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1.发明申请ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF INFLAMMATORY DISEASES 有权治疗炎症性疾病的ALPHA ADRENERGIC RECEPTOR AGONISTS公开(公告)号：US20090263450A1
公开(公告)日：2009-10-22
申请号：US12422624
申请日：2009-04-13
申请人： John Myers ZANELLA , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
发明人： John Myers ZANELLA , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
IPC分类号： A61K31/4168 , A61F2/00 , A61P25/00 , A61P29/00
CPC分类号： A61K31/137 , A61K9/0024 , A61K9/14 , A61K31/415 , A61K31/4162
摘要： Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a target site, one can reduce, prevent or treat pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease.
摘要翻译： 提供了对肌腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或口腔面部疾病的疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的至少一种α肾上腺素能激动剂，可以减少，预防或治疗由腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或 口腔疾病。
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2.发明授权公开(公告)号：US08956641B2
公开(公告)日：2015-02-17
申请号：US12422624
申请日：2009-04-13
申请人： John Myers Zanella , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
发明人： John Myers Zanella , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
IPC分类号： A61K9/14 , A61K31/4162 , A61K31/137 , A61K9/00 , A61K31/415
CPC分类号： A61K31/137 , A61K9/0024 , A61K9/14 , A61K31/415 , A61K31/4162
摘要： Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a target site, one can reduce, prevent or treat pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease.
摘要翻译： 提供了对肌腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或口腔面部疾病的疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的至少一种α肾上腺素能激动剂，可以减少，预防或治疗由腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或 口腔疾病。
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3.发明授权公开(公告)号：US08956636B2
公开(公告)日：2015-02-17
申请号：US12388635
申请日：2009-02-19
申请人： Amira Wohabrebbi , William F. McKay , Christopher M. Hobot , Keith R. Hildebrand , Edward Phillip McDonald
发明人： Amira Wohabrebbi , William F. McKay , Christopher M. Hobot , Keith R. Hildebrand , Edward Phillip McDonald
CPC分类号： A61K31/407 , A61K9/0024 , A61K9/1647 , A61K49/0404 , A61K49/0419
摘要： Methods and compositions are provided for reducing, treating or preventing postoperative pain or inflammation in a patient in need of such treatment, the methods and compositions comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of ketorolac or pharmaceutically acceptable salt thereof to a target tissue site, wherein the drug depot releases an effective amount of ketorolac or pharmaceutically acceptable salt thereof over a period of 3 to 10 days.
摘要翻译： 提供了用于在需要这种治疗的患者中减少，治疗或预防术后疼痛或炎症的方法和组合物，所述方法和组合物包括给予包含治疗有效量的酮咯酸或其药学上可接受的盐的一种或多种可生物降解的药物宿主 靶组织部位，其中药物库在3至10天的时间内释放有效量的酮咯酸或其药学上可接受的盐。
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4.发明申请METHODS AND COMPOSITIONS FOR TREATING POSTOPERATIVE PAIN COMPROSING KETOROLAC 有权用于治疗包括KETOROLAC的术后疼痛的方法和组合物公开(公告)号：US20090263319A1
公开(公告)日：2009-10-22
申请号：US12388635
申请日：2009-02-19
申请人： Amira Wohabrebbi , William F. McKay , Christopher M. Hobot , Keith R. Hildebrand , Edward Phillip McDonald
发明人： Amira Wohabrebbi , William F. McKay , Christopher M. Hobot , Keith R. Hildebrand , Edward Phillip McDonald
IPC分类号： A61K51/00 , A61K31/407 , A61K9/10 , A61F13/00
CPC分类号： A61K31/407 , A61K9/0024 , A61K9/1647 , A61K49/0404 , A61K49/0419
摘要： Methods and compositions are provided for reducing, treating or preventing postoperative pain or inflammation in a patient in need of such treatment, the methods and compositions comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of ketorolac or pharmaceutically acceptable salt thereof to a target tissue site, wherein the drug depot releases an effective amount of ketorolac or pharmaceutically acceptable salt thereof over a period of 3 to 10 days.
摘要翻译： 提供了用于在需要这种治疗的患者中减少，治疗或预防术后疼痛或炎症的方法和组合物，所述方法和组合物包括给予包含治疗有效量的酮咯酸或其药学上可接受的盐的一种或多种可生物降解的药物宿主 靶组织部位，其中药物库在3至10天的时间内释放有效量的酮咯酸或其药学上可接受的盐。
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公开(公告)号：US08940315B2
公开(公告)日：2015-01-27
申请号：US12426031
申请日：2009-04-17
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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公开(公告)号：US20090263448A1
公开(公告)日：2009-10-22
申请号：US12412024
申请日：2009-03-26
IPC分类号： A61K9/00
CPC分类号： A61K31/4168 , A61K9/0019 , A61K9/0024 , A61K9/0085 , A61K9/06 , A61K9/1647 , A61K31/415 , A61K47/34
摘要： Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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公开(公告)号：US20090208554A1
公开(公告)日：2009-08-20
申请号：US12426021
申请日：2009-04-17
IPC分类号： A61F2/04 , A61K31/195
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of baclofen formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗包括给药一种或多种药物储库，其中药物贮库包括配制在聚原酸酯内的有效量的巴氯芬。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。
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公开(公告)号：US20090202604A1
公开(公告)日：2009-08-13
申请号：US12426031
申请日：2009-04-17
IPC分类号： A61F13/00 , A61K31/551
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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公开(公告)号：US08475823B2
公开(公告)日：2013-07-02
申请号：US12426021
申请日：2009-04-17
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of baclofen formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗包括给药一种或多种药物储库，其中药物贮库包括配制在聚原酸酯内的有效量的巴氯芬。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。
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公开(公告)号：US20090202436A1
公开(公告)日：2009-08-13
申请号：US12426005
申请日：2009-04-17
IPC分类号： A61K51/06 , A61L31/16 , A61P29/00 , A61K31/445
CPC分类号： A61K31/445 , A61K9/0024 , A61K9/0085 , A61K9/1641 , A61K9/1694 , A61K9/5031 , A61L31/16 , A61L2300/402 , A61L2300/602
摘要： Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of bupivacaine formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供有效的治疗疼痛，如慢性盆腔疼痛，延长时间。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的布比卡因。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。
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