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公开(公告)号:US08569350B2
公开(公告)日:2013-10-29
申请号:US13403617
申请日:2012-02-23
申请人: William J. Welsh , Youyi Peng , Xin Wang , Susan M. Keenan , Qiang Zhang , Sonia Arora
发明人: William J. Welsh , Youyi Peng , Xin Wang , Susan M. Keenan , Qiang Zhang , Sonia Arora
IPC分类号: A61K31/4196 , C07D249/08
CPC分类号: C07D249/08 , C07D403/04
摘要: Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.
摘要翻译: 提出了取代的三唑化合物及其药物组合物。 还提出了通过向有需要的患者施用取代的三唑化合物来治疗与过度增殖性病症相关的病理学的方法。
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公开(公告)号:US20090317440A1
公开(公告)日:2009-12-24
申请号:US11577953
申请日:2005-10-25
申请人: William J. Welsh , Youyi Peng , Xin Wang , Susan M. Keenan , Qiang Zhang , Sonia Arora
发明人: William J. Welsh , Youyi Peng , Xin Wang , Susan M. Keenan , Qiang Zhang , Sonia Arora
IPC分类号: A61K9/00 , C07D249/08 , A61K31/4196 , A61P35/00 , A61P29/00
CPC分类号: C07D249/08 , C07D403/04
摘要: Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.
摘要翻译: 提出了取代的三唑化合物及其药物组合物。 还提出了通过向有需要的患者施用取代的三唑化合物来治疗与过度增殖性病症相关的病理学的方法。
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公开(公告)号:US08188128B2
公开(公告)日:2012-05-29
申请号:US11914231
申请日:2006-05-12
申请人: William J. Welsh , Youyi Peng , Qiang Zhang , Susan M. Keenan , Sonia Arora
发明人: William J. Welsh , Youyi Peng , Qiang Zhang , Susan M. Keenan , Sonia Arora
IPC分类号: A61K31/4196 , C07D249/08
CPC分类号: C07D249/08
摘要: Opioid receptor compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a condition mediated by an opioid receptor by administering an effective amount of the opioid receptor compound to a patient in need thereof.
摘要翻译: 提出阿片受体化合物及其药物组合物。 还提出了通过向有需要的患者施用有效量的阿片受体化合物来治疗由阿片受体介导的病症的方法。
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公开(公告)号:US20120149744A1
公开(公告)日:2012-06-14
申请号:US13403617
申请日:2012-02-23
申请人: William J. Welsh , Youyi Peng , Xin Wang , Susan M. Keenan , Qiang Zhang , Sonia Arora
发明人: William J. Welsh , Youyi Peng , Xin Wang , Susan M. Keenan , Qiang Zhang , Sonia Arora
IPC分类号: A61K31/4196 , A61P35/02 , A61P35/00
CPC分类号: C07D249/08 , C07D403/04
摘要: Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.
摘要翻译: 提出了取代的三唑化合物及其药物组合物。 还提出了通过向有需要的患者施用取代的三唑化合物来治疗与过度增殖性病症相关的病理学的方法。
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公开(公告)号:US08143299B2
公开(公告)日:2012-03-27
申请号:US11577953
申请日:2005-10-25
申请人: William J. Welsh , Youyi Peng , Xin Wang , Susan M. Keenan , Qiang Zhang , Sonia Arora
发明人: William J. Welsh , Youyi Peng , Xin Wang , Susan M. Keenan , Qiang Zhang , Sonia Arora
IPC分类号: A61K31/4196 , C07D249/08
CPC分类号: C07D249/08 , C07D403/04
摘要: Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.
摘要翻译: 呈现了取代的三唑化合物及其药物组合物。 还提出了通过向有需要的患者施用取代的三唑化合物来治疗与过度增殖性病症相关的病理学的方法。
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公开(公告)号:US20090181998A1
公开(公告)日:2009-07-16
申请号:US11914231
申请日:2006-05-12
申请人: William J. Welsh , Youyi Peng , Qiang Zhang , Susan M. Keenan , Sonia Arora
发明人: William J. Welsh , Youyi Peng , Qiang Zhang , Susan M. Keenan , Sonia Arora
IPC分类号: A61K31/485 , C07D249/08 , A61K31/4196 , A61K31/445
CPC分类号: C07D249/08
摘要: Opioid receptor compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a condition mediated by an opioid receptor by administering an effective amount of the opioid receptor compound to a patient in need thereof.
摘要翻译: 提出阿片受体化合物及其药物组合物。 还提出了通过向有需要的患者施用有效量的阿片受体化合物来治疗由阿片受体介导的病症的方法。
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公开(公告)号:US20190127361A1
公开(公告)日:2019-05-02
申请号:US16311136
申请日:2017-06-16
申请人: William J. WELSH , Raymond BIRGE , Vladyslav KHOLODOVYCH , Youyi PENG , Thomas Walter COMOLLO , Stanley G. KIMANI , Rutgers, The State University of New Jersey , The Curators of the University of Missouri
发明人: William J. Welsh , Raymond Birge , Vladyslav Kholodovych , Youyi Peng , Thomas Walter Comollo , Stanley G. Kimani , Kamlendra Singh
IPC分类号: C07D417/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D409/14 , C07D261/08 , A61P35/00 , A61P31/18 , A61P7/02 , A61P9/00
摘要: Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.
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公开(公告)号:US09469625B2
公开(公告)日:2016-10-18
申请号:US14128378
申请日:2012-06-22
申请人: Peng Li , Youyi Peng , John Tomesch , Lawrence P. Wennogle , Qiang Zhang
发明人: Peng Li , Youyi Peng , John Tomesch , Lawrence P. Wennogle , Qiang Zhang
IPC分类号: A61K31/445 , C07D401/12 , A61K31/454 , A61K31/4745 , A61K31/506 , A61K33/24 , A61K45/06
CPC分类号: C07D401/12 , A61K31/41 , A61K31/415 , A61K31/454 , A61K31/4745 , A61K31/506 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要: The invention relates to compounds and methods of treatment relating to nicotinic receptor antagonists. For example, the compounds and methods of treatment function block the activity of certain acetylcholine receptors and subtypes therein, and are useful treating diseases and conditions mediated by nicotinic receptor stimulation, e.g., small cell lung cancer.
摘要翻译: 本发明涉及与烟碱受体拮抗剂有关的化合物和治疗方法。 例如,化合物和治疗方法功能阻断其中某些乙酰胆碱受体和亚型的活性,并且可用于治疗由烟碱样受体刺激(例如小细胞肺癌)介导的疾病和病症。
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9.
公开(公告)号:US09452160B2
公开(公告)日:2016-09-27
申请号:US14742570
申请日:2015-06-17
申请人: Youyi Peng , Lawrence P. Wennogle , Qiang Zhang , John Tomesch
发明人: Youyi Peng , Lawrence P. Wennogle , Qiang Zhang , John Tomesch
IPC分类号: A61K31/445 , A61K31/454 , A61K31/4745 , A61K31/506 , A61K33/24 , A61K45/06 , C07D401/12 , A61K31/41 , A61K31/415 , A61K31/7068
CPC分类号: C07D401/12 , A61K31/41 , A61K31/415 , A61K31/454 , A61K31/4745 , A61K31/506 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要: It is an object of the present invention that the novel nicotinic receptor antagonists disclosed herein may be used in a broad array of clinical or medicinal facets. For example, it is a contemplated use of the present invention that the novel nicotinic receptor antagonists be used to inhibit the growth cycle of non-small cell lung cancer cells. Without being bound by theory, it is an object of the present invention that the nicotinic receptor antagonists disclosed herein are believed to possess reversible binding properties. Moreover, the compounds of the present invention are selective for 0.7 nAChR. For example, the compounds of the present invention are not believed to bind to 0.4 (32 nAChR neuromuscular receptors. It is also contemplated that the nicotinic receptor antagonists of the present invention will be used as a counter measure to treat exposure, or potential exposure, to a wide array of potential neurotoxins.
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公开(公告)号:US20140205596A1
公开(公告)日:2014-07-24
申请号:US14128378
申请日:2012-06-22
申请人: Peng Li , Youyi Peng , John Tomesch , Lawrence P. Wennogle , Qiang Zhang
发明人: Peng Li , Youyi Peng , John Tomesch , Lawrence P. Wennogle , Qiang Zhang
IPC分类号: C07D401/12 , A61K45/06 , A61K31/454
CPC分类号: C07D401/12 , A61K31/41 , A61K31/415 , A61K31/454 , A61K31/4745 , A61K31/506 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K2300/00
摘要: The invention relates to compounds and methods of treatment relating to nicotinic receptor antagonists. For example, the compounds and methods of treatment function block the activity of certain acetylcholine receptors and subtypes therein, and are useful treating diseases and conditions mediated by nicotinic receptor stimulation, e.g., small cell lung cancer.
摘要翻译: 本发明涉及与烟碱受体拮抗剂有关的化合物和治疗方法。 例如,化合物和治疗方法功能阻断某些乙酰胆碱受体及其亚型的活性,并且可用于治疗由烟碱受体刺激例如小细胞肺癌介导的疾病和病症。
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