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    Integrin antagonists
    1.
    发明申请
    Integrin antagonists 审中-公开
    整合素拮抗剂

    公开(公告)号：US20060177443A1

    公开(公告)日：2006-08-10

    申请号：US11392436

    申请日：2006-03-28

    申请人： William Fanslow ,  Douglas Cerretti ,  Kurt Poindexter ,  Roy Black

    发明人： William Fanslow ,  Douglas Cerretti ,  Kurt Poindexter ,  Roy Black

    IPC分类号： A61K39/395 ,  A61K38/17

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/705

    摘要： The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration, and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said compositions. In preferred embodiments the methods and compositions of the invention are used to inhibit angiogenesis and to treat diseases or conditions mediated by angiogenesis.

    摘要翻译： 本发明提供抑制整联蛋白的生物学活性，抑制内皮细胞迁移和抑制血管发生的方法和组合物。 特别地，本发明提供包含ADAM去整合素结构域的组合物和使用所述组合物的方法。 在优选的实施方案中，本发明的方法和组合物用于抑制血管发生和治疗由血管发生介导的疾病或病症。

    Modal light-emitting device for mobile signal output devices methods and systems
    3.
    发明申请
    Modal light-emitting device for mobile signal output devices methods and systems 审中-公开
    用于移动信号输出装置的模态发光装置的方法和系统

    公开(公告)号：US20050280550A1

    公开(公告)日：2005-12-22

    申请号：US10947625

    申请日：2004-09-23

    申请人： Kerry Kurian ,  Roy Black

    发明人： Kerry Kurian ,  Roy Black

    IPC分类号： G09F9/33 ,  H05B37/02

    CPC分类号： H05B37/0245 ,  G09F9/33

    摘要： A method and device for illuminating a lighting element include an input for receiving an electrical signal from a separate mobile device, a lighting element, a memory for storing a plurality of user-selectable lighting modes, and a processor. The processor illuminates the lighting elements according to both the selected lighting mode and the electrical signal received from the separate device. The separate device may be a digital audio player, and the processor may vary the intensity of mode-specific lighting according to the signal from the audio player. Further, the selected mode may cause a strobe or text message to be displayed when another signal indicates that a page or email has been received. The lighting element may be an LED, an array of them, or a display screen with pixel lighting elements.

    摘要翻译： 用于照明照明元件的方法和设备包括用于从单独的移动设备接收电信号的输入，照明元件，用于存储多个用户可选照明模式的存储器和处理器。 处理器根据所选择的照明模式和从单独的装置接收的电信号照亮照明元件。 单独的设备可以是数字音频播放器，并且处理器可以根据来自音频播放器的信号改变模式特定照明的强度。 此外，当另一个信号指示已经接收到页面或电子邮件时，所选择的模式可能导致显示选通或文本消息。 照明元件可以是LED，它们的阵列，或具有像素照明元件的显示屏。

    Interleukin 1beta protease and interleukin 1beta protease inhibitors
    4.
    发明申请
    Interleukin 1beta protease and interleukin 1beta protease inhibitors 审中-公开
    白介素1beta蛋白酶和白细胞介素1β蛋白酶抑制剂

    公开(公告)号：US20060188474A1

    公开(公告)日：2006-08-24

    申请号：US11213530

    申请日：2005-08-25

    申请人： Paul Sleath ,  Roy Black ,  Shirley Kronheim

    发明人： Paul Sleath ,  Roy Black ,  Shirley Kronheim

    IPC分类号： A61K38/20 ,  C07K14/545 ,  C07H21/04 ,  C12P21/04

    CPC分类号： C12N9/6475 ,  A61K38/00 ,  C12N9/6421

    摘要： There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1β and for a substrate comprising: R1-Asp-R2-R3 wherein R1 and R3 are independently any D or L isomer amino acid, R2 is Ala or Gly, and wherein the specific protease cleavage site is between Asp and R2. Inhibitor compounds, compositions and methods for inhibiting Interleukin 1β protease activity are also disclosed. The inhibitor compounds comprise an amino acid sequence of from 1 to about 5 amino acids having an N-terminal blocking group and a C-terminal Asp residue connected to an electronegative leaving group, wherein the amino acid sequence corresponds to the sequence Ala-Tyr-Val-His-Asp.

    摘要翻译： 公开了一种分离的多肽及其衍生物，其对于人前体IL-1β和底物具有蛋白酶生物学活性，其包含：<？in-line-formula description =“In-line formula”end =“lead”？> R 1-in-line-formula description =“In-line Formulas”end =“tail”？> 其中R 1和R 3独立地是任何D或L异构体氨基酸，R 2是Ala或Gly，并且其中特异性蛋白酶裂解 位于Asp和R 2 2之间。 还公开了抑制白细胞介素1β蛋白酶活性的抑制剂化合物，组合物和方法。 抑制剂化合物包含具有N-末端封闭基团的1至约5个氨基酸的氨基酸序列和与电负离子基团连接的C末端Asp残基，其中氨基酸序列对应于序列Ala-Tyr- Val-His-Asp。