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    Method and apparatus for the manufacture of a product having a substance embedded in a carrier
    1.
    发明授权
    Method and apparatus for the manufacture of a product having a substance embedded in a carrier 失效
    用于制造具有嵌入在载体中的物质的产品的方法和装置

    公开(公告)号：US5043280A

    公开(公告)日：1991-08-27

    申请号：US287918

    申请日：1988-12-21

    申请人： Wilfried Fischer ,  Bernd W. Muller

    发明人： Wilfried Fischer ,  Bernd W. Muller

    IPC分类号： A61J3/00 ,  A61J3/06 ,  A61J3/07 ,  A61K9/16 ,  A61K9/18 ,  A61K9/22 ,  A61K9/26 ,  B01J13/04

    CPC分类号： A61K9/1694 ,  B01J13/043

    摘要： A sterile product containing a substance embedded in a carrier is produced by use of a supercritical gas. In one embodiment, a mixture is formed of a substance, carrier and supercritical gas such as nitrous oxide or carbon dioxide, and the supercritical gas is separated from the substance and carrier to obtain the product. In another embodiment, the supercritical gas contains the substance, and is mixed with an atomized organic solvent containing the carrier to form a mixture. The supercritical gas extracts the solvent, and is separated from the substance and carrier to produce the product. Alternatively, the carrier can be in the supercritical gas and the substance in the solvent, or both the substance and carrier can be in the solvent. Atomization and formation of the mixture can be carried out by feeding the supercritical gas and solvent through a nozzle into a spray tower or column. The supercritical gas containing the solvent is separated to obtain the product in the form of a dry powder containing spheres of the carrier having the substance embedded therein. The carrier can be polymers, lipids, lecithins or waxes, and the substance can be medicines, toxins, viruses, diagnostic materials, herbicides, insecticides or pesticides. An apparatus for carrying out the method contains a spray tower and other means for performing the method steps.

    摘要翻译： 通过使用超临界气体制备含有嵌入载体中的物质的无菌产品。 在一个实施方案中，由物质，载体和超临界气体如一氧化二氮或二氧化碳形成混合物，并且超临界气体与物质和载体分离以获得产物。 在另一个实施方案中，超临界气体含有物质，并与含有载体的雾化有机溶剂混合以形成混合物。 超临界气体提取溶剂，并与物质和载体分离以产生产物。 或者，载体可以在超临界气体中，溶剂中的物质，或物质和载体都可以在溶剂中。 混合物的雾化和形成可以通过将超临界气体和溶剂通过喷嘴进料到喷雾塔或塔中来进行。 分离含有溶剂的超临界气体，得到含有嵌入物质的载体球的干粉形式的产物。 载体可以是聚合物，脂质，卵磷脂或蜡，该物质可以是药物，毒素，病毒，诊断材料，除草剂，杀虫剂或杀虫剂。 用于执行该方法的装置包括喷雾塔和用于执行方法步骤的其它装置。

    Stable galenic freeze-dried pharmaceutical preparation of recombinant carbohydrate-binding polypeptides
    2.
    发明授权
    Stable galenic freeze-dried pharmaceutical preparation of recombinant carbohydrate-binding polypeptides 有权
    稳定的盖仑冷冻干燥的重组碳水化合物结合多肽的药物制剂

    公开(公告)号：US08377654B2

    公开(公告)日：2013-02-19

    申请号：US13102670

    申请日：2011-05-06

    申请人： Oliver Gloger ,  Bernd W. Muller ,  Klaus Witthohn

    发明人： Oliver Gloger ,  Bernd W. Muller ,  Klaus Witthohn

    IPC分类号： C12P21/06 ,  A61K9/19

    CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K38/168 ,  A61K47/02 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36

    摘要： The invention relates to a method for the production of a medicament containing a polypeptide comprising at least one recombinant carbohydrate-binding polypeptide, or a functional fragment or derivative of said carbohydrate-binding polypeptide in a form stable for storage. The polypeptide mentioned comprises polypeptides or functional derivatives thereof, which are fused with cytotoxically effective peptides to give fusion proteins, or which are linked to another polypeptide having a cytotoxic activity. Moreover, the invention describes further formulating of the disclosed medicaments to medicaments with different pharmaceutical forms.

    摘要翻译： 本发明涉及一种生产含有多肽的药物的方法，所述多肽包含至少一种重组碳水化合物结合多肽，或所述碳水化合物结合多肽的功能性片段或衍生物，其形式稳定存放。 所提及的多肽包括多肽或其功能性衍生物，其与细胞毒性有效的肽融合以产生融合蛋白，或与另外具有细胞毒活性的多肽相连。 此外，本发明描述了将所公开的药物进一步配制成具有不同药物形式的药物。

    STABLE GALENIC FREEZE-DRIED PHARMACEUTICAL PREPARATION OF RECOMBINANT CARBOHYDRATE-BINDING POLYPEPTIDES
    4.
    发明申请
    STABLE GALENIC FREEZE-DRIED PHARMACEUTICAL PREPARATION OF RECOMBINANT CARBOHYDRATE-BINDING POLYPEPTIDES 审中-公开
    重组碳氢化合物结合多糖的稳定的冷冻干燥药物制备

    公开(公告)号：US20090162340A1

    公开(公告)日：2009-06-25

    申请号：US12327345

    申请日：2008-12-03

    申请人： Oliver Gloger ,  Bernd W. Muller ,  Klaus Witthohn

    发明人： Oliver Gloger ,  Bernd W. Muller ,  Klaus Witthohn

    IPC分类号： A61K38/47 ,  A61P39/00

    CPC分类号： A61K9/19 ,  A61K9/0019 ,  A61K38/168 ,  A61K47/02 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26 ,  A61K47/36

    摘要： The invention relates to a method for the production of a medicament containing a polypeptide comprising at least one recombinant carbohydrate-binding polypeptide, or a functional fragment or derivative of said carbohydrate-binding polypeptide in a form stable for storage. The polypeptide mentioned comprises polypeptides or functional derivatives thereof, which are fused with cytotoxically effective peptides to give fusion proteins, or which are linked to another polypeptide having a cytotoxic activity. Moreover, the invention describes further formulating of the disclosed medicaments to medicaments with different pharmaceutical forms.

    摘要翻译： 本发明涉及一种生产含有多肽的药物的方法，所述多肽包含至少一种重组碳水化合物结合多肽，或所述碳水化合物结合多肽的功能性片段或衍生物，其形式稳定存放。 所提及的多肽包括多肽或其功能性衍生物，其与细胞毒性有效的肽融合以产生融合蛋白，或与另外具有细胞毒活性的多肽相连。 此外，本发明描述了将所公开的药物进一步配制成具有不同药物形式的药物。

    Process for the production of pseudolatices and micro- or nanoparticles and pharmaceutical preparations containing them
    6.
    发明授权
    Process for the production of pseudolatices and micro- or nanoparticles and pharmaceutical preparations containing them 失效
    用于制备假胶束和含有微粒或纳米颗粒的药物制剂的方法

    公开(公告)号：US5919408A

    公开(公告)日：1999-07-06

    申请号：US531283

    申请日：1995-09-20

    申请人： Bernd W. Muller ,  Felix Junis-Specht

    发明人： Bernd W. Muller ,  Felix Junis-Specht

    IPC分类号： A61K9/16 ,  A61K9/19 ,  A61K9/51 ,  C08J3/03 ,  C08J3/12 ,  C08L1/28 ,  C08L93/02 ,  C08J3/16

    CPC分类号： A61K9/5153 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/5192 ,  B82Y5/00 ,  C08J3/03 ,  C08J3/12 ,  C08L1/28 ,  C08L93/02 ,  Y10S977/788

    摘要： The invention relates to a process for the production of pseudolatices or micro- and/or nanoparticles, in which a polymer is crystalline, partially crystalline or amorphous, is selected from cellulose derivatives, poly(meth)acrylates, shellac, polylactides, polylactide/polyglycolide mixtures, polyhydroxy butyric acids or polycyanoacrylates and is heated to a temperature above its glass transition temperature and then high-pressure homogenized in water or an aqueous buffer solution and this suspension is converted, if necessary, into micro- and/or nanoparticles by drying. Medicaments can be worked into the pseudolatices, micro- and/or nanoparticles.

    摘要翻译： 本发明涉及一种制备假胶体或微米和/或纳米颗粒的方法，其中聚合物是结晶的，部分结晶的或无定形的，选自纤维素衍生物，聚（甲基）丙烯酸酯，虫胶，聚丙交酯，聚丙交酯/聚乙交酯 混合物，多羟基丁酸或聚氰基丙烯酸酯，并加热到高于其玻璃化转变温度的温度，然后在水或缓冲溶液中高压均质化，如果需要，该悬浮液通过干燥转化成微米和/或纳米颗粒。 可以将药物加工成伪溶剂，微量和/或纳米颗粒。