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公开(公告)号:US08008273B2
公开(公告)日:2011-08-30
申请号:US12819711
申请日:2010-06-21
IPC分类号: A61K48/00
CPC分类号: C12N9/16 , A01K67/0276 , A01K2217/075 , A01K2217/206 , A01K2227/105 , A01K2267/0387 , C12N15/1137 , C12N15/8509 , C12N2310/14 , C12N2310/531
摘要: The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.
摘要翻译: 本发明涉及通过抑制表达SHIP基因的巨核细胞或巨核细胞祖细胞中含SH2的肌醇-5-磷酸酶(SHIP)功能,在体外或体内增加巨核细胞和巨核细胞祖细胞数量的方法。 通过在体外或体内向巨核细胞或巨核细胞祖细胞施用干扰RNA或其他SHIP抑制剂可以抑制SHIP功能。
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2.
公开(公告)号:US20110064704A1
公开(公告)日:2011-03-17
申请号:US12883470
申请日:2010-09-16
IPC分类号: A61K35/12 , A61K31/7052 , C12N5/00 , A61P7/00
CPC分类号: C12N5/0644 , C12N2501/70
摘要: A method of increasing megakaryocytes and platelet numbers in a patient comprising the step of inhibiting SHIP expression, including SHIP's enzymatic activity and signaling functions, whereby normal blood clotting is induced.
摘要翻译: 一种增加患者的巨核细胞和血小板数的方法,包括抑制SHIP表达的步骤,包括SHIP的酶活性和信号功能,由此诱导正常的血液凝固。
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公开(公告)号:US20100260730A1
公开(公告)日:2010-10-14
申请号:US12819711
申请日:2010-06-21
CPC分类号: C12N9/16 , A01K67/0276 , A01K2217/075 , A01K2217/206 , A01K2227/105 , A01K2267/0387 , C12N15/1137 , C12N15/8509 , C12N2310/14 , C12N2310/531
摘要: The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.
摘要翻译: 本发明涉及通过抑制表达SHIP基因的巨核细胞或巨核细胞祖细胞中含SH2的肌醇-5-磷酸酶(SHIP)功能,在体外或体内增加巨核细胞和巨核细胞祖细胞数量的方法。 通过在体外或体内向巨核细胞或巨核细胞祖细胞施用干扰RNA或其他SHIP抑制剂可以抑制SHIP功能。
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公开(公告)号:US07807646B1
公开(公告)日:2010-10-05
申请号:US10904667
申请日:2004-11-22
IPC分类号: A61K48/00
CPC分类号: C12N5/0644 , C12N2501/70
摘要: A method of increasing megakaryocytes and platelet numbers in a patient comprising the step of inhibiting SHIP expression, including SHIP's enzymatic activity and signaling functions, whereby normal blood clotting is induced.
摘要翻译: 一种增加患者的巨核细胞和血小板数的方法,包括抑制SHIP表达的步骤,包括SHIP的酶活性和信号功能,由此诱导正常的血液凝固。
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公开(公告)号:US07763592B1
公开(公告)日:2010-07-27
申请号:US11451004
申请日:2006-06-12
IPC分类号: A61K48/00
CPC分类号: C12N9/16 , A01K67/0276 , A01K2217/075 , A01K2217/206 , A01K2227/105 , A01K2267/0387 , C12N15/1137 , C12N15/8509 , C12N2310/14 , C12N2310/531
摘要: The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.
摘要翻译: 本发明涉及通过抑制表达SHIP基因的巨核细胞或巨核细胞祖细胞中含SH2的肌醇-5-磷酸酶(SHIP)功能,在体外或体内增加巨核细胞和巨核细胞祖细胞数量的方法。 通过在体外或体内向巨核细胞或巨核细胞祖细胞施用干扰RNA或其他SHIP抑制剂可以抑制SHIP功能。
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