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    SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL
    2.
    发明申请
    SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL 有权
    生物可降解材料中的SULINDAC配方

    公开(公告)号：US20090264531A1

    公开(公告)日：2009-10-22

    申请号：US12413236

    申请日：2009-03-27

    申请人： John M. Zanella ,  Vanja M. King ,  Christopher M. Hobot ,  S. Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F. McKay ,  Kathy L. Remsen

    发明人： John M. Zanella ,  Vanja M. King ,  Christopher M. Hobot ,  S. Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F. McKay ,  Kathy L. Remsen

    IPC分类号： A61K31/192 ,  A61P25/00 ,  A61P29/00

    CPC分类号： A61K31/255 ,  A61K9/0024 ,  A61K9/204

    摘要： Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的舒林酸或其药学上可接受的盐，可以减轻由不同来源引起的疼痛和/或炎症，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位， 狭窄，恶性背痛和关节疼痛以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天，至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER
    5.
    发明申请
    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER 审中-公开
    生物可降解聚合物载体中的磺胺嘧啶配方

    公开(公告)号：US20090264478A1

    公开(公告)日：2009-10-22

    申请号：US12105375

    申请日：2008-04-18

    申请人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    发明人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    IPC分类号： A61K31/4402 ,  A61P29/00

    CPC分类号： A61K31/635 ,  A61K9/0024 ,  A61K47/34

    摘要： Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间的急性疼痛和/或炎症的有效治疗。 通过在目标部位或其附近施用有效量的柳氮磺吡啶可以减轻由不同来源引起的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    LOCALLY ADMINISTRATED LOW DOSES OF CORTICOSTEROIDS
    9.
    发明申请
    LOCALLY ADMINISTRATED LOW DOSES OF CORTICOSTEROIDS 审中-公开
    局部管理低剂量的角质层

    公开(公告)号：US20080317805A1

    公开(公告)日：2008-12-25

    申请号：US11765040

    申请日：2007-06-19

    申请人： William F. McKay ,  John Myers Zanella ,  Christopher M. Hobot

    发明人： William F. McKay ,  John Myers Zanella ,  Christopher M. Hobot

    IPC分类号： A61K31/566 ,  A61K31/56 ,  A61K9/00 ,  A61P25/04

    CPC分类号： A61K31/58 ,  A61K9/0024 ,  A61K31/56 ,  A61K31/566 ,  A61K31/573

    摘要： This invention provides for using a locally delivered low dose of a corticosteroid to treat pain caused by any inflammatory disease including sciatica, herniated disc, stenosis, mylopathy, low back pain, facet pain, osteoarthritis, rheumatoid arthritis, osteolysis, tendonitis, carpal tunnel syndrome, or tarsal tunnel syndrome. More specifically, a locally delivered low dose of a corticosteroid can be released into the epidural space, perineural space, or the foramenal space at or near the site of a patient's pain by a drug pump or a biodegradable drug depot.

    摘要翻译： 本发明提供使用局部递送的低剂量皮质类固醇来治疗由任何炎性疾病引起的疼痛，包括坐骨神经痛，椎间盘突出症，狭窄症，脊髓病，腰背痛，小平面疼痛，骨关节炎，类风湿性关节炎，骨质溶解，腱炎，腕管综合征 ，或t疮综合征。 更具体地，局部递送的低剂量的皮质类固醇可以通过药物泵或可生物降解的药物贮库释放到患者的疼痛部位处或附近的硬膜外腔，神经周围区域或其附近的孔内空间。