-
公开(公告)号：US20110166197A1
公开(公告)日：2011-07-07
申请号：US12918402
申请日：2009-02-19
CPC分类号： C07K14/4711 , C12N15/1138 , C12N2310/11 , C12N2310/321 , C12N2310/3525
摘要： Antisense nucleic acids, compositions and methods are provided for modulating the expression of an amyloid beta protein (AβP) portion of the amyloid precursor protein (APP) coding sequence. The compositions comprise antisense nucleic acids targeted to nucleic acids encoding amyloid precursor protein. Methods of using these nucleic acids for modulation of amyloid precursor protein expression and for treatment of diseases and conditions associated with expression of the amyloid beta protein portion of the amyloid precursor protein are provided.
摘要翻译： 提供反义核酸，组合物和方法用于调节淀粉样蛋白前体蛋白（APP）编码序列的淀粉样蛋白β蛋白（A＆bgr; P）部分的表达。 组合物包含靶向编码淀粉样蛋白前体蛋白的核酸的反义核酸。 提供了使用这些核酸调节淀粉样蛋白前体蛋白表达和治疗与淀粉样蛋白前体蛋白的淀粉样蛋白β蛋白部分的表达相关的疾病和病症的方法。
-
公开(公告)号：US08466118B2
公开(公告)日：2013-06-18
申请号：US12597458
申请日：2008-04-23
CPC分类号： C07K14/705 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/31 , C12Y306/03014
摘要： There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.
摘要翻译： 已经公开了抑制血脑屏障蛋白（BBBP）的药剂。 这些试剂可用于控制进入和离开CNS的试剂。 这允许药物更有效和/或允许降低药物的副作用。
-
公开(公告)号：US20100196393A1
公开(公告)日：2010-08-05
申请号：US12597458
申请日：2008-04-23
IPC分类号： A61K31/713 , A61K39/395 , A61K38/02 , A61P35/00 , A61P25/28 , A61P25/16 , A61P9/10 , A61P25/08 , C07H21/04
CPC分类号： C07K14/705 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/31 , C12Y306/03014
摘要： There are disclosed agents that inhibit Blood Brain Barrier Proteins (BBBP). Such agents are useful in controlling agents entering and exiting the CNS. This allows for drugs to be more effective and/or allowing side effects of the drugs to be lowered.
摘要翻译： 已经公开了抑制血脑屏障蛋白（BBBP）的药剂。 这些试剂可用于控制进入和离开CNS的试剂。 这允许药物更有效和/或允许降低药物的副作用。
-
公开(公告)号：US20070191523A1
公开(公告)日：2007-08-16
申请号：US11595449
申请日：2006-11-09
申请人： Bradford Wayland , Zhi Lu , Alexei Gridnev , Thomas Darling
发明人： Bradford Wayland , Zhi Lu , Alexei Gridnev , Thomas Darling
IPC分类号： C08K5/07
CPC分类号： C08F6/02 , C08F220/18
摘要： Methods of producing decolorized homo- and co-polymers through polymerization of monomers in presence of cobalt-complexed tetraphenyl porphyrin derivatives and decolorization of the produced polymer by exposing the polymer to a sorbent and, optionally, a solvent are disclosed herein.
摘要翻译： 在钴络合的四苯基卟啉衍生物的存在下通过单体聚合生产脱色的均聚物和共聚物的方法，以及通过将聚合物暴露于吸附剂和任选的溶剂而使生产的聚合物脱色的方法在本文中公开。
-
公开(公告)号：US20050054767A1
公开(公告)日：2005-03-10
申请号：US10886454
申请日：2004-07-07
IPC分类号： C08F4/04 , C08F4/28 , C08F120/06 , C08K5/00 , C08K5/24 , C08K5/34 , C09D20060101
CPC分类号： C08F220/14 , C08F2/38 , C08F220/18 , C08F220/26 , C08K5/0025 , C08L33/08 , C08L101/02 , C08L2205/02 , C09D133/08 , C08L2666/04 , C08L33/06
摘要： This invention relates to rapid curing coating compositions that are particularly useful for automotive OEM and refinish applications. The coating composition includes a crosslinkable component that contains a novel highly branched acrylic polymer, and a crosslinking component that contains conventional crosslinking agents, such as polyisocyanate and melamine. This invention is also directed to a process for producing coatings from the rapid curing coating compositions. These compositions are especially useful in providing hard highly crosslinked coatings.
摘要翻译： 本发明涉及对汽车OEM和修补漆应用特别有用的快速固化涂料组合物。 涂料组合物包含含有新型高支化丙烯酸类聚合物的交联组分和含有常规交联剂如多异氰酸酯和三聚氰胺的交联组分。 本发明还涉及从快速固化涂料组合物制备涂料的方法。 这些组合物特别可用于提供硬的高度交联的涂层。
-
-
-
-
搜索结果
5 条记录 (耗时 0.029 秒)
