公开(公告)号：US20220313599A1

公开(公告)日：2022-10-06

申请号：US17633716

申请日：2020-08-07

Applicant: William Marsh Rice University

Inventor： Omid VEISEH ,  Amanda NASH ,  Maria Isabel JARVIS-RUOCCO ,  Sudip MUKHERJEE ,  Michael David DOERFERT ,  Samira AGHLARA-FOTOVAT ,  David Yu ZHANG

IPC: A61K9/00 ,  A61K45/06

Abstract: The present disclosure relates to implantable constructs designed to deliver antigenic therapeutic reagents to a subject while providing protection from host immune responses. In certain aspects, the constructs are designed to degrade over time or upon a particular signal, thereby providing control of the length of time the therapeutic agent is delivered to the subject.

公开(公告)号：US20240301093A1

公开(公告)日：2024-09-12

申请号：US18569673

申请日：2022-06-14

Applicant: William Marsh Rice University

Inventor： David ZHANG ,  Ping SONG ,  Omid VEISEH ,  Siavash PARKHIDEH ,  Sudip MUKHERJEE ,  Maria Isabel RUOCCO ,  Boram KIM ,  Michael David DOERFERT ,  Yuxuan CHENG

IPC: C08B37/00 ,  A61K9/48 ,  A61K35/39 ,  A61K35/51 ,  A61L27/34 ,  A61L27/38 ,  A61L29/08 ,  C12Q1/6881

CPC classification number: C08B37/0084 ,  A61K9/4816 ,  A61K35/39 ,  A61K35/51 ,  A61L27/34 ,  A61L27/3804 ,  A61L29/085 ,  C12Q1/6881 ,  A61L2400/02

Abstract: Disclosed herein are compounds of the formula: A-L-R1(I), wherein the these variables are defined herein, as well as medical devices comprising said compounds. The present disclosure also provides pharmaceutical compositions comprising the compounds or medical devices disclosed herein. Further, the present disclosure provides methods of treatment using the compounds, medical devices, or pharmaceutical compositions disclosed herein.