公开(公告)号：US07203535B1

公开(公告)日：2007-04-10

申请号：US09417558

申请日：1999-10-13

申请人： William Hsu ,  Robert J. Sweeney ,  Eric G. Lovett

发明人： William Hsu ,  Robert J. Sweeney ,  Eric G. Lovett

IPC分类号： A61B5/0402

CPC分类号： A61N1/3622 ,  A61N1/3962

摘要： An implantable cardioverter/defibrillator includes a tachycardia detection system that detects one-to-one (1:1) tachycardia, which is a tachycardia with a one-to-one relationship between atrial and ventricular contractions. When the 1:1 tachycardia is detected, the system discriminates ventricular tachycardia (VT) from supraventricular tachycardia (SVT) based on analysis of a cardiac time interval. Examples of the cardiac time interval include an atrioventricular interval (AVI) and a ventriculoatrial interval (VAI). A template time interval is created during a known normal sinus rhythm. The system measures a tachycardia time interval after detecting the 1:1 tachycardia, and indicates a VT detection if the tachycardia time interval differs from the template time interval by at least a predetermined percentage of the template time interval.

摘要翻译： 用于区分沿逆行方向发生的心律的顺行方向发生的心律的系统和方法。 感觉心房去极化和心室去极化。 当检测到心房去极化与心脏去极化具有一对一关联的心动过速发作时，测量心室去极化与第一预定心脏事件之间的第一间隔以及心房去极化和第二预定心脏事件之间的第二间隔。 然后将第一和第二间隔的特征用于将心动过速发作分类为顺行节律或逆行节律。

公开(公告)号：US06456871B1

公开(公告)日：2002-09-24

申请号：US09452670

申请日：1999-12-01

申请人： William Hsu ,  Robert J. Sweeney ,  Eric G. Lovett

发明人： William Hsu ,  Robert J. Sweeney ,  Eric G. Lovett

IPC分类号： A61B50464

CPC分类号： A61N1/3702 ,  A61N1/3622

摘要： A method and system for classifying tachyarrhythmia episodes as associated or disassociated. Primary and auxiliary depolarizations are detected from different cardiac regions during a tachycardia episode. A first time interval is positioned to surround each of one or more primary depolarizations, including auxiliary depolarizations that occur in the first time interval. The auxiliary depolarizations occurring in the first time interval are then counted. Based on the number and the location of the auxiliary depolarizations counted in the first time intervals, the one or more primary depolarizations and the auxiliary depolarizations of the tachycardia episode are classified as disassociated or associated.

摘要翻译： 一种将快速性心律失常发作分类为相关或不相关的方法和系统。 在心动过速发作期间，从不同的心脏区域检测到初级和辅助去极化。 第一时间间隔定位成围绕一个或多个主去极化中的每一个，包括在第一时间间隔中发生的辅助去极化。 然后计算在第一时间间隔内发生的辅助去极化。 根据在第一次间隔中计数的辅助去极化的数量和位置，心动过速发作的一次或多次初次去极化和辅助去极化被分类为分离或相关联。

公开(公告)号：US07151958B2

公开(公告)日：2006-12-19

申请号：US10211222

申请日：2002-08-02

申请人： William Hsu ,  Robert J. Sweeney ,  Eric G. Lovett

发明人： William Hsu ,  Robert J. Sweeney ,  Eric G. Lovett

IPC分类号： A61B5/046

CPC分类号： A61N1/3702 ,  A61N1/3622

摘要： A method and system for classifying tachyarrhythmia episodes as associated or disassociated. Primary and auxiliary depolarizations are detected from different cardiac regions during a tachycardia episode. A first time interval is positioned to surround each of one or more primary depolarizations, including auxiliary depolarizations that occur in the first time interval. The auxiliary depolarizations occurring in the first time interval are then counted. Based on the number and the location of the auxiliary depolarizations counted in the first time intervals, the one or more primary depolarizations and the auxiliary depolarizations of the tachycardia episode are classified as disassociated or associated.

公开(公告)号：US07062316B2

公开(公告)日：2006-06-13

申请号：US10347725

申请日：2003-01-21

申请人： William Hsu ,  Robert J. Sweeney

发明人： William Hsu ,  Robert J. Sweeney

IPC分类号： A61B5/0402

CPC分类号： A61N1/3622

摘要： A system and method for discriminating cardiac rhythms occurring in an antegrade direction from cardiac rhythms occurring in a retrograde direction. Atrial and ventricular contractions are sensed, from which atrial and ventricular cycle lengths are determined. Ventricular contractions are also analyzed to determine the occurrence of a tachycardia episode that has a one-to-one association of atrial contractions to ventricular contractions. During a tachycardia episode having a one-to-one association of atrial contractions to ventricular contractions, the atrial cycle lengths are paired with the ventricular cycle lengths, where for each of the atrial cycle lengths the atrial cycle length is paired with at least one ventricular cycle length started before the first atrial contraction of each of the atrial cycle lengths and paired with at least one ventricular cycle length started after the first atrial contraction of each of the atrial cycle lengths. A retrograde correlation coefficient is then determined for the atrial cycle lengths paired with the ventricular cycle lengths started before the first atrial contraction, and an antegrade correlation coefficient is determined for the atrial cycle lengths paired with the ventricular cycle lengths started after the first atrial contraction. The tachycardiac episode is then classified based on a comparison of the antegrade correlation coefficient and the retrograde correlation coefficient.

公开(公告)号：US06179865B2

公开(公告)日：2001-01-30

申请号：US09283159

申请日：1999-04-01

申请人： William Hsu ,  Robert J. Sweeney

发明人： William Hsu ,  Robert J. Sweeney

IPC分类号： A61B50464

CPC分类号： A61N1/3622

摘要： A system and method for discriminating cardiac rhythms occurring in an antegrade direction from cardiac rhythms occurring in a retrograde direction. Atrial and ventricular contractions are sensed, from which atrial and ventricular cycle lengths are determined. Ventricular contractions are also analyzed to determine the occurrence of a tachycardia episode that has a one-to-one association of atrial contractions to ventricular contractions. During a tachycardia episode having a one-to-one association of atrial contractions to ventricular contractions, the atrial cycle lengths are paired with the ventricular cycle lengths, where for each of the atrial cycle lengths the atrial cycle length is paired with at least one ventricular cycle length started before the first atrial contraction of each of the atrial cycle lengths and paired with at least one ventricular cycle length started after the first atrial contraction of each of the atrial cycle lengths. A retrograde correlation coefficient is then determined for the atrial cycle lengths paired with the ventricular cycle lengths started before the first atrial contraction, and an antegrade correlation coefficient is determined for the atrial cycle lengths paired with the ventricular cycle lengths started after the first atrial contraction. The tachycardiac episode is then classified based on a comparison of the antegrade correlation coefficient and the retrograde correlation coefficient.

摘要翻译： 用于区分沿逆行方向发生的心律的顺行方向发生的心律的系统和方法。 感测到心房和心室收缩，确定心房和心室周期长度。 还分析心室收缩以确定心房收缩与心室收缩具有一对一关联的心动过速发作的发生。 在心房收缩与心室收缩有一对一关联的心动过速发作期间，心房周期长度与心室周期长度配对，其中对于心房周期长度中的每一个，心房周期长度与至少一个心室 循环长度在每个心房周期长度的第一次心房收缩之前开始，并且与每个心房周期长度的第一次心房收缩之后开始的至少一个心室周期长度配对。 然后确定与在第一次心房收缩之前开始的心室周期长度成对的心房周期长度的逆行相关系数，并且确定与在第一次心房收缩之后开始的心室周期长度配对的心房周期长度的顺行相关系数。 然后根据顺行相关系数与逆行相关系数的比较对心动过速进行分类。

公开(公告)号：US06526313B2

公开(公告)日：2003-02-25

申请号：US09874892

申请日：2001-06-05

申请人： Robert J. Sweeney ,  William Hsu

发明人： Robert J. Sweeney ,  William Hsu

IPC分类号： A61B50402

CPC分类号： A61B5/7264 ,  A61B5/042 ,  A61B5/04525 ,  A61N1/3962

摘要： A system and method for classifying cardiac depolarization complexes in which waveforms of a depolarization complex are sensed by separate electrodes and correlated with template waveforms of a template depolarization complex. The system is particularly suitable for incorporation into a cardiac rhythm management device such as an implantable cardioverter/defibrillator or pacemaker in order to facilitate arrhythmia prediction and/or prevention.

公开(公告)号：US07610084B2

公开(公告)日：2009-10-27

申请号：US11422772

申请日：2006-06-07

申请人： Robert J. Sweeney ,  William Hsu

发明人： Robert J. Sweeney ,  William Hsu

IPC分类号： A61B5/402

CPC分类号： A61B5/7264 ,  A61B5/042 ,  A61B5/04525 ,  A61N1/3962

摘要： A system and method for classifying cardiac depolarization complexes in which waveforms of a depolarization complex are sensed by separate electrodes and correlated with template waveforms of a template depolarization complex. The system is particularly suitable for incorporation into a cardiac rhythm management device such as an implantable cardioverter/defibrillator or pacemaker in order to facilitate arrhythmia prediction and/or prevention.

摘要翻译： 用于分类心脏去极化复合物的系统和方法，其中去极化复合物的波形由单独的电极感测并与模板去极化复合体的模板波形相关联。 该系统特别适合于并入心脏节律管理装置，例如可植入的心律转复器/除颤器或起搏器，以便于预防和/或预防心律失常。

公开(公告)号：US06522917B1

公开(公告)日：2003-02-18

申请号：US09615014

申请日：2000-07-12

申请人： William Hsu ,  Robert J. Sweeney

发明人： William Hsu ,  Robert J. Sweeney

IPC分类号： A61B50464

CPC分类号： A61N1/3622

摘要： A system and method for discriminating cardiac rhythms occurring in an antegrade direction from cardiac rhythms occurring in a retrograde direction. Atrial and ventricular contractions are sensed, from which atrial and ventricular cycle lengths are determined. Ventricular contractions are also analyzed to determine the occurrence of a tachycardia episode that has a one-to-one association of atrial contractions to ventricular contractions. During a tachycardia episode having a one-to-one association of atrial contractions to ventricular contractions, the atrial cycle lengths are paired with the ventricular cycle lengths, where for each of the atrial cycle lengths the atrial cycle length is paired with at least one ventricular cycle length started before the first atrial contraction of each of the atrial cycle lengths and paired with at least one ventricular cycle length started after the first atrial contraction of each of the atrial cycle lengths. A retrograde correlation coefficient is then determined for the atrial cycle lengths paired with the ventricular cycle lengths started before the first atrial contraction, and an antegrade correlation coefficient is determined for the atrial cycle lengths paired with the ventricular cycle lengths started after the first atrial contraction. The tachycardiac episode is then classified based on a comparison of the antegrade correlation coefficient and the retrograde correlation coefficient.

公开(公告)号：US08214027B2

公开(公告)日：2012-07-03

申请号：US12080891

申请日：2008-04-07

申请人： Jaeho Kim ,  William Hsu ,  Joseph Bocek ,  Harley White

发明人： Jaeho Kim ,  William Hsu ,  Joseph Bocek ,  Harley White

IPC分类号： A61B5/0464

CPC分类号： A61B5/04525

摘要： A method and system provides for generating a snapshot representative of one beat of a patient's normal cardiac rhythm. Cardiac rate channel signals and shock channel signals are sensed. A fiducial point is determined for a predefined number of the cardiac rate channel signals. A predefined number of the shock channel signals are aligned using the fiducial point. A template is generated using the aligned shock channel signals, whereby the template is representative of one of the patient's normal supra-ventricular conducted cardiac beats. The template is updated on a periodic basis.

摘要翻译： 一种方法和系统提供用于产生代表患者正常心律的一次搏动的快照。 检测心率通道信号和冲击通道信号。 为预定数量的心率通道信号确定基准点。 使用基准点对预定数量的冲击通道信号进行对准。 使用对准的冲击通道信号产生模板，由此模板代表患者的正常心室心脏传出心跳中的一个。 模板定期更新。

公开(公告)号：US20120165884A1

公开(公告)日：2012-06-28

申请号：US12975794

申请日：2010-12-22

申请人： Cecilia Qin Xi ,  Stuart Rosenberg ,  Jong Gill ,  Yelena Nabutovsky ,  William Hsu ,  Brian Jeffrey Wenzel

发明人： Cecilia Qin Xi ,  Stuart Rosenberg ,  Jong Gill ,  Yelena Nabutovsky ,  William Hsu ,  Brian Jeffrey Wenzel

IPC分类号： A61B5/053 ,  A61N1/39 ,  A61N1/362

CPC分类号： A61B5/0538 ,  A61B5/0537 ,  A61B5/4878 ,  A61B5/7239 ,  A61N1/3627 ,  A61N1/36521

摘要： Provided herein are implantable systems, and methods for use therewith, for monitoring a patient's fluid accumulation level. A thoracic impedance signal for the patient is obtained. Based on the thoracic impedance signal, a duration metric indicative of a duration of drop of the thoracic impedance signal, a magnitude metric indicative of a magnitude of drop of the thoracic impedance signal, and a rate metric indicative of a rate of drop of the thoracic impedance signal is determined. The patient's fluid accumulation level is monitored based on the duration metric, the magnitude metric and the rate metric.

摘要翻译： 本文提供了可植入系统及其使用的方法，用于监测患者的血液积聚水平。 获得患者的胸部阻抗信号。 基于胸部阻抗信号，指示胸部阻抗信号下降持续时间的持续时间度量，指示胸部阻抗信号的下降幅度的幅度度量，以及指示胸部下降速率的速率度量 确定阻抗信号。 基于持续时间度量，幅度度量和速率度量来监测患者的血液积聚水平。