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    SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL
    2.
    发明申请
    SULINDAC FORMULATIONS IN A BIODEGRADABLE MATERIAL 有权
    生物可降解材料中的SULINDAC配方

    公开(公告)号：US20090264531A1

    公开(公告)日：2009-10-22

    申请号：US12413236

    申请日：2009-03-27

    申请人： John M. Zanella ,  Vanja M. King ,  Christopher M. Hobot ,  S. Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F. McKay ,  Kathy L. Remsen

    发明人： John M. Zanella ,  Vanja M. King ,  Christopher M. Hobot ,  S. Mark Cox ,  Danielle Biggs ,  Katara Shaw ,  William F. McKay ,  Kathy L. Remsen

    IPC分类号： A61K31/192 ,  A61P25/00 ,  A61P29/00

    CPC分类号： A61K31/255 ,  A61K9/0024 ,  A61K9/204

    摘要： Effective treatments of pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulindac or a pharmaceutically acceptable salt thereof at or near a target site, one can relieve pain and/or inflammation caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days, at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的舒林酸或其药学上可接受的盐，可以减轻由不同来源引起的疼痛和/或炎症，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位， 狭窄，恶性背痛和关节疼痛以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天，至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER
    3.
    发明申请
    SULFASALAZINE FORMULATIONS IN A BIODEGRADABLE POLYMER CARRIER 审中-公开
    生物可降解聚合物载体中的磺胺嘧啶配方

    公开(公告)号：US20090264478A1

    公开(公告)日：2009-10-22

    申请号：US12105375

    申请日：2008-04-18

    申请人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    发明人： Stephen M. Cox ,  Christopher M. Hobot ,  John M. Zanella ,  Vanja M. King ,  William F. McKay ,  Kathy L. Remsen

    IPC分类号： A61K31/4402 ,  A61P29/00

    CPC分类号： A61K31/635 ,  A61K9/0024 ,  A61K47/34

    摘要： Effective treatments of acute pain and/or inflammation for extended periods of time are provided. Through the administration of an effective amount of sulfasalazine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长时间的急性疼痛和/或炎症的有效治疗。 通过在目标部位或其附近施用有效量的柳氮磺吡啶可以减轻由不同来源引起的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

    Synergistic antimicrobial compositions containing a halogenated acetophenone and an organic acid
    7.
    发明授权
    Synergistic antimicrobial compositions containing a halogenated acetophenone and an organic acid 失效
    含有卤代苯乙酮和有机酸的协同抗菌组合物

    公开(公告)号：US5441981A

    公开(公告)日：1995-08-15

    申请号：US186917

    申请日：1994-01-27

    申请人： David Oppong ,  Vanja M. King

    发明人： David Oppong ,  Vanja M. King

    IPC分类号： A01N35/04 ,  A01N37/02 ,  A01N37/06 ,  A01N37/14 ,  A01N37/36 ,  A01N37/40 ,  A01N35/00 ,  A01N37/10

    CPC分类号： A01N35/04

    摘要： Compositions for controlling the growth of microorganisms in or on a product, material or medium comprising synergistically effective amounts of halogenated acetophenones, such as 2-bromo-4-hydroxyacetophenone, and at least one organic acid, its salt or ester are disclosed. Methods to control the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.

    摘要翻译： 公开了用于控制包含协同有效量的卤代苯乙酮（例如2-溴-4-羟基苯乙酮）和至少一种有机酸，其盐或酯的产物，材料或介质中或其上的微生物生长的组合物。 还公开了使用本发明的组合物来控制微生物生长并防止由微生物引起的变质的方法。

    Release of BMP, bioactive agents and/or cells via a pump into a carrier matrix
    9.
    发明申请
    Release of BMP, bioactive agents and/or cells via a pump into a carrier matrix 有权
    通过泵将BMP，生物活性剂和/或细胞释放到载体基质中

    公开(公告)号：US20080025987A1

    公开(公告)日：2008-01-31

    申请号：US11494237

    申请日：2006-07-27

    申请人： Neil Beals ,  Jeffrey L. Scifert ,  Vanja M. King

    发明人： Neil Beals ,  Jeffrey L. Scifert ,  Vanja M. King

    IPC分类号： A61K39/395 ,  A61K38/18 ,  A61K9/22 ,  A61K31/56

    CPC分类号： A61K9/0024 ,  A61K31/56 ,  A61K38/18 ,  A61K38/1825 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1875 ,  A61K45/06 ,  Y10S514/801 ,  A61K2300/00

    摘要： A pump to deliver bone-growth factors to a carrier matrix within a patient. Pump can be internal or external. With external pumps, additional amounts of the same growth factor may be added, or the bioactive agent may be changed during the course of treatment. An external pump permits the use of cells to promote bone growth. The pump can have several reservoirs and the pump can itself be received in the carrier matrix with an outlet tube or other structure to defuse the growth factors into the carrier matrix. The pump protocol can be used for slow-to-heal fractures, such as closed fractures, and can be used for slow-to-heal patients.

    摘要翻译： 用于将骨生长因子递送到患者体内的载体基质的泵。 泵可以是内部或外部。 使用外部泵，可以添加额外量的相同生长因子，或者可以在治疗过程中改变生物活性剂。 外部泵允许使用细胞来促进骨骼生长。 泵可以具有多个储存器，并且泵本身可以使用出口管或其它结构容纳在载体矩阵中，以将生长因子消除到载体矩阵中。 泵方案可用于慢愈合骨折，如闭合性骨折，可用于慢愈合患者。

    Synergistic antimicrobial compositions containing 1-hydroxymethylpyrazole and a preservative
    10.
    发明授权
    Synergistic antimicrobial compositions containing 1-hydroxymethylpyrazole and a preservative 失效
    含有1-羟甲基吡唑和防腐剂的协同抗菌组合物

    公开(公告)号：US5859040A

    公开(公告)日：1999-01-12

    申请号：US863691

    申请日：1997-05-27

    申请人： Vanja M. King ,  Xiangdong Zhou

    发明人： Vanja M. King ,  Xiangdong Zhou

    IPC分类号： A01N35/02 ,  A01N35/08 ,  A01N37/40 ,  A01N43/50 ,  A01N43/56 ,  A01N43/64 ,  A01N43/80 ,  A01N43/90 ,  A01N47/36 ,  A01N33/18

    CPC分类号： A01N43/56

    摘要： Compositions comprising a compound of formula I ##STR1## where R and R' are independently selected from hydrogen and alkyl of 1 to 4 carbon atoms, R" is a moiety selected from the group consisting of (a) hydrogen, (b) a halogen atom selected from the group consisting of F, Cl, Br, and I, and (c) a nitro group, or the hydrochloride salt of said compound; and at least one preservative are disclosed which are synergistically effective compared to the respective components alone in controlling and/or reducing the growth of microorganisms in or on a material or medium. Methods to control and/or reduce the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.

    摘要翻译： 包含式I化合物的组合物，其中R和R'独立地选自氢和1-4个碳原子的烷基，R“是选自（a）氢，（b） 选自F，Cl，Br和I的卤素原子，和（c）硝基或所述化合物的盐酸盐; 并且公开了至少一种防腐剂，与单独的各组分相比，在控制和/或减少材料或介质中或其上的微生物的生长方面是协同有效的。 还公开了使用本发明组合物来控制和/或减少微生物生长并防止由微生物引起的变质的方法。