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公开(公告)号：US08466118B2
公开(公告)日：2013-06-18
申请号：US12597458
申请日：2008-04-23
CPC分类号： C07K14/705 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/31 , C12Y306/03014
摘要： There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.
摘要翻译： 已经公开了抑制血脑屏障蛋白（BBBP）的药剂。 这些试剂可用于控制进入和离开CNS的试剂。 这允许药物更有效和/或允许降低药物的副作用。
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公开(公告)号：US20100196393A1
公开(公告)日：2010-08-05
申请号：US12597458
申请日：2008-04-23
IPC分类号： A61K31/713 , A61K39/395 , A61K38/02 , A61P35/00 , A61P25/28 , A61P25/16 , A61P9/10 , A61P25/08 , C07H21/04
CPC分类号： C07K14/705 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/31 , C12Y306/03014
摘要： There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.
摘要翻译： 已经公开了抑制血脑屏障蛋白（BBBP）的药剂。 这些试剂可用于控制进入和离开CNS的试剂。 这允许药物更有效和/或允许降低药物的副作用。
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公开(公告)号：US20110166197A1
公开(公告)日：2011-07-07
申请号：US12918402
申请日：2009-02-19
CPC分类号： C07K14/4711 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2310/3525
摘要： Antisense nucleic acids, compositions and methods are provided for modulating the expression of an amyloid beta protein (AβP) portion of the amyloid precursor protein (APP) coding sequence. The compositions comprise antisense nucleic acids targeted to nucleic acids encoding amyloid precursor protein. Methods of using these nucleic acids for modulation of amyloid precursor protein expression and for treatment of diseases and conditions associated with expression of the amyloid beta protein portion of the amyloid precursor protein are provided.
摘要翻译： 提供反义核酸，组合物和方法用于调节淀粉样蛋白前体蛋白（APP）编码序列的淀粉样蛋白β蛋白（A＆bgr; P）部分的表达。 组合物包含靶向编码淀粉样蛋白前体蛋白的核酸的反义核酸。 提供了使用这些核酸调节淀粉样蛋白前体蛋白表达和治疗与淀粉样蛋白前体蛋白的淀粉样蛋白β蛋白部分的表达相关的疾病和病症的方法。
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公开(公告)号：US20090304676A1
公开(公告)日：2009-12-10
申请号：US12093288
申请日：2006-11-10
IPC分类号： A61K39/395 , A61K38/17 , A61K31/7088 , A61P25/00
CPC分类号： A61K31/485
摘要： The present application provides methods and compositions for improving cognitive function and enhancing mental performance in subjects, including those suffering from memory deficiencies, by regulating the activity of beta amyloid (Aβ) in the brain of such subjects.
摘要翻译： 本申请通过调节这些受试者大脑中的β淀粉样蛋白（Abeta）的活性，提供了改善认知功能并提高受试者（包括记忆缺陷患者）的心理表现的方法和组合物。
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公开(公告)号：US06310048B1
公开(公告)日：2001-10-30
申请号：US09458481
申请日：1999-12-09
申请人： Vijaya B. Kumar
发明人： Vijaya B. Kumar
IPC分类号： A61K4800
CPC分类号： C12N15/11 , A61K48/00 , A61K2039/545 , C07K14/4711 , C07K14/8114
摘要： An antisense compound comprising nucleotides complementary to a nucleic acid sequence coding for amyloid precursor protein (APP), wherein the antisense compound inhibits the expression of an amyloid beta protein (A&bgr;P) portion of the amyloid precursor protein coding sequence while permitting the expression of at least a portion of the amyloid precursor protein polynucleotide 5′ to the A&bgr;P portion of the amyloid precursor protein coding sequence. Pharmaceutical compositions and formulations containing the compound and methods of using the compound to regulate A&bgr;P expression in cells and tissues and to treat disease are also provided.
摘要翻译： 包含与编码淀粉样蛋白前体蛋白（APP）的核酸序列互补的核苷酸的反义化合物，其中所述反义化合物抑制淀粉样蛋白前体蛋白质编码序列的淀粉样蛋白β蛋白（AbetaP）部分的表达，同时允许至少表达 一部分淀粉样蛋白前体蛋白多核苷酸5'与淀粉样蛋白前体蛋白编码序列的AbetaP部分。 还提供了含有该化合物的药物组合物和制剂以及使用该化合物调节细胞和组织中的AbetaP表达并治疗疾病的方法。
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