proliferation, by administering effective amounts of such compounds in combination with anti-neoplastic agents.

    摘要翻译： 本文描述的是式I的氨基吡唑化合物：其中R 1，R 2，L和Ar如说明书中所定义。 这些化合物能够调节检查点激酶的活性和利用这种调节来治疗细胞增殖性疾病的方法。 还描述了含有这些化合物的药物组合物。 还描述了这样的化合物和组合物的治疗或预防用途，以及通过与抗肿瘤剂组合施用有效量的这种化合物来治疗癌症以及与不想要的细胞增殖相关的其它疾病的方法。